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The Role of Host Cytoskeleton in Flavivirus Infection

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Virologica Sinica

Abstract

The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses. Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry, intracellular transport, replication, and egress process, although many detailed mechanisms are still unclear. This article provides a brief overview of the function of the most prominent flaviviruses-induced or -hijacked cytoskeletal structures including actin, microtubules and intermediate filaments, mainly focus on infection by dengue virus, Zika virus and West Nile virus. We suggest that virus interaction with host cytoskeleton to be an interesting area of future research.

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Acknowledgements

We thank Xia Jin (Institut Pasteur of Shanghai, Chinese Academy of Science) for discussions and critical reading of the manuscript. This work was supported by Collaborative Research Grant (KLMVI-OP-201904) of CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, and the starting Grant of Institut Pasteur of Shanghai (1185170000), Chinese Academy of Sciences.

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  1. CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China

    Yue Zhang, Wei Gao, Jian Li, Weihua Wu & Yaming Jiu

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yue Zhang, Wei Gao & Yaming Jiu

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  1. Yue Zhang
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  2. Wei Gao
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  3. Jian Li
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Zhang, Y., Gao, W., Li, J. et al. The Role of Host Cytoskeleton in Flavivirus Infection. Virol. Sin. 34, 30–41 (2019). https://doi.org/10.1007/s12250-019-00086-4

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