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The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer

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Abstract

The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various histological types with biological behaviours more suitable for non-surgical modalities has allowed treatment protocols to become more tailored to the disease. In this review we aim to describe and to summarise the current data guiding the management of sinonasal cancer with emphasis on phenotypic variation.

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Acknowledgements

No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole and have given final approval for the version to be published. This article was written by members of the International Head and Neck Scientific Group (http://www.IHNSG.com).

Disclosures

Fernando López, Valerie J. Lund, Carlos Suárez, Carl H. Snyderman, Nabil F. Saba, K. Thomas Robbins, Vincent Vander Poorten, Primož Strojan, William M. Mendenhall, Alessandra Rinaldo and Alfio Ferlito have nothing to disclose.

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This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Fernando López

  2. Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, Oviedo, Spain

    Fernando López & Carlos Suárez

  3. Professorial Unit, Ear Institute, University College London, London, UK

    Valerie J. Lund

  4. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Carl H. Snyderman

  5. Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA

    Nabil F. Saba

  6. Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, ILL, USA

    K. Thomas Robbins

  7. Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium

    Vincent Vander Poorten

  8. Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia

    Primož Strojan

  9. Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA

    William M. Mendenhall

  10. University of Udine School of Medicine, Udine, Italy

    Alessandra Rinaldo

  11. Coordinator of the International Head and Neck Scientific Group, Padua, Italy

    Alfio Ferlito

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  1. Fernando López
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Correspondence to Fernando López.

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López, F., Lund, V.J., Suárez, C. et al. The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer. Adv Ther 34, 2181–2198 (2017). https://doi.org/10.1007/s12325-017-0605-9

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