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Diet and benign ovarian tumors (United States)

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Abstract

Objectives: The relation between benign ovarian tumors (BOTs) and nutrients, primarily dietary fat, was examined using case–control data.

Methods: 746 cases were diagnosed from 1 January 1992 to 31 December 1993. The 404 age- and hospital frequency-matched community controls were identified by random digit dialing. Six hundred seventy-three cases and 351 controls provided dietary information.

Results: The risk of BOTs was elevated for the highest vs. lowest quartile of intake of total, vegetable, saturated, monounsaturated, and polyunsaturated fat. The corresponding age-, hospital-, total energy-, and body mass index-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) are 1.3 (0.9–1.9), 1.7 (1.2–2.5), 1.2 (0.8–1.8), 1.3 (0.9–1.8), and 1.6 (1.1–2.3). After adjustment for polyunsaturated fat, the risk of BOTs only remained elevated for vegetable fat (highest vs. lowest quartile OR and 95% CI = 1.4 (0.8–2.3)). Elevated risks were observed for higher intakes of polyunsaturated fat with endometrioid, serous, and teratoma tumors. Higher intakes of vegetable fat, adjusted for polyunsaturated fat, increased the risk of endometrioid, mucinous, and serous tumors. Only the risk of serous BOTs was consistently lower for higher intakes of micronutrients, with the strongest reduction observed for sources of vitamin A. Estimates were not confounded by non-nutrient covariates.

Conclusions: Polyunsaturated and vegetable fat may increase the risk of BOTs, while vitamin A may lower the risk of serous BOTs; however, these findings and lack of associations for other nutrients should be replicated.

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References

  1. Bennington JL, Ferguson BR, Haber SL (1968) Incidence and relative frequency of benign and malignant ovarian neoplasms. Obstet Gynecol 32: 627–632.

    Google Scholar 

  2. Anonymous (1974) Functional ovarian cysts and oral contraceptives. Negative association confirmed surgically. A cooperative study. JAMA 228: 68–69.

    Google Scholar 

  3. Katsube Y, Berg JW, Silverberg SG (1982) Epidemiologic pathology of ovarian tumors: a histopathologic review of primary ovarian neoplasms diagnosed in the Denver Standard Metropolitan Statistical Area, 1 July-31 December 1969 and 1 July-31 December 1979. Int J Gynecol Pathol 1: 3–16.

    Google Scholar 

  4. Westho. C, Clark CJ (1992) Benign ovarian cysts in England and Wales and in the United States. Br J Obstet Gynaecol 99: 329–332.

    Google Scholar 

  5. McKay DG (1962) The origins of ovarian tumors. Clin Obstet Gynecol 5: 1181–1197.

    Google Scholar 

  6. Powell DE, Puls LE, van Nagell JR (1992) Current concepts in epithelial ovarian tumors: does benign to malignant transformation occur? Hum Pathol 23: 846–847.

    Google Scholar 

  7. Vessey M, Metcalfe A, Wells C, McPherson K, Westho. C, Yeates D (1987) Ovarian neoplasms, functional ovarian cysts, and oral contraceptives. Br Med J (Clin Res Ed ) 294: 1518–1520.

    Google Scholar 

  8. Booth M, Beral V, Maconochie N, Carpenter L, Scott C (1992) A case-control study of benign ovarian tumours. J Epidemiol Commun Health 46: 528–531.

    Google Scholar 

  9. Westho. C, Pike M, Vessey M (1988) Benign ovarian teratomas: a population-based case-control study. Br J Cancer 58: 93–98.

    Google Scholar 

  10. Eskenazi B, Warner ML (1997) Epidemiology of endometriosis. Obstet Gynecol Clin N Am 24: 235–258.

    Google Scholar 

  11. Whittemore AS, Harris R, Itnyre J (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer Group. Am J Epidemiol 136: 1184–1203.

    Google Scholar 

  12. Chia.arino F, Parazzini F, La Vecchia C, Ricci E, Crosignani PG (1998) Oral contraceptive use and benign gynecologic conditions. Contraception 57: 11–18.

    Google Scholar 

  13. Parazzini F, La Vecchia C, Negri E, Moroni S, Villa A (1995) Risk factors for benign ovarian teratomas. Br J Cancer 71: 644–646.

    Google Scholar 

  14. Parazzini F, Moroni S, Negri E, La Vecchia C, Mezzopane R, Crosignani PG (1996) Risk factors for seromucinous benign ovarian cysts in northern Italy. J Epidemiol Commun Health 51: 449–452.

    Google Scholar 

  15. Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15: 617–631.

    Google Scholar 

  16. Kato I, Tominaga S, Kuroishi T (1987) Relationship between westernization of dietary habits and mortality from breast and ovarian cancers in Japan. Jpn J Cancer Res 78: 349–357.

    Google Scholar 

  17. Rose DP, Boyar AP, Wynder EL (1986) International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 58: 2363–2371.

    Google Scholar 

  18. Serra-Majem L, La Vecchia C, Ribas-Barba L, et al. (1993) Changes in diet and mortality from selected cancers in southern Mediterranean countries, 1960-1989. Eur J Clin Nutr 47: S25–S34.

    Google Scholar 

  19. Phillips RL (1975) Role of life-style and dietary habits in risk of cancer among seventh-day adventists. Cancer Res 35: 3513–3522.

    Google Scholar 

  20. Phillips RL, Garfinkel L, Kuzma JW, Beeson WL, Lotz T, Brin B (1980) Mortality among California Seventh-Day Adventists for selected cancer sites. J Natl Cancer Inst 65: 1097–1107.

    Google Scholar 

  21. Enstrom JE (1980) Health and dietary practices and cancer mortality among California Mormons. In: Cairns J, Lyon JL, Skolnick M, eds. Banbury Report 4 Cancer Incidence in Defined Populations. New York: Cold Spring Harbor Laboratory, pp. 69–92.

    Google Scholar 

  22. Lyon JL, Gardner JW, West DW (1980) Cancer risk and life-style: cancer among Mormons from 1967-1975. In: Cairns J, Lyon JL SM, eds. Banbury Report 4 Cancer Incidence in Defined Populations. New York: Cold Spring Harbor Laboratory, pp. 3–30.

    Google Scholar 

  23. Byers T, Marshall J, Graham S, Mettlin C, Swanson M (1983) A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst 71: 681–686.

    Google Scholar 

  24. Slattery ML, Schuman KL, West DW, French TK, Robison LM (1989) Nutrient intake and ovarian cancer. Am J Epidemiol 130: 497–502.

    Google Scholar 

  25. Risch HA, Jain M, Marrett LD, Howe GR (1994) Dietary fat intake and risk of epithelial ovarian cancer. J Natl Cancer Inst 86: 1409–1415.

    Google Scholar 

  26. Shu XO, Gao YT, Yuan JM, Ziegler RG, Brinton LA (1989) Dietary factors and epithelial ovarian cancer. Br J Cancer 59: 92–96.

    Google Scholar 

  27. Tzonou A, Hsieh CC, Polychronopoulou A, et al. (1993) Diet and ovarian cancer: a case-control study in Greece. Int J Cancer 55: 411–414.

    Google Scholar 

  28. Mink P, Kushi LH, Sellers T, Sheng W, Folsom A (1996) Dietary risk factors for ovarian cancer: a prospective study of older women. Am J Epidemiol 143: S59.

    Google Scholar 

  29. Kushi LH, Mink PJ, Folsom AR, et al. (1999) Prospective study of diet and ovarian cancer. Am J Epidemiol 149: 21–31.

    Google Scholar 

  30. Cramer DW, Welch WR, Hutchison GB, Willett W, Scully RE (1984) Dietary animal fat in relation to ovarian cancer risk. Obstet Gynecol 63: 833–838.

    Google Scholar 

  31. La Vecchia C, Decarli A, Negri E, et al. (1987) Dietary factors and the risk of epithelial ovarian cancer. J Natl Cancer Inst 79: 663–669.

    Google Scholar 

  32. Engle A, Muscat JE, Harris RE (1991) Nutritional risk factors and ovarian cancer. Nutr Cancer 15: 239–247.

    Google Scholar 

  33. Westho. C, Britton JA, Gammon MD, Wright T, Kelsey JL. Oral contraceptives and benign ovarian tumors. Am J Epidemiol, in press.

  34. Russell P, Bannatyne P (1989) Surgical Pathology of the Ovaries. Edinburgh: Churchill Livingstone.

    Google Scholar 

  35. Waksberg JS (1978) Sampling methods for random digit dialing. J Am Stat Assoc 73: 40–46.

    Google Scholar 

  36. Hartge P, Brinton LA, Rosenthal JF, Cahill JI, Hoover RN, Waksberg JS (1984) Random digit dialing in selecting a population-based control group. Am J Epidemiol 120: 825–833.

    Google Scholar 

  37. Willett W (1990) Nutritional Epidemiology. New York: Oxford University Press.

    Google Scholar 

  38. Howe GR, Hirohata T, Hislop TG, et al. (1990) Dietary factors and risk of breast cancer: combined analysis of twelve case-control studies. J Natl Cancer Inst 82: 561–569.

    Google Scholar 

  39. Hunter DJ, Spiegelman D, Adami H, et al. (1996) Cohort studies of fat intake and the risk of breast cancer-a pooled analysis. N Engl J Med 334: 356–361.

    Google Scholar 

  40. Conover WJ (1980) Practical Nonparametric Statistics, 2nd edn. New York: John Wiley & Sons.

    Google Scholar 

  41. Selvin S (1991) Statistical Analysis of Epidemiologic Data. New York: Oxford University Press.

    Google Scholar 

  42. Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65: 1220S–1228S.

    Google Scholar 

  43. Hosmer DW, Lemeshow S (1989) Applied Logistic Regression. New York: John Wiley & Sons.

    Google Scholar 

  44. Cramer DW, Hutchison GB, Welch WR, Scully RE, Knapp RC (1982) Factors affecting the association of oral contraceptives and ovarian cancer. N Engl J Med 307: 1047–1051.

    Google Scholar 

  45. Kvale G, Heuch I, Nilssen S, Beral V (1988) Reproductive factors and risk of ovarian cancer: a prospective study. Int J Cancer 42: 246–251.

    Google Scholar 

  46. Risch HA, Marrett LD, Jain M, Howe GR (1996) Differences in risk factors for epithelial ovarian cancer by histologic type: results of a case-control study. Am J Epidemiol 144: 363–372.

    Google Scholar 

  47. Kleinbaum DG (1994) Logistic Regression: A Self-Learning Text. New York: Springer-Verlag.

    Google Scholar 

  48. Rose DP (1997) Dietary fatty acids and cancer. Am J Clin Nutr 66: 988S–1003S.

    Google Scholar 

  49. Horrobin DF (1983) The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism. Rev Pure Appl Pharmacol Sci 4: 339–383.

    Google Scholar 

  50. Smith MF (1986) Recent advances in corpus luteum physiology. J Dairy Sci 69: 911–926.

    Google Scholar 

  51. Priddy AR, Killick SR, Elstein M, et al. (1990) The effect of prostaglandin synthetase inhibitors on human preovulatory follicular fluid prostaglandin, thromboxane, and leukotriene concentrations. J Clin Endocrinol Metab 71: 235–242.

    Google Scholar 

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Authors and Affiliations

  1. Division of Environmental Health Science, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA

    Julie A. Britton

  2. Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Carolyn Westhoff

  3. Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, NY, USA

    Carolyn Westhoff, Geoffrey Howe & Marilie D. Gammon

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  1. Julie A. Britton
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  2. Carolyn Westhoff
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  3. Geoffrey Howe
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  4. Marilie D. Gammon
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Britton, J.A., Westhoff, C., Howe, G. et al. Diet and benign ovarian tumors (United States). Cancer Causes Control 11, 389–401 (2000). https://doi.org/10.1023/A:1008921710400

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