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Congenital Dyserythropoietic Anemia Type 1: Report of One Patient and Analysis of Previously Reported Patients Treated with Interferon Alpha

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Abstract

Congenital dyserythropoietic anemias are a rare group of inherited anemias characterized by ineffective erythropoiesis and distinct morphological abnormalities in the erythroblasts. Interferon alpha has been shown to be effective in type 1 congenital dyserythropoietic anemia but the optimal duration of therapy is undefined. We present here a 32-years-old female patient diagnosed with type 1 congenital dyserythropoietic anemia precipitated by pregnancy and treated successfully with a short course of interferon alpha resulting in a durable response. A literature search including PubMed database on previously published articles regarding congenital dyserythropoietic anemia type 1 patients treated with interferon is conducted.

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Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

    Ayse Salihoglu, Tugrul Elverdi, Ahmet Emre Eskazan, Muhlis Cem Ar, Seniz Ongoren, Zafer Baslar & Teoman Soysal

  2. Department of Internal Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

    Deniz Eyice, Isil Bavunoglu & Aydin Tunckale

  3. Department of Histology and Embryology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

    Elif Guzel

  4. Division of Hematopathology, Department of Pathology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

    Nukhet Tuzuner

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  1. Ayse Salihoglu
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  2. Tugrul Elverdi
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  12. Teoman Soysal
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Correspondence to Ayse Salihoglu.

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Salihoglu, A., Elverdi, T., Eskazan, A.E. et al. Congenital Dyserythropoietic Anemia Type 1: Report of One Patient and Analysis of Previously Reported Patients Treated with Interferon Alpha. Indian J Hematol Blood Transfus 32 (Suppl 1), 272–277 (2016). https://doi.org/10.1007/s12288-015-0600-8

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  • DOI: https://doi.org/10.1007/s12288-015-0600-8

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