Abstract
Background
Sports injuries are very common, and the management demands high degrees of skills and best techniques for an early return to play. The use of Platelet Rich Plasma (PRP) injections in the treatment of tendon, muscle and ligament injuries has become popular. This study observes the outcomes of PRP injections in sports injuries.
Methods
Forty-eight athletes (mean age 29.93 ± 8.48, Male: 37, Female: 11) presenting to a sports medicine centre with different sports injuries with symptom duration (2.81 ± 1.94) months were given PRP injections (single or multiple) four weeks apart with maximum number of injections up to three depending upon the clinical condition, Pre and Post VAS scores. Specific rehabilitation program was administered and compliance was graded by Sports Injury Rehabilitation Adherence Scale (SIRAS). A 1 year follow-up of cases was done for assessing player satisfaction and return to play.
Results
Pre-procedure (7.25 ± 0.70) and post-procedure (2.42 ± 0.74) VAS score for all athletes showed significant difference with a p value at 0.0001. The average number of injections was 1.35 ± 1.41 with 72.91% requiring only one injection while 18.75% and 8.33% required two and three injections, respectively.
Conclusion
Athletes who required a single injection for acute injuries of lower grade returned to sports activity earlier than those who required multiple injections for chronic injuries. PRP injection has optimal effects on sports injuries not responding to conservative management
Similar content being viewed by others
References
Anitua, E., Andia, I., Ardanza, B., Nurden, P., & Nurden, A. T. (2004). Autologous platelets as a source of proteins for healing and tissue regeneration. Thrombosis and Haemostasis, 91(1), 4–15.
de Mos, M., van der Windt, A. E., Jahr, H., van Schie, H. T. M., Weinans, H., Verhaar, J. A. N., et al. (2008). Can platelet-rich plasma enhance tendon repair?: a cell culture study. American Journal of Sports Medicine, 36(6), 1171–1178.
Hayem, G. (2001). The normal tendon and the abnormal tendon. Joint Bone Spine, 68(1), 19–25.
Fenwick, S. A., Hazleman, B. L., & Riley, G. P. (2002). The vasculature and its role in the damaged and healing tendon. Arthritis Research & Therapy, 4(4), 252.
Raeissadat, S. A., Sedighipour, L., Rayegani, S. M., Bahrami, M. H., Bayat, M., Rahimi, R. (2014). Effect of Platelet-Rich Plasma (PRP) versus Autologous Whole Blood on Pain and Function Improvement in Tennis Elbow: A Randomized Clinical Trial [Internet]. Vol. 2014, Pain Research and Treatment. Hindawi. p. e191525. Available from: https://www.hindawi.com/journals/prt/2014/191525/ Accessed 26 May 2020.
Heijink, A., Gomoll, A. H., Madry, H., Drobnič, M., Filardo, G., Espregueira-Mendes, J., et al. (2012). Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy, 20(3), 423–435.
Hart, R., Safi, A., Komzák, M., Jajtner, P., Puskeiler, M., & Hartová, P. (2013). Platelet-rich plasma in patients with tibiofemoral cartilage degeneration. Archives of Orthopaedic and Trauma Surgery, 133(9), 1295–1301.
Jang, S.-J., Kim, J.-D., & Cha, S.-S. (2013). Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis. European Journal of Orthopaedic Surgery & Traumatology, 23(5), 573–580.
Sánchez, M., Anitua, E., Azofra, J., Andía, I., Padilla, S., & Mujika, I. (2007). Comparison of surgically repaired achilles tendon tears using platelet-rich fibrin matrices. American Journal of Sports Medicine, 35(2), 245–251.
Weber, S. C., Kauffman, J. I., Parise, C., Weber, S. J., & Katz, S. D. (2012). Platelet-rich fibrin matrix in the management of arthroscopic repair of the rotator cuff: a prospective, randomized, double-blinded study. The American Journal of Sports Medicine. https://doi.org/10.1177/0363546512467621.
Eppley, B. L., Woodell, J. E., & Higgins, J. (2004). Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plastic and Reconstructive Surgery., 114, 1502–1508.
Sampson, S., Gerhardt, M., & Mandelbaum, B. (2008). Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Current Reviews in Musculoskeletal Medicine, 1(3–4), 165–174.
Kelly, A.-M. (2001). The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. Emergency Medicine Journal, 18(3), 205–207.
Kolt, G. S., Brewer, B. W., Pizzari, T., Schoo, A. M. M., & Garrett, N. (2007). The sport injury rehabilitation adherence scale: a reliable scale for use in clinical physiotherapy. Physiotherapy, 93(1), 17–22.
Brewer, B. W., Van Raalte, J. L., Cornelius, A. E., Petitpas, A. J., Sklar, J. H., Pohlman, M. H., et al. (2000). Psychological factors, rehabilitation adherence, and rehabilitation outcome after anterior cruciate ligament reconstruction. Rehabilitation Psychology, 45(1), 20–37.
Engebretsen, L., Steffen, K., Alsousou, J., Anitua, E., Bachl, N., Devilee, R., et al. (2010). IOC consensus paper on the use of platelet-rich plasma in sports medicine. British Journal of Sports Medicine, 44(15), 1072–1081.
Örsçeli̇K, A., & Yildiz, Y. (2015). Comparison of single and triple platelet rich plasma injections in the treatment of patellofemoral pain syndrome. TurkiyeKlinikleri Journal of Medical Sciences, 35(2), 78–87.
Rha, D., Park, G.-Y., Kim, Y.-K., Kim, M. T., & Lee, S. C. (2012). Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial. Clinical Rehabilitation. https://doi.org/10.1177/0269215512448388.
Kesikburun, S., Tan, A. K., Yılmaz, B., Yaşar, E., & Yazıcıoğlu, K. (2013). Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. The American Journal of Sports Medicine. https://doi.org/10.1177/0363546513496542.
Shams, A., El-Sayed, M., Gamal, O., & Ewes, W. (2016). Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears. European Journal of Orthopaedic Surgery & Traumatology, 26(8), 837–842.
Grassi, A., Napoli, F., Romandini, I., Samuelsson, K., Zaffagnini, S., Candrian, C., et al. (2018). Is platelet-rich plasma (PRP) effective in the treatment of acute muscle injuries? a systematic review and meta-analysis. Sports Medicine (Auckland, N. Z.), 48(4), 971–989.
Ekstrand, J., Hägglund, M., & Waldén, M. (2011). Epidemiology of muscle injuries in professional football (soccer). American Journal of Sports Medicine, 39(6), 1226–1232.
Gaweda, K., Tarczynska, M., & Krzyzanowski, W. (2010). Treatment of achillestendinopathy with platelet-rich plasma. International Journal of Sports Medicine, 31(08), 577–583.
de Vos, R. J., Weir, A., van Schie, H. T. M., Bierma-Zeinstra, S. M. A., Verhaar, J. A. N., Weinans, H., et al. (2010). Platelet-Rich plasma injection for chronic achillestendinopathy: a randomized controlled trial. JAMA, 303(2), 144.
Owens, R. F., Ginnetti, J., Conti, S. F., & Latona, C. (2011). Clinical and magnetic resonance imaging outcomes following platelet rich plasma injection for chronic midsubstanceachillestendinopathy. Foot and Ankle International, 32(11), 1032–1039.
Monto, R. R. (2012). Platelet rich plasma treatment for chronic achillestendinosis. Foot and Ankle International, 33(5), 379–385.
Filardo, G., Kon, E., Di Matteo, B., Pelotti, P., Di Martino, A., & Marcacci, M. (2013). Platelet-rich plasma for the treatment of patellar tendinopathy: clinical and imaging findings at medium-term follow-up. International Orthopaedics (SICOT)., 37(8), 1583–1589.
Kon, E., Filardo, G., Delcogliano, M., Presti, M. L., Russo, A., Bondi, A., et al. (2009). Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper’s knee. Injury, 40(6), 598–603.
Lai, M. W. W., & Sit, R. W. S. (2018). Healing of complete tear of the anterior talofibular ligament and early ankle stabilization after autologous platelet rich plasma: a case report and literature review. Archives of Bone Joint Surgery, 6(2), 146–149.
Gallesio, G., Del Fabbro, M., Pol, R., Mortellaro, C., & Mozzati, M. (2015). Conservative treatment with plasma rich in growth factors-endoret for osteoradionecrosis. J Craniofac Surg., 26(3), 731–736.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
Ethical standard statement
This article does not contain any studies with human or animal subjects performed by the any of the authors.
Informed consent
For this type of study informed consent is not required.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Arumugam, S., Prakash, A., Janani, G. et al. Platelet-Rich Plasma (PRP) Injection in Sports Injuries. JOIO 55, 484–491 (2021). https://doi.org/10.1007/s43465-020-00349-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s43465-020-00349-3