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Stock price reaction to the drug development setbacks in the pharmaceutical industry

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Abstract

Background

Investments in pharmaceutical companies remain challenging due to the inherent uncertainties of risk assessment.

Objectives

Our paper aims to assess the impact of the drug development setbacks (DDS) on the stock price of pharmaceutical companies while taking into account the company’s financial situation, pipeline size and trend of the stock price before the DDS.

Methods

The model-based clustering based on finite Gaussian mixture modeling was employed to identify the clusters of pharmaceutical companies with homogenous parameters. An artificial neural network was constructed to aid the prediction of the positive mean rate of return 120 days after the DDS.

Results

Our results reveal that a higher pipeline size and a lower rate of return before the DDS, as well as a lower ratio of the market value of the equity and the book value of the total liabilities, are associated with a positive mean rate of return 120 days after the DDS.

Conclusion

In general, the DDS have a negative impact on the company’s stock price, but this risk can be minimized by investors choosing the companies that satisfy certain criteria.

The higher pipeline size(spip) and lower rate of return before (srr) the drug development setback (DDS) and the Market Value of Equity/Book Value of Total Liabilities ratio (sx4) are associated with a positive mean rate of return 120 days after the DDS.

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available upon request.

Code availability

R software was used. Script is available upon request.

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Authors and Affiliations

  1. Laboratory of Preclinical Drug Investigation, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Silvijus Abramavičius & Edgaras Stankevičius

  2. School of Economics and Business, Kaunas University of Technology, Kaunas, Lithuania

    Alina Stundžienė

  3. Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Laura Korsakova

  4. Institute of Mechatronics, Kaunas University of Technology, Kaunas, Lithuania

    Mantas Venslauskas

Authors
  1. Silvijus Abramavičius
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  2. Alina Stundžienė
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  3. Laura Korsakova
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  4. Mantas Venslauskas
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  5. Edgaras Stankevičius
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Contributions

conceptualization, S.A., L.M., M.V. and E.S.; methodology, S.A., M.V. and A.S.; software, S.A., M.V.; validation, S.A. and A.S.; formal analysis, L.M. and E.S.; investigation, S.S. and A.S.; resources, M.V., S.A.; preparation of paper, M.V., E.S.; paper review and editing, A.S.; visualization, A.S.; supervision, S.A.

Corresponding author

Correspondence to Silvijus Abramavičius.

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Silvijus Abramavičius and Alina Stundžienė Shared first authorship

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Abramavičius, S., Stundžienė, A., Korsakova, L. et al. Stock price reaction to the drug development setbacks in the pharmaceutical industry. DARU J Pharm Sci 29, 1–11 (2021). https://doi.org/10.1007/s40199-020-00349-6

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  • DOI: https://doi.org/10.1007/s40199-020-00349-6

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