References
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402: 656–660.
Mandal A, Prabhavalkar KS, Bhatt LK. Gastrointestinal hormones in regulation of memory. Peptides 2018, 102: 16–25.
Jiao Q, Du X, Li Y, Gong B, Shi L, Tang T, et al. The neurological effects of ghrelin in brain diseases: beyond metabolic functions. Neurosci Biobehav Rev 2017, 73: 98–111.
Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, et al. Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci 2009, 29: 14057–14065.
Shi L, Bian X, Qu Z, Ma Z, Zhou Y, Wang K, et al. Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels. Nat Commun 2013, 4: 1435.
Liu C, Xue Y, Liu MF, Wang Y, Liu ZR, Diao HL, et al. Orexins increase the firing activity of nigral dopaminergic neurons and participate in motor control in rats. J Neurochem 2018, 147: 380–394.
Dragicevic E, Schiemann J, Liss B. Dopamine midbrain neurons in health and Parkinson’s disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience 2015, 284: 798–814.
Chen X, Xue B, Wang J, Liu H, Shi L, Xie J. Potassium channels: a potential therapeutic target for Parkinson’s disease. Neurosci Bull 2018, 34: 341–348.
Liss B, Franz O, Sewing S, Bruns R, Neuhoff H, Roeper J. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. EMBO J 2001, 20: 5715–5724.
Haghdoost-Yazdi H, Piri H, Najafipour R, Faraji A, Fraidouni N, Dargahi T, et al. Blockade of fast A-type and TEA-sensitive potassium channels provide an antiparkinsonian effect in a 6-OHDA animal model. Neurosciences (Riyadh) 2017, 22: 44–50.
Sun Q, Zang WJ, Chen C. Growth hormone secretagogues reduce transient outward K+ current via phospholipase C/protein kinase C signaling pathway in rat ventricular myocytes. Endocrinology 2010, 151: 1228–1235.
Hoffman DA, Johnston D. Downregulation of transient K+ channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 1998, 18: 3521–3528.
Yang F, Feng L, Zheng F, Johnson SW, Du J, Shen L, et al. GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons. Nat Neurosci 2001, 4: 1071–1078.
Yuan LL, Adams JP, Swank M, Sweatt JD, Johnston D. Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway. J Neurosci 2002, 22: 4860–4868.
Delmas P, Brown DA. Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 2005, 6: 850–862.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (31671054, 31771124 and 81430024), the Postdoctoral Science Foundation of China (2017M610412 and 2018T110666), the Bureau of Science and Technology of Qingdao Municipality, China (17-1-1-44-jch), and the Taishan Scholars Construction Project of Shandong Province, China.
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Xue, B., Li, C., Chang, X. et al. Ghrelin Reduces A-Type Potassium Currents in Dopaminergic Nigral Neurons via the PLC/PKCδ Pathway. Neurosci. Bull. 36, 947–950 (2020). https://doi.org/10.1007/s12264-020-00508-4
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DOI: https://doi.org/10.1007/s12264-020-00508-4