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Assessment of Risks of Brodifacoum to Non-target Birds and Mammals in New Zealand

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Abstract

The risks to non-target birds and other wildlife from the use of vertebrate pesticides, including anticoagulant rodenticides, are determined to a significant extent by species' intrinsic susceptibility, and the toxicokinetics of the compounds used. Brodifacoum is highly toxic to birds and mammals. The acute toxicity of brodifacoum to birds in New Zealand varies from <1 mg/kg in pūkeko (Porphyrio p. melanotus), the native swamp hen, to >20 mg/kg in the paradise shelduck (Tadorna variegata). Like other second-generation anticoagulants brodifacoum is strongly bound to vitamin K epoxide reductase and will persist, apparently for at least 6 months, in organs and tissue containing this enzyme, e.g., liver, kidney, and pancreas. The unique toxicokinetics of this class of compound exacerbates the risk of primary and secondary poisoning of non-target species. Vertebrate pest control programmes in New Zealand using bait containing brodifacoum have resulted in the primary and secondary poisoning and sub-lethal contamination of non-target species. These include native raptors, such as the Australasian harrier (Circus approximans) and morepork (Ninox novaeseelandiae), other native birds such as the pūkeko, weka (Gallirallus australis), southern black-backed gull (Larus dominicanus), and kiwi (Apteryx spp.), and introduced mammals, including game animals. There are increasing numbers of reports worldwide of wildlife contamination and toxicosis after the use of second-generation anticoagulants. All pest control activities require careful risk–benefit assessment in view of their potential to cause adverse environmental impact. Monitoring of wildlife for pesticide residues will provide data that can be used to reduce the risk of anticoagulant bioaccumulation and mortality in non-target species.

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References

  • Bachmann, K.A. and Sullivan, T.J. (1983). Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats. Pharmacol. 27, 281–8.

    Google Scholar 

  • Bell, B.D. (1978). The Big South Cape rat irruption. In P.R. Dingwall, I.A.E. Atkinson, and C. Hay (eds) The ecology and control of rodents in New Zealand nature reserves, pp. 33–40. Department of Lands and Survey (Information series no.4), Wellington, New Zealand.

    Google Scholar 

  • Bratt, H. (1987). Difenacoum: Elimination from tissues of rats following administration of a single oral dose. Macclesfield, Surrey, Imperial Chemical Industries Ltd, Central Toxicology Laboratory (Report No. CTL/P/1592).

    Google Scholar 

  • Breckenridge, A.M., Cholerton, S., Hart, J.A.D., Park, B.K. and Scott, A.K. (1985). A study of the relationship between the pharmacokinetics and pharmacodynamics of 4-hydroxycoumar-in anticoagulants, warfarin, difenacoum, and brodifacoum in the rabbit. Br. J. Pharmacol. 84, 81–91.

    Google Scholar 

  • Brown, D. (1997). Chetwode island kiore and weka eradication project. Ecol. Manage. 5, 11–20.

    Google Scholar 

  • Buckle, A.P. and Fenn, M.G.P. (1992). Rodent control in conservation of endangered species. In J.E. Borecco and R.E. Marsh (eds) Proceedings of the 13th Vertebrate Pest Conference, pp. 36–41. Newport Beach, USA.

  • Bullard, R.W., Thompson, R.D. and Holgvin, G. (1976). Diphenadione (diphacinone) residue in tissue of cattle. J. Agric. Food Chem. 24, 261–3.

    Google Scholar 

  • Colvin, B.A., Jackson, W.B. and Hegdal, P.L. (1987). Secondary poisoning hazards associated with rodenticide use. In E.D. Magallona (ed) Proceedings of the 11th International Congress of Plant Protection, pp. 60–4, Manila, October 1987.

  • Cowan, P.E. and Tyndale-Biscoe, C.H. (1997). Australian and New Zealand mammal species considered to be pests or problems. Reprod. Fertil. Dev. 9, 27–36.

    Google Scholar 

  • Dowding, J.E., Murphy, E.C. and Veitch, C.R. (1999). Brodifacoum residues in target and non-target species following an aerial poisoning operation on Motuihe Island, Hauraki Gulf, New Zealand. N. Z. J. Ecol. 23, 207–14.

    Google Scholar 

  • Duckett, J.E. (1984). Barn owls (Tyto alba) and the ‘second generation’ rat baits utilised in oil palm plantations in Peninsula Malaysia. Planter 60, 3–11.

    Google Scholar 

  • Eason, C.T. and Spurr, E.B. (1995). Review of the toxicity and impacts of brodifacoum on non-target wildlife in New Zealand. N. Z. J. Zool. 22, 371–9.

    Google Scholar 

  • Eason, C.T., Wright, G.R. and Batcheler, D. (1996a). Anticoagulant effects and persistence of brodifacoum in possums (Trichosurus vulpecula.) N. Z. J. Agric. Res. 39, 397–400.

    Google Scholar 

  • Eason, C.T., Wright, G.R., Meikle, L. and Elder, P. (1996b). The persistence and secondary poisoning risks of sodium monofluoroacetate (1080), brodifacoum, and cholecalciferol in possums Proceedings of the 17th Vertebrate Pest Control Conference, University of California, Davis, USA, pp. 54–8.

  • Eason, C.T., Milne, L., Potts, M., Morriss, G., Wright, G.R.G. and Sutherland, O.R.W. (1999a). Secondary and tertiary poisoning risk associated with brodifacoum. N. Z. J. Ecol. 23, 219–24.

    Google Scholar 

  • Eason, C.T., Wright, G.R.G. and Gooneratne, R. (1999b). Pharmacokinetics of antipyrine, warfarin and paracetamol in the brushtail possum. J. Appl. Toxicol. 19, 157–61.

    Google Scholar 

  • Empson, R.A. and Miskelly, C.M. (1999). The risks, costs and benefits of using brodifacoum to eradicate rats from Kapiti Island, New Zealand. N. Z. J. Ecol. 23, 241–54.

    Google Scholar 

  • Fitzek, A. (1978). Pharmakokinetics of 2-pivaloylindane 1,3-Dione in dogs. Acta Pharmacol. Toxicol. 42, 81–7.

    Google Scholar 

  • Godfrey, M.E.R. (1985). Non-target and secondary poisoning hazards of ‘second generation’ anticoagulants. Acta Zool. Fenn. 173, 209–12.

    Google Scholar 

  • Gray, A., Eadsforth, C.V., Dutton, A.J. and Vaughan, J.A. (1992). Toxicity of second-generation rodenticides in barn owls. In Proceedings of the Brighton Crop Protection Conference 2, 781–6.

    Google Scholar 

  • Hadler, M.R. and Shadbolt, R.S. (1975). Novel 4-hydroxycoumarin anticoagulants active against resistant rats. Nature (Lond.) 253, 277–82.

    Google Scholar 

  • Hone, J. and Mulligan, H. (1982). Vertebrate pesticides. Science Bulletin 89, Department of Agriculture, NSW, Australia. 130 pp.

    Google Scholar 

  • Howald, G.R., Mineau., P., Elliott, J.E. and Cheng, K.M. (1999). Brodifacoum poisoning of avian scavengers during rat control on a seabird colony. Ecotoxicology 8, 431–47.

    Google Scholar 

  • Huckle, K.R. and Warburton, P.A. (1989). Studies on the fate of flocoumafen in the Japanese quail (Coturnix coturnix japonica). Xenobiotica 19, 51–62.

    Google Scholar 

  • Huckle, K.R., Hutson, D.H. and Warburton, P.A. (1988). Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration. Xenobiotica 18, 1465–79.

    Google Scholar 

  • Huckle, K.R., Hutson, D.H., Logan, C.J., Morrison, B.J. and Warburton, P.A. (1989). The fate of the rodenticide flocoumafen in the rat: Retention and elimination of a single oral dose. Pestic. Sci. 25, 297–312.

    Google Scholar 

  • Innes, J. and Barker, G. (1999). Ecological consequences of toxin use for mammalian pest control in New Zealand—an overview. N. Z. J. Ecol. 23, 111–27.

    Google Scholar 

  • Kamil, N. (1987). Kinetics of bromodialone, anticoagulant rodenticide, in the Norway rat (Rattus norvegicus). Pharmacol. Res. Commun. 19, 767–75.

    Google Scholar 

  • Laas, F.Y., Forss, D.A. and Godfrey, M.E.R. (1985). Retention of brodifacoum in sheep and excretion in faeces. N. Z. J. Agric. Res. 28, 357–9.

    Google Scholar 

  • Lechevin, J.C. and Poche, R.M. (1988). Activity of LM2219 (Difethialone), a new anticoagulant rodenticide, in commensal rodents. In A.C. Crabb, and R.E. Marsh (eds) Proceedings of the Vertebrate Pest Conference, pp. 59–63. University of California, Davis, USA.

    Google Scholar 

  • Lee, C.H. (1995). Rat control in cocoa and oil palms and the implications of toxicity on barn owls. Planter 71, 531–8.

    Google Scholar 

  • Lund, M. (1981). Hens, eggs and anticoagulants. Int. Pest Control. 5, 127–8.

    Google Scholar 

  • Mendenhall, V.M. and Pank, L.F. (1980). Secondary poisoning of owls by anticoagulant rodenticides. Wildl. Soc. Bull. 8, 311–5.

    Google Scholar 

  • Morgan, D.R., Wright, G.R., Ogilvie, S.C., Pierce, R. and Thomson, P. (1996). Assessment of the environmental impact of brodifacoum during rodent eradication operations in New Zealand. In R.M. Timm and A.C. Crabb (eds) Proceedings of the seventeenth Vertebrate Pest Control Conference, pp. 213–8. Davis, University of California.

    Google Scholar 

  • Murphy, E.C., Clapperton, B.K., Bradfield, P.M.F. and Speed, H.J. (1998). Brodifacoum residues in target and non-target animals following large-scale poison operations in New Zealand podocarp-hardwood forests. N. Z. J. Zool. 25, 307–14.

    Google Scholar 

  • Nelson, P.C. and Hickling, G.J. (1994). Pindone for rabbit control: efficacy, residue, and costs. In W.S. Halverson and A.C. Crabb (eds) Proceedings of 16th Vertebrate Pest Conference, pp. 217–9. University of California, Davis, USA.

    Google Scholar 

  • Newton, I., Wyllie, I. and Freestone, P. (1990). Rodenticides in British barn owls. Environ. Pollut. 68, 101–17.

    Google Scholar 

  • Newton, I., Wyllie, I., Gray, A. and Eadsfurth, C.V. (1994). The toxicity of the rodenticide flocoumafen to barn owls and its elimination via pellets. Pestic. Sci. 41, 187–93.

    Google Scholar 

  • Newton, I., Shore, R.F., Wyllie, I., Birks, J.D.S. and Dale, L. (1999). Empirical evidence of side-effects of rodenticides on some predatory birds and mammals. In D.P. Cowan and C.J. Feare (eds) Advances in Vertebrate Pest Management, pp. 347–67. Filander, Fürth, Germany.

    Google Scholar 

  • O'Brien, P.H., Beck, J.A. and Lukins, B.S. (1987). Residue tissue levels of warfarin and 1080 in poisoned feral pigs. Unpublished report: Working paper presented at the Australian Vertebrate Pest Control Conference.

  • Ogilvie, S.C., Pierce, R.J., Wright, G.R.G., Booth, L.H. and Eason, C.T. (1997). Brodifacoum residue analysis in water, soil, invertebrates, and birds after rat eradication on Lady Alice Island. N. Z. J. Ecol. 21, 195–7.

    Google Scholar 

  • O'Reilly, R.A., Aggeler, P.M. and Leong, L.S. (1963). Studies on the coumarin anticoagulant drugs: The pharmacodynamics of warfarin in man. J. Clin. Investig. 4, 1542–51.

    Google Scholar 

  • Parmar, G., Bratt, H., Moore, R. and Batten, P.L. (1987). Evidence for a common binding site in vivo for the retention of anticoagulants in rat liver. Hum. Toxicol. 6, 431–2.

    Google Scholar 

  • Pierce, R. and Moorehouse, R. (1994). Survival of kaka following aerial poisoning with Talon on Whatupuke Island. Conservation Science Advisory Notes No. 87. Wellington, Department of Conservation. 5 pp.

    Google Scholar 

  • Pyrola, K. (1968). Sex differences in the clotting factor response to warfarin and of warfarin metabolism in the rat. Ann. Med. Exp. Biol. Fenn. 46, 23–34.

    Google Scholar 

  • Robben, J.H., Kujpers, E.A. and Mout, H.C. (1998). Plasma superwarfarin levels and vitamin K1 treatment in dogs with anticoagulant rodenticide poisoning. Vet. Q. 20, 24–7.

    Google Scholar 

  • Roberston, H.A., Colbourne, R.M. and Nieuwland, F. (1993). Survival of little spotted kiwi and other forest birds exposed to brodifacoum rat poison on Red Mercury Island. Notornis 40, 253–62.

    Google Scholar 

  • Robertson, H.A., Colbourne, R.M., Graham, P.J., Miller, P.J. and Pierce, R.J. (1999). Survival of brown kiwi (Apteryx mantelli) exposed to brodifacoum poison in Northland, New Zealand. N. Z. J. Ecol. 23, 225–31.

    Google Scholar 

  • Savarie, P.J.D., Hayes, R.T., McBride, R.T. and Roberts, J.D. (1979). Efficacy and safety of diphacinone as a predacide. In E.E. Kenaga (ed) Avian and mammalian wildlife toxicology, pp. 69–79. American Society for Testing and Materials, Special Technical Publication 693.

  • Shore, R.F., Birks, J.D.S. and Freestone, P. (1999). Exposure of non-target vertebrates to second-generation rodenticides in Britain, with particular reference to the polecat Mustela putarius. N. Z. J. Ecol. 23, 199–206.

    Google Scholar 

  • Stephenson, B.M., Minot, E.O. and Armstrong, D.P. (1999). Fate of moreporks (Ninox novaeseelandiae) during a pest control operation on Mokoia Island, Lake Rotorua, North Island, New Zealand. N. Z. J. Ecol. 23, 233–40.

    Google Scholar 

  • Stone, W.B., Okoniewski, J.C. and Stedlin, J.R. (1999). Poisoning of wildlife with anticoagulant rodenticides in New York. J. Wildl. Dis. 35, 187–93.

    Google Scholar 

  • Taylor, D.P. (1984). The identification and detection of the rats in New Zealand and the eradication of ship rats on Tawhitinui Island. Dissertation for Diploma in Parks and Recreation, Lincoln College, Canterbury unpublished, 73 pp.

  • Taylor, R.H. and Thomas, B.W. (1989). Eradication of Norway rats (Rattus norvegicus) from Hawea Island, Fiordland, using brodifacoum. N. Z. J. Ecol. 12, 23–32.

    Google Scholar 

  • Taylor, R.H. and Thomas, B.W. (1993). Rats eradicated from rugged Breaksea Island (170 ha), Fiordland, New Zealand. Biol. Conserv. 65, 191–8.

    Google Scholar 

  • Towns, D., McFadden, I. and Lovegrove, T. (1993). Offshore islands co-operative conservation project with ICI Crop Care Division: Phase one (Stanley Island). Wellington, Department of Conservation, Science and Research Internal Report No. 138. 24 pp.

    Google Scholar 

  • Towns, D., McFadden, I., Thomson, P., Robertson, H. and Colbourne, R. (1994). Offshore islands co-operative conservation project with ICI Crop Care Division: Phase two (Red Mercury Island). Wellington, Department of Conservation, Science and Research Internal Report No. 142. 12 pp.

    Google Scholar 

  • Townsend, M.G., Fletcher, M.R., Odam, E.M. and Stanley, P.I. (1981). An assessment of the secondary poisoning hazard of warfarin to tawny owls. J. Wildl. Manage. 45, 242–8.

    Google Scholar 

  • Turbott, E.G. (1990). Checklist of the birds of New Zealand. Wellington, Ornithological Society. 247 pp.

    Google Scholar 

  • Veenstra, G.E., Owen, D.E. and Huckle, K.R. (1991). Metabolic and toxicological studies on the anticoagulant rodenticide flocoumafen. Arch. Toxicol. 14(Suppl.), 160–5.

    Google Scholar 

  • Veitch, C.R. (1994). Habitat repair: A necessary prerequisite to translocation of threatened birds. In M. Serena (ed) Reintroduction biology of Australian and New Zealand fauna, pp. 97–104. Surrey Beatty, Chipping Norton NSW, Australia.

    Google Scholar 

  • Walker, K. and Elliott, G. (1997). Effect of the poison brodifacoum on non-target birds on the Chetwode Islands. Ecol. Manage. 5, 21–7.

    Google Scholar 

  • Weitzel, J.N., Sadowski, J.A., Furie, B.C., Moroose, R., Kim, H., Mount, M.E., Murphy, M.J. and Furie, B. (1990). Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: Clinical and metabolic studies of three cases. Blood 76, 2555–9.

    Google Scholar 

  • Williams, J.M., Bell, J., Ross, W.D. and Broad, T.M. (1986). Rabbit (Oryctolagus cuniculus) control with a single application of 50 ppm brodifacoum cereal baits. N. Z. J. Ecol. 9, 123–36.

    Google Scholar 

  • Woody, B.J., Murphy, M.J., Ray, A.C. and Green, R.A. (1992). Coagulopathic effects and therapy of brodifacoum toxicosis in dogs. J. Vet. Intern. Med. 6, 23–8.

    Google Scholar 

  • World Health Organisation, (1995). Anticoagulant rodenticides. Environ. Health Criter. 175, 121 pp.

  • Worthing, C.R. and Hance, R.J. (1991). The pesticide manual. A world compendium 9th edition. The British Crop Protection Council. 1141 pp.

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Authors and Affiliations

  1. CENTOX (Centre for Environmental Toxicology), Landcare Research, P.O. Box 69, Lincoln, 8152, New Zealand

    Charles T. Eason, Geoffrey R.G. Wright & Eric B. Spurr

  2. Department of Conservation, Private Bag 4715, Christchurch, 8001, New Zealand

    Elaine C. Murphy

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  1. Charles T. Eason
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  2. Elaine C. Murphy
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Eason, C.T., Murphy, E.C., Wright, G.R. et al. Assessment of Risks of Brodifacoum to Non-target Birds and Mammals in New Zealand. Ecotoxicology 11, 35–48 (2002). https://doi.org/10.1023/A:1013793029831

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