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Bisphenol A Induces a Distinct Transcriptome Profile in the Male Fish of the Marine Medaka Oryzias javanicus

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Abstract

While environmental concentration of bisphenol A (BPA) is ubiquitously detected in effluent and surface of freshwater, BPA has also been measured in coastal and marine ecosystems. To understand the effect of waterborne BPA on the transcriptome over time, male fish of the marine medaka Oryzias javanicus were exposed to 76 μg/L of BPA for 72 h. Time-course microarray study identified differentially expressed transcripts upon BPA exposure in the liver tissues in a time-dependent manner. The primary effect of BPA treatment appears to be significantly upregulated mRNA expression of lipid metabolism (e.g. fatty acid process, lipid/lipoprotein biosynthesis and transport, cholesterol regulation), while genes involved in diverse biochemical and physiological processes were downregulated. In particular, vertebrate immunity relevant genes showed strong downregulated patterns across time-courses. This study provides preliminary insights into the transcriptional response of marine medaka male fish to waterborne BPA exposure and suggests a basis for uncovering the mode of action particularly with respect to endocrine disrupting chemicals (EDCs) such as BPA.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Unit of Polar Genomics, Korea Polar Research Institute, Incheon, 21990, Republic of Korea

    Bo-Mi Kim

  2. South Sea Environment Research Center, Korea Institute of Ocean Science and Technology (KIOST), Geoje, 53201, Republic of Korea

    Ye Jin Jo, Nayun Lee, Nayoung Lee, Seonock Woo & Seungshic Yum

  3. Faculty of Marine Environmental Science, University of Science and Technology (UST), Geoje, 53201, Republic of Korea

    Seonock Woo & Seungshic Yum

  4. Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon, 22012, Republic of Korea

    Jae-Sung Rhee

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  1. Bo-Mi Kim
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Correspondence to Jae-Sung Rhee or Seungshic Yum.

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Kim, BM., Jo, Y.J., Lee, N. et al. Bisphenol A Induces a Distinct Transcriptome Profile in the Male Fish of the Marine Medaka Oryzias javanicus. BioChip J 12, 25–37 (2018). https://doi.org/10.1007/s13206-017-2104-0

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  • DOI: https://doi.org/10.1007/s13206-017-2104-0

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