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Vitamin K supplementation to prevent hemorrhagic morbidity and mortality of newborns in India and China

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Abstract

Background

Vitamin K deficiency bleeding (VKDB) can cause prolonged and bleeding (intracranial hemorrhage) among newborns, which can be life-threatening or lead to long-term morbidity. The aim of this review article is to reiterate empirical evidence to support the argument that vitamin K should be mandatory for newborns in India and China, as well as in other countries with a high burden of neonatal deaths.

Data sources

Studies were integrated from the PubMed/MEDLINE database search, as well as related literature available elsewhere.

Results

Both India and China have been slow in adopting an effective program for administering vitamin K injections to newborns to prevent VKDB-related morbidity and mortality. VKDB cases in China and India have shown inadequate attention to routine use of vitamin K by injection.

Conclusions

While no reliable data are publicly available, the issue of VKDB is at last receiving some attention from the Chinese public health system as well as the Indian government. In both countries, routine vitamin K administration to newborns would prove to be a cost-effective intervention to reduce preventable neonatal morbidity and mortality. VKDB is a global neonatal care issue, including countries where parental resistance is preventing babies from defense against this life-threatening condition.

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References

  1. The Nobel Prize in Physiology or Medicine, 1943. Nobelprize.org. Nobel Media AB 2014. http://www.nobelprize.org/nobel_prizes/medicine/laureates/1943/(accessed April 1, 2015).

    Google Scholar 

  2. Zipursky A. Prevention of vitamin K deficiency bleeding in newborns. Br J Haematol 1999;104:430–437.

    Article  PubMed  CAS  Google Scholar 

  3. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 2015;385:430–440.

    Article  PubMed  Google Scholar 

  4. Shearer MJ, Fu X, Booth SL. Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv Nutr 2012;3:182–195.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Victora CG. Vitamin K deficiency and haemorrhagic disease of the newborn: a public health problem in less developed countries? New York: UNICEF, 1997.

    Google Scholar 

  6. American Academy of Pediatrics Committee on Fetus and Newborn. Controversies concerning vitamin K and the newborn. American Academy of Pediatrics Committee on Fetus and Newborn. Pediatrics 2003;112:191–192.

    Article  Google Scholar 

  7. Tulchinsky TH, Patton MM, Randolph LA, Meyer MR, Linden JV. Mandating vitamin K prophylaxis for newborns in New York State. Am J Public Health 1993;83:1166–1168.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Centers for Disease Control and Prevention. Late Vitamin K Deficiency Bleeding in infants whose parents declined vitamin K prophylaxis—Tennessee, 2013. MMWR Morb Mortal Wkly Rep 2013;62:901–902.

    Google Scholar 

  9. Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC 3rd, Sidonio R. Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth. Pediatr Neurol 2014;50:564–568.

    Article  PubMed  Google Scholar 

  10. The Jerusalem Post, 2014. Parents refusal of routine vitamin K injection after baby’s birth leads to neurosurgery. http://www.jpost.com/landedpages/printarticle.aspx?id=385405 (accessed April 1, 2015).

    Google Scholar 

  11. Eventov-Friedman S, Vinograd O, Ben-Haim M, Penso S, Bar-Oz B, Zisk-Rony RY. Parents’ knowledge and perceptions regarding vitamin K prophylaxis in newborns. J Pediatr Hematol Oncol 2013;35:409–413.

    Article  PubMed  CAS  Google Scholar 

  12. Golding J, Paterson M, Kinlen LJ. Factors associated with childhood cancer in a national cohort study. Br J Cancer 1990;62:304–308.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. IARC Monographs on the evaluation of carcinogenic risks to humans, vol. 76. Some antiviral and antineoplastic drugs, and other pharmaceutical agents. Vitamin K substances. Lyon: IARC Press, 2000: 417–486.

    Google Scholar 

  14. Roman E, Fear NT, Ansell P, Bull D, Draper G, McKinney P, et al. Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies. Br J Cancer 2002;86:63–69.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Fear NT, Roman E, Ansell E, Simpson J, Day N, Eden OB. Vitamin K and childhood cancer: a report from the United Kingdom childhood cancer study. Br J Cancer 2003;89:1228–1231.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Shearer MJ. Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev 2009;23:49–59.

    Article  PubMed  CAS  Google Scholar 

  17. Martín-López JE, Carlos-Gil AM, Rodríguez-López R, Villegas-Portero R, Luque-Romero L, Flores-Moreno S. Prophylactic vitamin K for vitamin K deficiency bleeding of the newborn. Farm Hosp 2011;35:148–155. [In Spanish]

    Article  PubMed  Google Scholar 

  18. Busfield A, McNinch A, Tripp J. Neonatal vitamin K prophylaxis in Great Britain and Ireland: the impact of perceived risk and product licensing on effectiveness. Arch Dis Child 2007;92:754–758.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Puckett R, Offringa M. Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. Cochrane Database Syst Rev 2000;4:CD002776.

    Google Scholar 

  20. Crowther C, Henderson-Smart D. Vitamin K prior to preterm birth for preventing neonatal periventricular hemorrhage. Cochrane Database Syst Rev 2001;1:CD000229.

    Google Scholar 

  21. Darmstadt GL, Bhutta ZA, Cousens S, Adam T, Walker N, de Bernis L, et al. Evidence-based, cost-effective interventions: how many newborn babies can we save? Lancet 2005;365:977–988.

    Article  PubMed  Google Scholar 

  22. Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet 2014;384:347–370.

    Article  PubMed  Google Scholar 

  23. United Nations Children’s Fund. Level and trends in child mortality, report 2014. New York: United Nations Children’s Fund, 2014.

    Google Scholar 

  24. World Health Organization. Fulfilling the health agenda for women and children, the 2014 Report. Geneva: World Health Organization, 2014.

    Google Scholar 

  25. Ministry of Health and family Welfare. Operational Guidelines: injection vitamin K prophylaxis at birth (in facilities). New Delhi: Ministry of Health and family Welfare, 2014.

    Google Scholar 

  26. Ministry of Health and Family Welfare. INAP: India newborn action plan. New Delhi: Ministry of Health and Family Welfare, 2014.

    Google Scholar 

  27. Pooni PA, Singh D, Singh H, Jain BK. Intracranial hemorrhage in late hemorrhagic disease of the newborn. Indian Pediatr 2003;40:243–248.

    PubMed  Google Scholar 

  28. Bang AT, Bang RA, Baitule SB, Reddy MH, Deshmukh MD. Effect of home based neonatal care and management of sepsis on neonatal mortality: field trial in rural India. Lancet 1999;354:1955–1961.

    Article  PubMed  CAS  Google Scholar 

  29. The Ministry of Health, China and Chinese Nutrition Society. Chinese Dietary Guidelines 2007. Acta Nutrimenta Sinica 2008;30:2–18. [In Chinese]

    Google Scholar 

  30. Liu Y, Lin L. Epidemiological studies of the infants haemorrhage disease with vitamin K deficiency from 7 provinces in China. Chinese Journal of Child Health Care 1999;7:221–224. [In Chinese]

    Google Scholar 

  31. Zhang H, Wang W. Analysis of 3970 cases of late vitamin K deficiency bleeding in infancy. Zhongguo Er Tong Bao Jian Za Zhi 2004;12:31–32. [In Chinese]

    Google Scholar 

  32. Wu M, Li C. A study of vitamin K1 on newborns in 126 hospitals nationwide. Third Yangtze River Delta Academic Forum, Zhejiang Province, 2006. [In Chinese]

    Google Scholar 

  33. Lee ACW, Li CH, So KT. Vitamin K Deficiency Bleeding Revisited. HongKong Journal of Pediatrics 2002;7:157–161.

    Google Scholar 

  34. Victora CG, VanHaecke P. Vitamin K prophylaxis in less developed countries: policy issues and relevance to breastfeeding promotion. Am J Public Health 1998;88:203–209.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  35. Danielsson N, Hoa DP, Thang NV, Vos T, Loughnan PM. Intracranial haemorrhage due to late onset vitamin K deficiency bleeding in Hanoi province, Vietnam. Arch Dis Child Fetal Neonatal Ed 2004;89:F546–F550.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  36. United States Agency for International Development. Private Delivery Care in Developing Countries: Trends and Determinants. DHS Working Papers. Demographic and Health Research, United States Agency for International Development, 2010.

    Google Scholar 

  37. Sahni V, Lai FY, MacDonald SE. Neonatal vitamin k refusal and nonimmunization. Pediatrics 2014;134:497–503.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Society for Health and Demographic Surveillance, Suri, Birbhum, 731101, West Bengal, India

    Rajesh Kumar Rai

  2. Braun School Public Health and Community Medicine, Hebrew University-Hadassah, Ein Karem, Jerusalem, Israel

    Jing Luo & Theodore Herzl Tulchinsky

Authors
  1. Rajesh Kumar Rai
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  2. Jing Luo
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  3. Theodore Herzl Tulchinsky
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Correspondence to Rajesh Kumar Rai.

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Rai, R.K., Luo, J. & Tulchinsky, T.H. Vitamin K supplementation to prevent hemorrhagic morbidity and mortality of newborns in India and China. World J Pediatr 13, 15–19 (2017). https://doi.org/10.1007/s12519-016-0062-6

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  • DOI: https://doi.org/10.1007/s12519-016-0062-6

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