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Functional Electrospun Fibers for Local Therapy of Cancer

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Abstract

Despite great efforts and advancement in the treatment of cancer, tumor recurrence and metastasis remain significant challenges and demand novel therapy strategies. Recently, advances in biomaterials and drug delivery systems have facilitated the development of the local therapy of cancer, among which electrospun nanofibrous scaffolds show great promise owing to their porous structure, relatively large surface area, high drug loading capacity, similarity with the native extracellular matrix, and possibility of the combination of various therapies. Here, we review this rapidly developing field of electrospun nanofibrous scaffolds as a drug delivery system for cancer local therapy, in particular addressing stimuli-responsive drug release, as well as its combination with stem cell and immune therapy. Challenges and future perspectives are also discussed.

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Copyright © 2017 Scientific Reports

Fig. 2

(Reproduced with permission [50]. Copyright © 2015 Colloids and Surfaces B: Biointerfaces)

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(Reproduced with permission [55]. Copyright © 2018 Advanced Healthcare Materials)

Fig. 4

(Reproduced with permission [65]. Copyright © 2017 ChemMedChem)

Fig. 5

(Reproduced with permission [69]. Copyright © 2018 MRS Advances)

Fig. 6

(Reproduced with permission [73]. Copyright © 2015 Advanced Healthcare Materials)

Fig. 7

(Reproduced with permission [19]. Copyright © 2018 Advanced Functional Materials)

Fig. 8

(Reproduced with permission [98]. Copyright © 2017 ACS Nano)

Fig. 9

(Reproduced with permission [104]. Copyright © 2019 Small)

Fig. 10

(Reproduced with permission [115]. Copyright © 2018 Materials Horizons)

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Acknowledgements

This work was supported by the Natural Science Foundation of China (81930051 and 51873107) and Shanghai Talent Development Fund (2018099).

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  1. Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People’s Republic of China

    Jingwen Zhao & Wenguo Cui

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  1. Jingwen Zhao
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  2. Wenguo Cui
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Correspondence to Wenguo Cui.

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Zhao, J., Cui, W. Functional Electrospun Fibers for Local Therapy of Cancer. Adv. Fiber Mater. 2, 229–245 (2020). https://doi.org/10.1007/s42765-020-00053-9

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