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Ex vivo evaluation of celecoxib release from ionic liquid-based microemulsions and microemulgels for topical applications

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Abstract

The aim of this study was to introduce new ionic liquid (IL)-based microemulsions and microemulgels as topical delivery systems for celecoxib. Ex-vivo diffusion of celecoxib loaded in IL-based microemulsions and microemulgels through the rat skin by using Franz diffusion cell was investigated and compared with traditional microemulsions. The investigated systems composed of the same nonionic surfactant/co-surfactant of tween-80/transcutol®P, and different oil phases of [BMIM][PF6], [OMIM][PF6] and isopropyl myristate, for construction of ILs/W and O/W microemulsions. The particle size of the ILs/W and O/W microemulsion systems was determined by DLS method. The ex-vivo release results of ILs/W and O/W formulations, at similar conditions, showed that the celecoxib permeability of the ILs/W formulations is more than that of the O/W formulation, either as microemulsion or as microemulgel. As an interesting result, the celecoxib release percent and release rate from the ILs/W systems was more and faster than the O/W system. The kinetic mechanism for ILs/W systems had followed from first-order model and for O/W systems followed Higuchi zero-order model.

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References

  1. K. Ita, Transdermal Drug Delivery: Concepts and Application, 1st edn. (Elsevier, Amsterdam, 2020), pp. 97–122

    Book  Google Scholar 

  2. M.R. Prausnitz, R. Langer, Transdermal drug delivery. Nat. Biotechnol. 26, 1261–1268 (2008)

    Article  CAS  Google Scholar 

  3. P.K. Ghosh, R. Murthy, Microemulsions: a potential drug delivery system. Curr. Drug Deliv. 3, 167–180 (2006)

    Article  CAS  Google Scholar 

  4. A. Salabat, J. Eastoe, K.J. Mutch, R.F. Tabor, Tuning aggregation of microemulsion droplets and silica nanoparticles using solvent mixtures. J. Colloid Interface Sci. 318, 244–251 (2008)

    Article  CAS  Google Scholar 

  5. S.N. Kale, S.L. Deore, Emulsion, micro emulsion and nano emulsion: a review. Syst. Rev. Pharm. 8, 39–47 (2017)

    Article  CAS  Google Scholar 

  6. S. Talegaonkar, A. Azeem, F.J. Ahmad, R.K. Khar, S.A. Pathan, Z.I. Khan, Microemulsions: a novel approach to enhanced drug delivery. Recent Pat. Drug Deliv. Formul. 2, 238–257 (2008)

    Article  CAS  Google Scholar 

  7. T. Shukla, N. Upmanyu, M. Agrawal, S. Saraf, S. Saraf, A. Alexander, Biomedical applications of microemulsion through dermal and transdermal route. Biomed. Pharmacother. 108, 1477–1494 (2018)

    Article  CAS  Google Scholar 

  8. A. Kajbafvala, A. Salabat, A. Salimi, Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. Pharm. Dev. Technol. 23, 741–750 (2018)

    Article  CAS  Google Scholar 

  9. A. Kajbafvala, A. Salabat, A novel one-step microemulsion method for preparation of quercetin encapsulated poly(methyl methacrylate) nanoparticles. Iran. Polym. J. 26, 651–662 (2017)

    Article  CAS  Google Scholar 

  10. W. Kunz, T. Zemb, A. Harrar, Using ionic liquids to formulate microemulsions: current state of affairs. Curr. Opin. Colloid Interface Sci. 17, 205–211 (2012)

    Article  CAS  Google Scholar 

  11. T. Kusano, K. Fujii, K. Hashimoto, M. Shibayama, Water-in-ionic liquid microemulsion formation in solvent mixture of aprotic and protic imidazolium-based ionic liquids. Langmuir 30, 11890–11896 (2014)

    Article  CAS  Google Scholar 

  12. F. Mirhosseini, A. Salabat, Ionic liquid based microemulsion method for fabrication of poly(methyl methacrylate)-TiO2 nanocomposite as highly efficient visible light photocatalyst. RSC Adv. 5, 12536–12545 (2015)

    Article  Google Scholar 

  13. Q. Li, X. Huang, Formation of 1-butyl-3-methylimidazolium bis(2-ethyl-1-hexyl)sulfosuccinate stabilized water-in-1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide microemulsion and the effects of additives. J. Solut. Chem. 46, 1792–1804 (2017)

    Article  CAS  Google Scholar 

  14. A.R. Hajipour, F. Rafiee, Basic ionic liquids. A short review. J. Iran. Chem. Soc. 6, 647–678 (2009)

    Article  CAS  Google Scholar 

  15. S. Khazalpour, M. Yarie, E. Kianpour, A. Amani, S. Asadabadi, J. Yousefi, M. Rezaeivala, S. Azizian, M.A. Zolfigol, Applications of phosphonium-based ionic liquids in chemical processes. J. Iran. Chem. Soc. 17, 1775–1917 (2020)

    Article  CAS  Google Scholar 

  16. M. Moniruzzaman, M. Tamuraa, Y. Taharaa, N. Kamiya, M. Goto, Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: characterization and cytotoxicity evaluation. Int. J. Pharm. 400, 243–250 (2010)

    Article  CAS  Google Scholar 

  17. A. Froelich, T. Osmałek, A. Snela, P. Kunstman, B. Jadach, M. Olejniczak, G. Roszak, W. Białas, Novel microemulsion-based gels for topical delivery of indomethacin: formulation, physicochemical properties and in vitro drug release studies. J. Colloid Interface Sci. 507, 323–336 (2017)

    Article  CAS  Google Scholar 

  18. Y. Poh, S. Ng, K. Ho, Formulation and characterization of 1-ethyl-3-methylimidazolium acetate-in-oil microemulsions as the potential vehicle for drug delivery across the skin barrier. J. Mol. Liq. 273, 339–345 (2019)

    Article  CAS  Google Scholar 

  19. S. Goindi, P. Arora, N. Kumar, A. Puri, Development of novel ionic liquid-based microemulsion formulation for dermal delivery of 5-fluorouracil. AAPS PharmSciTech 15, 810–821 (2014)

    Article  CAS  Google Scholar 

  20. S. Goindi, R. Kaur, R. Kaur, An ionic liquid-in-water microemulsion as a potential carrier for topical delivery of poorly water soluble drug: development, ex vivo and in vivo evaluation. Int. J. Pharm. 495, 913–923 (2015)

    Article  CAS  Google Scholar 

  21. E. Parsi, A. Salabat, Comparison of O/W and IL/W microemulsion systems as potential carriers of sparingly soluble celecoxib drug. J. Solut. Chem. 49, 68–82 (2020)

    Article  CAS  Google Scholar 

  22. N. Subramanian, S.K. Ghosal, S.P. Moulik, Topical delivery of celecoxib using microemulsion. Acta Pol. Pharm. 61, 335–341 (2004)

    CAS  PubMed  Google Scholar 

  23. S.M. Soleiman, N.S. Abel Malek, O.E. Gazayerly, A.A. Abel Rehim, Formulation of microemulsion gel systems for transdermal delivery of celecoxib: in vitro permeation, anti-inflammatory activity and skin irritation tests. Drug Discov. Ther. 4, 459–471 (2010)

    Google Scholar 

  24. A.M. Ayoub, M.M. Ibrahim, M.H. Abdallah, M.A. Mahdy, Intranasal microemulgel as surrogate carrier to enhance low oral bioavailability of sulpiride. Int. J. Pharm. Pharm. Sci. 8, 188–197 (2016)

    Article  CAS  Google Scholar 

  25. H.K. Patel, B.S. Barot, P.B. Parejiya, P.K. Shelat, A. Shukla, Topical delivery of clobetasol propionate loaded microemulsion based gel for effective treatment of vitiligo: ex vivo permeation and skin irritation studies. Colloids Surf. B 102, 86–94 (2013)

    Article  CAS  Google Scholar 

  26. Y.S. Rhee, J.G. Choi, E.S. Park, S.C. Chi, Transdermal delivery of ketoprofen using microemulsions. Int. J. Pharm. 228, 161–170 (2001)

    Article  CAS  Google Scholar 

  27. C.S. Asbill, B.B. Michniak, Percutaneous penetration enhancers: local versus transdermal activity. Pharm. Sci. Technol. Today 3, 36–41 (2000)

    Article  CAS  Google Scholar 

  28. R. Pramanik, S. Sarkar, C. Ghatak, P. Setua, V. Rao, N. Sarkar, Effect of water on the solvent relaxation dynamics in an ionic liquid containing microemulsion of 1-butyl-3-imidalium tetrafluoroborate/TritonX-100/cyclohexane. Chem. Phys. Lett. 490, 154–158 (2010)

    Article  CAS  Google Scholar 

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Acknowledgements

The financial support from Arak University Research Council is gratefully acknowledged (Grant No. 97-37).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Arak University, 38156-8-8349, Arāk, Iran

    Alireza Salabat & Elham Parsi

  2. Institute of Nanosciences and Nanotechnology, Arak University, 38156-8-8349, Arāk, Iran

    Alireza Salabat

Authors
  1. Alireza Salabat
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  2. Elham Parsi
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Correspondence to Alireza Salabat.

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Salabat, A., Parsi, E. Ex vivo evaluation of celecoxib release from ionic liquid-based microemulsions and microemulgels for topical applications. J IRAN CHEM SOC 18, 1355–1361 (2021). https://doi.org/10.1007/s13738-020-02122-7

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  • DOI: https://doi.org/10.1007/s13738-020-02122-7

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