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Light-related activities of metal-based nanoparticles and their implications on dermatological treatment

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Abstract

Metal-based nanoparticles (MNPs) represent an emerging class of materials that have attracted enormous attention in many fields. By comparison with other biomaterials, MNPs own unique optical properties which make them a potential alternative to conventional therapeutic agents in medical applications. Especially, owing to the easy access to the skin, the use of MNPs based on their optical properties has gained importance for the treatment of a variety of skin diseases. This review provides an insight into the different optical properties of MNPs, including photoprotection, photocatalysis, and photothermal, and highlights their implications in treating skin disorders, with a special emphasis on their use in infection control. Finally, a perspective on the safety concern of MNPs for dermatological use is discussed and analyzed. The information gathered and presented in this review will help the readers have a comprehensive understanding of utilizing the photo-triggered activity of MNPs for the treatment of skin diseases.

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Abbreviations

MNPs:

Metal-based nanoparticles

MOFs:

Metal-organic frameworks

UV:

Ultraviolet

VIS:

Visible

NIR:

Near-infrared

LSPR:

Localized surface plasmon resonance

PTT:

Photothermal therapy

PDT:

Photodynamic therapy

GRASE:

Generally recognized as safe and effective

PMAA:

Poly (methyl acrylic acid)

ROS:

Reactive oxygen species

MEO:

Metal-enhanced 1O2 generation

BSA:

Bovine serum albumin

PMAA:

Poly (methyl acrylic acid)

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Funding

This work was supported by the National Natural Science Foundation of China (No. 81703435).

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, ShenyangShenyang, 110122, China

    Qiuyue Wang, Naiying Chen, Mingming Li, Sicheng Yao, Xinxing Sun & Yang Chen

  2. Department of Sanitary Chemistry, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, 110034, China

    Xun Feng

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  1. Qiuyue Wang
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Contributions

Qiuyue Wang: Writing-original draft; Naiying Chen: Writing—review and editing; Mingming Li: Literature survey; Sicheng Yao: Literature survey; Xinxing Sun: Literature survey; Xun Feng: Conceptualization, Writing—review and editing; Yang Chen: Writing, Funding acquisition, Supervision, Project administration.

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Wang, Q., Chen, N., Li, M. et al. Light-related activities of metal-based nanoparticles and their implications on dermatological treatment. Drug Deliv. and Transl. Res. 13, 386–399 (2023). https://doi.org/10.1007/s13346-022-01216-4

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