Abstract
Glioma is a type of cancer with a very poor prognosis with a survival of around 15 months in the case of glioblastoma multiforme (GBM). In order to advance in personalized medicine, we developed polymeric nanoparticles (PNP) loaded with both SPION (superparamagnetic iron oxide nanoparticles) and doxorubicin (DOX). The former being used for its potential to accumulate the PNP in the tumor under a strong magnetic field and the later for its therapeutic potential. The emulsion solvent and evaporation method was selected to develop monodisperse PNP with high loading efficiency in both SPION and DOX. Once injected in mice, a significant accumulation of the PNP was observed within the tumoral tissue under static magnetic field as observed by MRI leading to a reduction of tumor growth rate.
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Acknowledgments
The authors would like to thank Angers Hospital & University Animal Facility (SCAHU), Plateforme de Recherche en Imagerie et Spectroscopie Multimodales (PRISM-IRM-Angers) for providing access to their facilities.
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This work was supported by the Fundación Caja Navarra and Navarra Government [grant number 411001-41210-4800-322302].
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Conceptualization: Laurent Lemaire and Maria J. Blanco-Prieto; investigation: Edurne Luque-Michel; writing—original draft preparation: Edurne Luque-Michel; writing—review and editing: Laurent Lemaire and Maria J. Blanco-Prieto; funding acquisition: María J. Blanco-Prieto. All authors have read and agreed to the published version of the manuscript.
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Ethics approval and consent to participate: all institutional and national guidelines for the care and use of laboratory animals were followed. Animal care and use were in accordance with the regulations of the French Ministry of Agriculture and approved by the Pays de la Loire Ethics in Animal Experimentation Committee under project number 01858.03.
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Luque-Michel, E., Lemaire, L. & Blanco-Prieto, M.J. SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics. Drug Deliv. and Transl. Res. 11, 515–523 (2021). https://doi.org/10.1007/s13346-020-00880-8
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DOI: https://doi.org/10.1007/s13346-020-00880-8