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Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

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Abstract

The recognition and detection of metal ions present in biological and environmental samples have attracted great attention in recent years. Various analytical techniques are used to detect metal ions. Among these, the fluorescence technique is among the emerging methods because of its simplicity, selectivity, and applicability to bioimaging. Thus, this review particularly explores paper-based fluorescence chemosensors involved in metal ion detection. Significantly, the first section addresses relevant research on metal ion detection involving various techniques. In the second section, several sensing strategies such as photoinduced electron transfer, fluorescence resonance energy transfer, intramolecular charge transfer, chelation enhanced fluorescence, excited-state intramolecular proton transfer, and aggregation-induced emission for the detection of target metal ions (aluminum, copper, iron, lead, mercury, and zinc) are investigated. The third section particularly discusses the role of fluorescence sensor materials (e.g., fluorescein, rhodamine, naphthalimide, BODIPY, carbon dots, quantum dots) involved in the detection processes and their advantages and limitations. Overall, this article reviews 90 research articles on paper-based fluorescence chemosensors for metal ion detection published until 2021.

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copyright by Elsevier, 2019 and 2021; Reproduced with permission from [47], copyright by Royal Society of Chemistry, 2016; Reproduced with permission from [48], copyright by American Chemical Society, 2012)

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. NRF-2020R1A2B5B01001971).

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Authors and Affiliations

  1. Department of Industrial Environmental Engineering, College of Industrial Environmental Engineering, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, South Korea

    Rajamanickam Sivakumar

  2. Department of BioNano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, South Korea

    Nae Yoon Lee

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  1. Rajamanickam Sivakumar
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  2. Nae Yoon Lee
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Correspondence to Nae Yoon Lee.

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Sivakumar, R., Lee, N.Y. Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples. BioChip J 15, 216–232 (2021). https://doi.org/10.1007/s13206-021-00026-z

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  • DOI: https://doi.org/10.1007/s13206-021-00026-z

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