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Effect of tumor necrosis factor-related apoptosis-inducing ligand on developing human oligodendrocytes in culture

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Abstract

Accumulating evidence suggests that proinflammatory cytokines play an important role in white matter injury in preterm infants, a condition in which oligodendrocyte (OL) progenitor cells are preferentially injured. We investigated the role of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its death (TRAIL-R1, TRAIL-R2) and decoy (TRAIL-R3, TRAIL-R4) receptors in periventricular white matter injury (PWMI). We hypothesized that the maturation-dependent vulnerability of OLs to TRAIL is due to the differential TRAIL receptor expression. We previously investigated TRAIL/TRAIL receptor expression levels in rat OLs in vivo in the context of PWMI. We found that during different developmental stages, human OLs differentially express TRAIL receptors; and there is a progressive loss of sensitivity to TRAIL as OLs proceed through the maturation process. Our results show that both TRAIL-R1 and -R2 are highly expressed on human OL progenitors and pre-OLs, while TRAIL-R3 and TRAIL-R4 are mainly expressed on immature and mature human OLs. Our results suggest that TRAIL-R1 and TRAIL-R2 might mediate the death signal in human OL precursor cells and pre-OLs.

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Authors and Affiliations

  1. Department of Neonatology, Children’s hospital of Fudan University, 399, Wanyuan Road, Shanghai, 201102, China

    M. -L. Xiao & C. Chen

  2. Department of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201102, China

    J. -Q. Liu

Authors
  1. M. -L. Xiao
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  2. J. -Q. Liu
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  3. C. Chen
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Correspondence to M. -L. Xiao.

Additional information

Published in Russianin Molekulyarnaya Biologiya, 2014, Vol. 48, No. 6, pp. 963–969.

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Xiao, M.L., Liu, J.Q. & Chen, C. Effect of tumor necrosis factor-related apoptosis-inducing ligand on developing human oligodendrocytes in culture. Mol Biol 48, 845–851 (2014). https://doi.org/10.1134/S002689331406020X

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  • DOI: https://doi.org/10.1134/S002689331406020X

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