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StarD13: a potential star target for tumor therapeutics

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Abstract

StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is either downregulated or completely inhibited, depending on the tumor type. As such, and through the dysregulation of Rho GTPases, this affects adhesion dynamics, actin dynamics, and leads to an increase or a decrease in tumor metastasis depending on the tumor grade and type. Being a key regulatory protein, StarD13 is a potential promising candidate for therapeutic approaches. This paper reviews the key characteristics of this protein and its role in tumor malignancies.

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Acknowledgements

The authors thank the Lebanese American University. The authors were supported by the Lebanese American University, Department of Natural science.

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  1. Leila Jaafar and Zeinab Chamseddine have equally contributed to this work.

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  1. Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Chouran, P.O. Box 13-5053, 1102 2801, Beirut, Lebanon

    Leila Jaafar, Zeinab Chamseddine & Mirvat El-Sibai

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  1. Leila Jaafar
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Jaafar, L., Chamseddine, Z. & El-Sibai, M. StarD13: a potential star target for tumor therapeutics. Human Cell 33, 437–443 (2020). https://doi.org/10.1007/s13577-020-00358-2

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