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Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells

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Abstract

Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc-strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time.

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Authors and Affiliations

  1. Cardiological Research and Production Association, Ministry of Health of the Russian Federation, ul. Tret'ya Cherepkovskaya 15a, Moscow, 121552, Russia

    M. V. Sidorova, A. S. Molokoedov, T. I. Aref'eva, N. B. Kukhtina, T. L. Krasnikova, Zh. D. Bespalova & V. N. Bushuev

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  1. M. V. Sidorova
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  2. A. S. Molokoedov
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  3. T. I. Aref'eva
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  4. N. B. Kukhtina
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  5. T. L. Krasnikova
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  6. Zh. D. Bespalova
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  7. V. N. Bushuev
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Sidorova, M.V., Molokoedov, A.S., Aref'eva, T.I. et al. Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells. Russian Journal of Bioorganic Chemistry 30, 523–533 (2004). https://doi.org/10.1023/B:RUBI.0000049768.98894.f5

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  • DOI: https://doi.org/10.1023/B:RUBI.0000049768.98894.f5

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