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Synthesis of Bioresorbable Poly(Lactic-co-Glycolic Acid)s Through Direct Polycondensation: An Economical Substitute for the Synthesis of Polyglactin via ROP of Lactide and Glycolide

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Abstract

High molecular weight bioresorbable polyglactin was successfully synthesized by direct esterification of glycolic acid and lactic acid in diphenylether under vacuum. The reaction mixture was initially dehydrated at 120 °C, diphenylether and catalysts were added when the temperature was raised to 180 °C, meanwhile the reaction mixture was kept dehydrated azeotropically for several hours. Diphenylether was removed from reaction mixture using vacuum and white solid polyglactin was obtained after purification. The intrinsic viscosity of polyglactin was in a range of 0.6 to 1.10 dl/g. This synthesis process can be an economical alternative to the conventional synthesis of polyglactin.

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Authors and Affiliations

  1. Department of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea

    Muhammad Ayyoob, Xin Yang, Soo-young Park, Ji Heung Kim, Sung Woo Nam & Young Jun Kim

  2. Department of Polymer Science, Kyungpook National University, Daegu, 41566, Korea

    Ho-Joon Park

Authors
  1. Muhammad Ayyoob
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  2. Xin Yang
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  3. Ho-Joon Park
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  4. Soo-young Park
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  5. Ji Heung Kim
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  6. Sung Woo Nam
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  7. Young Jun Kim
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Correspondence to Young Jun Kim.

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Ayyoob, M., Yang, X., Park, HJ. et al. Synthesis of Bioresorbable Poly(Lactic-co-Glycolic Acid)s Through Direct Polycondensation: An Economical Substitute for the Synthesis of Polyglactin via ROP of Lactide and Glycolide. Fibers Polym 20, 887–895 (2019). https://doi.org/10.1007/s12221-019-1143-7

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  • DOI: https://doi.org/10.1007/s12221-019-1143-7

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