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Short-Term Effect of Autologous Bone Marrow Stem Cells to Treat Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Clinical Trials

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Abstract

Bone marrow stem cells (BMSCs) have been used to treat patient with ST-segment elevation myocardial infarction (STEMI) via intracoronary route. We performed a meta-analysis to evaluate the short-term efficacy and safety of this modality. Seventeen randomized controlled trials (RCTs) of BMSC-based therapy for STEMI, delivered with 9 days of reperfusion and followed up shorter than 12 months, were identified by systematic review. Intracoronary BMSC therapy resulted in an overall significant improvement in left ventricular ejection fraction (LVEF) by 2.74 % (95 % confidence interval (CI) 2.09–3.39, P < 0.00001, I 2 = 84 %) at 3–6-month follow-up and 5.1 % (95 % CI 4.16–6.03, P < 0.00001 and I 2 = 85 %) at 12 months. The left ventricular end-systolic volume (LVESV) and wall motion score index (WMSI) were also reduced at 3–6 months. At 12 months, left ventricular end-diastolic volume (LVEDV), LVESV, and WMSI were significantly reduced in BMSC group. In conclusion, intracoronary BMSC therapy at post-STEMI is safe and effective in patient with acute STEMI.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Cardiology, Bethune First Hospital of Jilin University, #71, Xinmin Street, Changchun, 130021, Jilin, China

    Xiao-qiang Cong & Xin Zhao

  2. The People’s Hospital of Jilin Province, Changchun, China

    Ying Li

  3. The Friendship Hospital of Linjiang, Linjiang, China

    Yan-jian Dai

  4. School of Public Health, Jilin University, Changchun, China

    Ya Liu

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  1. Xiao-qiang Cong
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  2. Ying Li
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  4. Yan-jian Dai
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Correspondence to Xiao-qiang Cong.

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Associate Editor Enrique Lara-Pezzi oversaw the review of this article

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Cong, Xq., Li, Y., Zhao, X. et al. Short-Term Effect of Autologous Bone Marrow Stem Cells to Treat Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Clinical Trials. J. of Cardiovasc. Trans. Res. 8, 221–231 (2015). https://doi.org/10.1007/s12265-015-9621-9

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  • DOI: https://doi.org/10.1007/s12265-015-9621-9

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