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Local Regulation of Proliferation and Differentiation of Hemopoietic Precursors during Experimental Neuroses

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Abstract

Intensive formation of hemopoietic islets and secretion of humoral hemopoiesis stimulators by cells of the hemopoietic microenvironment underlie activation of proliferation and differentiation of erythroid and granulocyte-macrophage precursors in conflict situation. Stimulation of division and maturation of committed granulomonocytic precursors during paradoxical sleep deprivation is primarily related to intensive secretion of humoral factors by hemopoietic elements. The inhibition of proliferative activity and differentiation of erythroid precursors is associated with the impaired formation of erythroid hemopoietic islets and suppressed secretion of humoral erythropoiesis stimulators by nonadherent fractions of the hemopoietic microenvironment.

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Authors and Affiliations

  1. Laboratory of Pathological Physiology and Experimental Therapy, Group of Psychopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk

    A. M. Dygai, E. G. Skurikhin, N. V. Provalova & N. I. Suslov

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  1. A. M. Dygai
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  2. E. G. Skurikhin
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  3. N. V. Provalova
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  4. N. I. Suslov
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Dygai, A.M., Skurikhin, E.G., Provalova, N.V. et al. Local Regulation of Proliferation and Differentiation of Hemopoietic Precursors during Experimental Neuroses. Bulletin of Experimental Biology and Medicine 133, 12–16 (2002). https://doi.org/10.1023/A:1015179721834

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  • DOI: https://doi.org/10.1023/A:1015179721834

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