Abstract
The effects of prolonged (42 day) consumption of deuterium-depleted water by rats on the functional state of their central nervous system under normal conditions and under conditions of normobaric hypercapnic hypoxia have been studied. The consumption of deuterium-depleted water both under normal conditions and after exposure to oxidative stress contributed to a significant reduction in emotional anxiety in animals. Prolonged consumption of deuterium-depleted water before experimental hypoxia (amnesic factor) helped animals to maintain their ability to learn and memory at the control level, i.e., it exerted a pronounced protective antiamnesic effect. Under normal conditions, deuterium-depleted water does not affect the learning ability of animals.
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Funding
This work was supported by the Russian Foundation for Basic Research, project 19-44-233005, and State Budgeted Project АААА-A19-119040390083-6 for the Southern Scientific Center of the RAS.
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Statement on the Welfare of Animals
All manipulations with humans met the principles of humanity in accordance with the Guidelines for Conducting Works with Experimental Animals, Executive Order No. 708n of the Ministry of Health and Social Development of the Russian Federation “On Approval of Good Laboratory Practice” of August 23, 2010.
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Translated by V. Gulevich
Abbreviations: CNS, central nervous system, DDW, deuterium-depleted water; EPM, elevated plus maze; ROS, reactive oxygen species.
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Kozin, S.V., Kravtsov, A.A., Zlischeva, E.I. et al. The Influence of a Deuterium Depleted Drinking Diet on the Functional State of the Central Nervous System of Animals in Hypoxia. BIOPHYSICS 65, 1017–1022 (2020). https://doi.org/10.1134/S0006350920060093
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DOI: https://doi.org/10.1134/S0006350920060093