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Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration?

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References

  1. Sun BL, Li WW, Zhu C, Jin WS, Zeng F, Liu YH, et al. Clinical research on Alzheimer’s disease: Progress and perspectives. Neurosci Bull 2018, 34: 1111–1118.

    Article  CAS  Google Scholar 

  2. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012, 4: 147ra111.

  3. Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 2015, 212: 991–999.

    Article  CAS  Google Scholar 

  4. Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. Structural and functional features of central nervous system lymphatic vessels. Nature 2015, 523: 337–341.

    Article  CAS  Google Scholar 

  5. Ahn JH, Cho H, Kim JH, Kim SH, Ham JS, Park I, et al. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature 2019, 572: 62–66.

    Article  CAS  Google Scholar 

  6. Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, et al. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease. Acta Neuropathol 2015, 130: 487–499.

    Article  CAS  Google Scholar 

  7. Wang J, Jin WS, Bu XL, Zeng F, Huang ZL, Li WW, et al. Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies. Acta Neuropathol 2018, 136: 525–536.

    Article  CAS  Google Scholar 

  8. Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature 2018, 560: 185–191.

    Article  CAS  Google Scholar 

  9. Wang J, Gu BJ, Masters CL, Wang YJ. A systemic view of Alzheimer disease—insights from amyloid-beta metabolism beyond the brain. Nat Rev Neurol 2017, 13: 612–623.

    Article  CAS  Google Scholar 

  10. Bu XL, Xiang Y, Jin WS, Wang J, Shen LL, Huang ZL, et al. Blood-derived amyloid-beta protein induces Alzheimer’s disease pathologies. Mol Psychiatry 2018, 23: 1948–1956.

    Article  CAS  Google Scholar 

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Acknowledgements

This highlight was supported by the National Natural Science Foundation of China (91749206).

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Correspondence to Yan-Jiang Wang.

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Cheng, Y., Wang, YJ. Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration?. Neurosci. Bull. 36, 557–560 (2020). https://doi.org/10.1007/s12264-019-00456-8

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  • DOI: https://doi.org/10.1007/s12264-019-00456-8

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