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Cost–Utility Analyses of Interventions for Informal Carers: A Systematic and Critical Review

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Abstract

Background

Demographic and epidemiological changes place an increasing reliance on informal carers. Some support programmes exist, but funding is often limited. There is a need for economic evaluation of interventions for carers to assist policymakers in prioritizing carer support.

Objective

Our aim was to systematically review and critically appraise cost–utility analyses of interventions for informal carers, in order to assess the methods employed and the quality of the reporting.

Methods

A systematic review of databases was conducted using MEDLINE, Embase, PsycINFO, and EconLit of items published between 1950 and February 2019. Published studies were selected if they involved a cost–utility analysis of an intervention mainly or jointly targeting informal carers. The reporting quality of economic analyses was evaluated using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement.

Results

An initial set of 1364 potentially relevant studies was identified. The titles and the abstracts were then screened, resulting in the identification of 62 full-text articles that warranted further assessment of their eligibility. Of these, 20 economic evaluations of informal carer interventions met the inclusion criteria. The main geographical area was the UK (n = 11). These studies were conducted in mental and/or behavioural (n = 15), cardiovascular (n = 3) or cancer (n = 2) clinical fields. These cost–utility analyses were based on randomized clinical trials (n = 16) and on observational studies (n = 4), of which only one presented a Markov model-based economic evaluation. Four of the six psychological interventions were deemed to be cost effective versus two of the four education/support interventions, and four of the nine training/support interventions. Two articles achieved a CHEERS score of 100% and nine of the economic evaluations achieved a score of 85% in terms of the CHEERS criteria for high-quality economic studies.

Conclusions

Our critical review highlights the lack of cost–utility analyses of interventions to support informal carers. However, it also shows the relative prominence of good reporting practices in these analyses that other studies might be able to build on.

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Notes

  1. https://eurocarers.org/.

  2. https://internationalcarers.org/carer-facts/global-carer-stats/.

  3. https://eurocarers.org/download/6372/.

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Acknowledgements

This research was supported by the National Solidarity Fund for Autonomy project “PERRIER-AAP16-Hand7-25” through the call for proposals launched by the IReSP in 2016. H.A. is supported by an NIHR Career Development Fellowship (CDF-2015-08-025) to work on “Techniques to include carer quality of life in economic evaluation”. The authors are grateful to Sophie Domingues-Montanari who helped with the final editing of the manuscript. The authors also thank the reviewers, Salah Ghabri and Sandy Tubeuf, for their valuable comments.

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Authors and Affiliations

  1. University of Lyon, Centre Léon Bérard, GATE L-SE UMR 5824, Lyon, France

    Wilfried Guets & Lionel Perrier

  2. University of Birmingham, Birmingham, UK

    Hareth Al-Janabi

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  1. Wilfried Guets
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  2. Hareth Al-Janabi
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  3. Lionel Perrier
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Contributions

Concept and overall approach: WG, HA and LP. Search strategy: WG, HA and LP. Review of search results and selection of studies: WG, HA and LP. Critical appraisal: WG and LP. Interpretation of results: WG, HA and LP. Drafting of the manuscript: WG. Critical review of the manuscript: WG and LP.

Corresponding author

Correspondence to Wilfried Guets.

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Funding

National Solidarity Fund for Autonomy project “PERRIER-AAP16-Hand7-25” through the call for proposals launched by the IReSP.

Conflict of interest

The Fondation France Répit supported the travel and the registration of Wilfried Guets to the ISPOR Europe 2018 and ISPOR Europe 2019 conferences, as well as the travel and the accommodation of Wilfried Guets to the University of Birmingham. The Fondation France Répit also supported the travel and the registration of Lionel Perrier for the ISPOR Europe 2019 conference. Hareth Al-Janabi declares that he has no conflicts of interest.

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Guets, W., Al-Janabi, H. & Perrier, L. Cost–Utility Analyses of Interventions for Informal Carers: A Systematic and Critical Review. PharmacoEconomics 38, 341–356 (2020). https://doi.org/10.1007/s40273-019-00874-6

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