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Evaluation of Possible Consequences of Zika Virus Infection in the Developing Nervous System

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Abstract

The Zika virus (ZIKV) outbreak that occurred in the northeast of Brazil in 2015 led to alarming numbers of babies born with microcephaly in this region. Since then, several studies have evaluated the relationship between ZIKV infection and development of the malformation although the specific mechanistic interaction between ZIKV and human physiological processes that ultimately manifest as microcephaly remains debated. Importantly, most current studies did not consider the specificities of the biology and life cycle of ZIKV. As a consequence, specificities of the infection on the developing central nervous system (CNS) were frequently disregarded. In order to begin to address this important gap in our knowledge, we have collated and critically reviewed the existing evidence in this area to identify any emerging consensus on this topic and thereafter describe possible mechanisms by which ZIKV infection could interfere with specific processes of CNS development, such as neuronal proliferation, and the complex interactions of immature neurons with radial glial cells. With this, we were able to present the current knowledge on this important topic in the neurobiology field.

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Acknowledgements

AHK is grateful for grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (2014/16711-6) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (308608/2014-3).

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Authors and Affiliations

  1. Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil

    Lais Takata Walter, Guilherme Shigueto Vilar Higa, Juliane Midori Ikebara, Silvia Honda Takada, Erika Reime Kinjo & Alexandre Hiroaki Kihara

  2. Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil

    Guilherme Shigueto Vilar Higa & Alexandre Hiroaki Kihara

  3. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil

    Danila Vedovello & Márcia Aparecida Sperança

  4. Laboratório de Virologia, Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, SP, Brazil

    Felipe Scassi Salvador

  5. School of Chemistry, Food and Nutritional Sciences, and Pharmacy, University of Reading, Whiteknights, Berkshire, Reading, UK

    Benjamin J. Whalley

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  1. Lais Takata Walter
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Walter, L.T., Higa, G.S.V., Ikebara, J.M. et al. Evaluation of Possible Consequences of Zika Virus Infection in the Developing Nervous System. Mol Neurobiol 55, 1620–1629 (2018). https://doi.org/10.1007/s12035-017-0442-5

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