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T2- and T1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes

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Abstract

The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM−1 s−1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.

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Multifunctional nanoparticles for dual-mode MRI contrast and hyperthermia.

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Acknowledgement

The work was funded by the Government assignment for FRC Kazan Scientific Center of Russian academy of Science (Reg. Nr. AAAA-A18-118041760011-2). M.R. thanks National Science Foundation of China (Grant No. 52071225) and the Czech Republic under the ERDF program “Institute of Environmental Technology—Excellent Research” (No. CZ.02.1.01/0.0/0.0/16_019/0000853).

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Authors and Affiliations

  1. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan, Russia, 420088

    ALEXEY STEPANOV, SVETLANA FEDORENKO, KIRILL KHOLIN, ALEXANDRA VOLOSHINA, ANASTASIYA SAPUNOVA, SVETLANA SOLOVIEVA & ASIYA MUSTAFINA

  2. Leibniz Institute for Solid State and Materials Research Dresden, P.O. Box 270116, 01171 , Dresden, Germany

    RAFAEL MENDES, MARK RÜMMELI, LARS GIEBELER, BRUNO WEISE & THOMAS GEMMING

  3. Soochow Institute for Energy and Materials Innovations, College of Energy, Collaborative Innovation Center of Suzhou Nano Science and Technology, Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou, 215006, China

    MARK RÜMMELI

  4. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819, Zabrze, Poland

    MARK RÜMMELI

  5. Institute of Environmental Technology, VŠB-Technical University of Ostrava, 17 Listopadu 15, 708 33, Ostrava, Czech Republic

    MARK RÜMMELI

  6. Institute of Biomedical Engineering and Informatics (BMTI), Technische Universität Ilmenau, Ilmenau, Germany

    SILVIO DUTZ & DIANA ZAHN

  7. A.N. Tupolev Kazan Research Technological University, Kazan, Russia, 420015

    ILDUS ISMAEV

  8. Kazan (Volga Region) Federal University, Kremlyovskaya Str., 18, Kazan, Russia, 420008

    RUSTEM AMIROV

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  1. ALEXEY STEPANOV
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Correspondence to ALEXEY STEPANOV.

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STEPANOV, A., FEDORENKO, S., MENDES, R. et al. T2- and T1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes. J Chem Sci 133, 43 (2021). https://doi.org/10.1007/s12039-021-01904-7

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