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Shiitake Mushroom Dermatitis: A Review

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An Erratum to this article was published on 01 October 2016

Abstract

Shiitake mushroom dermatitis is a cutaneous reaction caused by the consumption of raw or undercooked shiitake mushrooms. Symptoms include linear erythematous eruptions with papules, papulovesicles or plaques, and severe pruritus. It is likely caused by lentinan, a heat-inactivated beta-glucan polysaccharide. Cases were initially reported in Japan but have now been documented in other Asian countries, North America, South America, and Europe, as this mushroom is now cultivated and consumed worldwide. Shiitake mushroom dermatitis may result from mushroom ingestion or from handling, which can result in an allergic contact dermatitis.

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References

  1. Nakamura T. Toxicoderma caused by shiitake (Lentinus edodes). Jpn J Clin Dermatol. 1977;31:65–8.

    Google Scholar 

  2. Royse D. A Global perspective on the high five: Agaricus, Pleurotus, Lentinula, Auricularia & Flammulina. In: Proceedings of the 8th International Conference on Mushroom Biology and Mushroom Products, New Delhi, 2014.

  3. Ina K, Kataoka T, Ando T. The use of lentinan for treating gastric cancer. Anticancer Agents Med Chem. 2013;13:681–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis. 1992;27:65–70.

    Article  CAS  PubMed  Google Scholar 

  5. Hamer SE, Kulkarni K, Cohen SN. Shiitake dermatitis with oral ulceration and pustules. Clin Exp Dermatol. 2015;40:332–3.

    Article  CAS  PubMed  Google Scholar 

  6. Luber AJ, Ackerman LS. Flagellate shiitake mushroom dermatitis. Dermatol Online J. 2015;21:8.

  7. Mendonca CN, Silva PM, Avelleira JC, Nishimori FS, Cassia Fde F. Shiitake dermatitis. An Bras Dermatol. 2015;90:276–8.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Zampeli VA, Nikolakis G, Zouboulis CC, Lippert U. A 25-year-old woman with widespread severely pruritic linear papules. Hautarzt. 2014;65:908–10.

    Article  CAS  PubMed  Google Scholar 

  9. Poppe LM, Anders D, Kneitz H, Brocker EB, Benoit S. Flagellate dermatitis caused by shiitake mushrooms. An Bras Dermatol. 2012;87:463–5.

    Article  PubMed  Google Scholar 

  10. Ade R, Sukut C, Wiser HJ, Shockman S, Buescher L. Shiitake dermatitis demonstrating Koebner phenomenon. Int J Dermatol. 2015;54:e179–81.

    Article  PubMed  Google Scholar 

  11. Boels D, Landreau A, Bruneau C, Garnier R, Pulce C, Labadie M, et al. Shiitake dermatitis recorded by French Poison Control Centers—new case series with clinical observations. Clin Toxicol (Phila). 2014;52:625–8.

    Article  CAS  Google Scholar 

  12. Aalto-Korte K, Susitaival P, Kaminska R, Makinen-Kiljunen S. Occupational protein contact dermatitis from shiitake mushroom and demonstration of shiitake-specific immunoglobulin E. Contact Dermatitis. 2005;53:211–3.

    Article  CAS  PubMed  Google Scholar 

  13. Sastre J, Ibanez MD, Lopez M, Lehrer SB. Respiratory and immunological reactions among shiitake (Lentinus edodes) mushroom workers. Clin Exp Allergy. 1990;20:13–9.

    Article  CAS  PubMed  Google Scholar 

  14. Takeshita K, Hayashi S, Tani M, Kando F, Saito N, Endo M. Monocyte function associated with intermittent lentinan therapy after resection of gastric cancer. Surg Oncol. 1996;5:23–8.

    Article  CAS  PubMed  Google Scholar 

  15. Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. Shiitake dermatitis: a report of 3 cases and review of the literature. Cutis. 2013;91:287–90.

    PubMed  Google Scholar 

  16. Hyry H, Kariniemi AL. Shiitake dermatitis: shiitake mushrooms must be cooked before their use. Duodecim. 1998;114:555–7.

    CAS  PubMed  Google Scholar 

  17. Kopp T, Mastan P, Mothes N, Tzaneva S, Stingl G, Tanew A. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Clin Exp Dermatol. 2009;34:e910–3.

    Article  CAS  PubMed  Google Scholar 

  18. Adriano AR, Acosta ML, Azulay DR, Quiroz CD, Talarico SR. Shiitake dermatitis: the first case reported in Brazil. An Bras Dermatol. 2013;88:417–9.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Ricar J, Pizinger K, Cetkovska P. Shiitake dermatitis: a distinctive clinical entity. Int J Dermatol. 2013;52:1620–1.

    Article  PubMed  Google Scholar 

  20. Karanovic S, George S, Topham E. Don’t miss shiitake dermatitis: a case report. Br J Gen Pract. 2014;64:426–7.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hamer S, Rabindranathnambi R. A wide-spread flagellate dermatitis. BMJ Case Rep. 2013;2013:bcr2012007682.

    PubMed  PubMed Central  Google Scholar 

  22. Garg S, Cockayne SE. Shiitake dermatitis diagnosed after 16 years! Arch Dermatol. 2008;144:1241–2.

    Article  PubMed  Google Scholar 

  23. Soo JK, Pearson IC, Misch KJ. A case of flagellation. Clin Exp Dermatol. 2007;32:339–40.

    Article  CAS  PubMed  Google Scholar 

  24. Mak RK, Wakelin SH. Shiitake dermatitis: the first case reported from a European country. Br J Dermatol. 2006;154:800–1.

    Article  CAS  PubMed  Google Scholar 

  25. Girard C, Bessis D. Flagellate dermatitis. Shiitake dermatitis (toxicoderma). Arch Dermatol. 2010;146:1301–6.

    Article  PubMed  Google Scholar 

  26. Herault M, Waton J, Bursztejn AC, Schmutz JL, Barbaud A. Shiitake dermatitis now occurs in France. Ann Dermatol Venereol. 2010;137:290–3.

    Article  CAS  PubMed  Google Scholar 

  27. Hiernickel C, Metz S, Elsner P. Shiitake dermatitis: an impressive case report. J Dtsch Dermatol Ges. 2015;13:455–6.

    PubMed  Google Scholar 

  28. Czarnecka AB, Kreft B, Marsch W. Flagellate dermatitis after consumption of shiitake mushrooms. Postepy Dermatol Alergol. 2014;31:187–90.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Haas N, Vogt R, Sterry W. Shiitake dermatitis: flagellate dermatitis after eating mushrooms. Hautarzt. 2001;52:132–5.

    Article  CAS  PubMed  Google Scholar 

  30. Lippert U, Martin V, Schwertfeger C, Junghans V, Ellinghaus B, Fuchs T. Shiitake dermatitis. Br J Dermatol. 2003;148:178–9.

    Article  CAS  PubMed  Google Scholar 

  31. Maier T, Herzinger T. Linear dermatitis due to shiitake mushrooms. Hautarzt. 2007;58:1021–2.

    Article  CAS  PubMed  Google Scholar 

  32. Scheiba N, Andrulis M, Helmbold P. Treatment of shiitake dermatitis by balneo PUVA therapy. J Am Acad Dermatol. 2011;65:453–5.

    Article  PubMed  Google Scholar 

  33. Wagner G, Sachse MM. Linear grouped erythema and papules on the upper trunkand decollete. Shiitake dermatitis. J Dtsch Dermatol Ges. 2011;9:555–7.

    Article  PubMed  Google Scholar 

  34. Corazza M, Zauli S, Ricci M, Borghi A, Pedriali M, Mantovani L, et al. Shiitake dermatitis: toxic or allergic reaction? J Eur Acad Dermatol Venereol. 2015;29:1449–51.

    Article  CAS  PubMed  Google Scholar 

  35. Hanada K, Hashimoto I. Flagellate mushroom (shiitake) dermatitis and photosensitivity. Dermatology. 1998;197:255–7.

    Article  CAS  PubMed  Google Scholar 

  36. Baran W, Batycka-Baran A, Maj J, Szepietowski JC. Shiitake dermatitis—now also in Poland. Acta Derm Venereol. 2015;95:102–3.

    Article  PubMed  Google Scholar 

  37. Loo HV, Oon HH. Flagellate dermatitis following consumption of shiitake mushroom. Dermatol Rep. 2011;3:e21.

    Article  Google Scholar 

  38. Diaz-Corpas T, Mateu-Puchades A, Coll-Puigserver MN, Marquina-Vila A. Flagellate dermatitis after eating shiitake mushrooms. Actas Dermosifiliogr. 2011;102:830–2.

    Article  CAS  PubMed  Google Scholar 

  39. Lapresta A, de Miguel R, Sanchez-Moya AI, Robuschi F, Cardona C. Shiitake dermatitis in a Spanish patient. Dermatol Online J. 2011;17:16.

    PubMed  Google Scholar 

  40. Lopez-Nunez M, Jaka-Moreno A, Tuneu-Valls A. Pregnant woman with flagellate erythema. Actas Dermosifiliogr. 2012;103:155–6.

    Article  CAS  PubMed  Google Scholar 

  41. Garrido Colmenero C, Nogueras Morillas P, Blasco Morente G, Arias Santiago S. Flagellate dermatitis caused by shiitake. Med Clin (Barc). 2015;144:e7.

    Article  Google Scholar 

  42. Carlson S, Stuckert J, Nedorost S. Shiitake mushroom dermatitis. Dermatitis. 2010;21:290–1.

    PubMed  Google Scholar 

  43. Adler MJ, Larsen WG. Clinical variability of shiitake dermatitis. J Am Acad Dermatol. 2012;67:e140–1.

    Article  PubMed  Google Scholar 

  44. Wang AS, Barr KL, Jagdeo J. Shiitake mushroom-induced flagellate erythema: a striking case and review of the literature. Dermatol Online J. 2013;19:5.

    PubMed  Google Scholar 

  45. Uslu U, Linkner RV. Shiitake mushroom dermatitis. Cutis. 2015;95:E11–2.

    PubMed  Google Scholar 

  46. Duckworth G. Meadow grass dermatitis. Br J Dermatol Syph. 1946;58:32.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. University of Nebraska Medical Center, College of Medicine, Omaha, NE, USA

    Mathew Paul Stephany & Nancy Stefanie Handler

  2. Dermatology Department, Rutgers New Jersey Medical School, Newark, NJ, USA

    Stella Chung, Marc Zachary Handler, Glenn A. Handler & Robert A. Schwartz

Authors
  1. Mathew Paul Stephany
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  2. Stella Chung
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  3. Marc Zachary Handler
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  4. Nancy Stefanie Handler
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Corresponding author

Correspondence to Marc Zachary Handler.

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Funding

No funding was received for the preparation of this review.

Conflict of interest

Mr. Stephany, Ms. Chung, Ms. Handler, Drs. Handler MZ, Handler G, and Schwartz have no conflicts of interest.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s40257-016-0225-1.

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Stephany, M.P., Chung, S., Handler, M.Z. et al. Shiitake Mushroom Dermatitis: A Review. Am J Clin Dermatol 17, 485–489 (2016). https://doi.org/10.1007/s40257-016-0212-6

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  • DOI: https://doi.org/10.1007/s40257-016-0212-6

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