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Methods of Determination of Antibiotic Residues in Honey

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Abstract

Monitoring antibiotics residues in honey and honey products helps to assess the potential risk of these products to human health. These data provide an insight in the extent of antibiotic treatment that has been used during the beekeeping and enable the evaluation of potential environment pollution with antibiotic residues. This article offers an overview of methods for identification and determination of different antibiotics potentially present in honey, as well as of maximum residue limits for antibiotics in bee products, in particular honey. It is important to stress the importance of strict monitoring system and validation of analytical methods that will enable an accurate, precise and reliable determination of acceptable minimal concentrations of pollutants in honey.

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References

  1. Al-Waili, N., Salom, K., Al-Ghamdi, A., and Ansari, M.J., Sci. World J., 2012, 930849.

    Google Scholar 

  2. Chen, L., Mehta, A., Berenbaum, M., Zangerl, A.R., and Engeseth, N.J., J. Agric. Food Chem., 2000, vol. 48, no. 10, p. 4997.

    Article  CAS  Google Scholar 

  3. Mundo, M.A., Padilla-Zakour, O.I., and Worobo, R.W., Int. J. Food Microbiol., 2004, vol. 97, no. 1, p.1.

    Article  CAS  Google Scholar 

  4. Kelly, S., Heaton, K., and Hoogewerff, J., Trends Food Sci. Technol., 2005, vol. 16, no. 12, p.555.

    Article  CAS  Google Scholar 

  5. Prica, N., Živkov-Baloš, M., Jakšic, S., Mihaljev, Ž., Kartalovic, B., Babic, J., and Savic, S., Arch. Vet. Med., 2014, vol. 7, no. 2, p.99.

    Google Scholar 

  6. Bogdanov, S., Apidologie, 2006, vol. 37, no. 1, p.1.

    Article  CAS  Google Scholar 

  7. Alippi, A.M., López, A.C., Reynaldi, F.J., Grasso, D.H., and Aguilar, O.M., Vet. Microbiol., 2007, vol. 125, nos. 3–4, p.290.

    Article  CAS  Google Scholar 

  8. Reybroeck, W., Ooghe, S., Brabander, H.D., and Daeseleire, E., J. Agric. Food Chem., 2007, vol. 55, no. 21, p. 8359.

    Article  CAS  Google Scholar 

  9. Bogdanov, S., Apiacta, 2003, vol. 38, p.190.

    Google Scholar 

  10. Wangfuengkanagul, N., Siangproh, W., and Chailapakul, O., Talanta, 2004, vol. 64, no. 5, p. 1183.

    Article  CAS  Google Scholar 

  11. World Health Organization. Antimicrobial resistance: No action today, no cure tomorrow. http://www. who.int/world-health-day/2011/en/index.html. Accessed September 7, 2017.

  12. European Commission, Council Regulation 2377/90, Off. J. Eur. Commun., 1990, L224.

  13. European Commission, Council Regulation 470/2009, Off. J. Eur. Commun., 2009, L151.

  14. European Commission, Commission Regulation 37/2010, Off. J. Eur. Commun., 2010, L15.

  15. Gunes, M.E., Gunes, N., and Cibik, R., Bulg. J. Agric. Sci., 2009, vol. 15, no. 2, p.163.

    Google Scholar 

  16. European Commission, Commission Decision amending Decision 2002/657/EC, Off. J. Eur. Commun., 2003, L71.

  17. Code of Federal Regulations, Title 21: Food and Drugs, PART 556—Tolerances for residues of new animal drugs in food. www.ecfr.gov/cgi-bin/retrieveECFR? gp=1&SID=fedfe8b9e21875e35e8462a41527a1-f3&ty =HTML&h=L&r=PART&n=21y6.0.1.1.17#se21.6.55 6_1720. Accessed September 7, 2017.

  18. Peres, G.T., Rath, S., and Reyes Reyes, F.G., Food Control, 2010, vol. 21, p.620.

    Article  CAS  Google Scholar 

  19. Jeon, M. and Paeng, I.R., Anal. Chim. Acta, 2008, vol. 626, p.180.

    Article  CAS  Google Scholar 

  20. Johnson, S. and Jadon, N., Antibiotic Residues in Honey, Centre for Science and Environmentindia Habitat, New Delhi, 2010. http://www.cseindia.org/userfiles/ Antiboitics_Honey.pdf. Accessed September 7, 2017.

    Google Scholar 

  21. Codex Alimentarius Commission (2001). Revised Codex Standard for Honey, Codex STAN 12-1981, Rev. 1 (1987), Rev. 2 (2001).

  22. Salter, B., Apiacta, 2003, vol. 38, p.198.

    Google Scholar 

  23. Heering, W., Usleber, E., Dietrich, R., and Märtlbauer, E., Analyst, 1998, vol. 123, no. 12, p. 2759.

    Article  CAS  Google Scholar 

  24. Kaufmann, A., Roth, S., Ryser, B., and Widmer, M., J. AOAC Int., 2001, vol. 85, p.853.

    Google Scholar 

  25. Barganska, Z., Namiesnik, J., and Slebioda, M., TrAC, Trends Anal. Chem., 2011, vol. 30, no. 7, p. 1035.

    Article  CAS  Google Scholar 

  26. Mulalic, J., Kozacinski, L., Benussi Skukan, A., Filipovic, I., and Runje, M., Meso, 2006, vol. 8, no. 1, p.37.

    Google Scholar 

  27. R-Biopharm, Germany. www.r-biopharm.com. Accessed September 7, 2017.

  28. Onal, A., Food Chem., 2011, vol. 127, p.197.

    Article  Google Scholar 

  29. Udalova, A.Y., Dmitrienko, S.G., and Apyari, V.V., J. Anal. Chem., 2015, vol. 70, p.577.

    Google Scholar 

  30. Rissato, S.R., Galhiane, M.S., de Almeida, M.V., Gerenutti, M., and Apon, B.M., Food Chem., 2007, vol. 101, no. 4, p. 1719.

    Article  CAS  Google Scholar 

  31. Anastassiades, M., Lehotay, S.J., Stajnbaher, D., and Schenck, F.J., J. AOAC Int., 2003, vol. 86, no. 2, p.412.

    CAS  Google Scholar 

  32. Alfredsson, G., Branzell, C., Granelli, K., and Lundstrom, A., Anal. Chim. Acta, 2005, vol. 529, p.47.

    Article  CAS  Google Scholar 

  33. Peters, R.J.B., Stolker, A.A.M., Mol, J.G.J., Lommen, A., Lyris, E., Angelis, Y., Vonaparti, A., Stamou, M., Georgakopoulos, C., and Nielen, M.W.F., TrAC, Trends Anal. Chem., 2010, vol. 29, no. 11, p. 1250.

    Article  CAS  Google Scholar 

  34. Pena, A., Pelantova, N., Lino, C.M., Silveira, M.I.N., and Solich, P., J. Agric. Food Chem., 2005, vol. 53, no. 10, p. 3784.

    Article  CAS  Google Scholar 

  35. Fujita, K., Ito, H., Ishihara, M., Inukai, S., Tanaka, H., and Taniguchi, M., J. Food Hyg. Soc. Jpn., 2008, vol. 49, no. 3, p.196.

    Article  CAS  Google Scholar 

  36. Sporns, P., Kwan, S., and Roth, L.A., J. Food Prot., 1986, vol. 49, p.383.

    Article  CAS  Google Scholar 

  37. Martel, A.-C., Zeggane, S., Drajnudel, P., Faucon, J.-P., and Aubert, M., Food Addit. Contam., 2006, vol. 23, no. 3, p.265.

    Article  CAS  Google Scholar 

  38. Vinas, P., Balsalobre, N., Lopez-Erroz, C., and Hernandez-Cordoba, M., J. Chromatogr. A, 2004, vol. 1022, p.125.

    Article  CAS  Google Scholar 

  39. Hakuta, T., Shinzawa, H., and Ozaki, Y., Anal. Sci., 2009, vol. 25, p. 1149.

    Article  CAS  Google Scholar 

  40. Anderson, C.R., Rupp, H.S., and Wu, W.-H., J. Chromatogr. A, 2005, vol. 1075, p.23.

    Article  CAS  Google Scholar 

  41. Schwaiger, I. and Schuch, R., Dtsch. Lebensm.-Rundsch., 2000, vol. 96, p.93.

    Google Scholar 

  42. Diserens, J.M. and Savoy-Perroud, M.C., Determination of sulfonamide residues in honey, Report of the NRC Nestle Research Center, Switzerland, 2002.

    Google Scholar 

  43. Pang, G.F., Cao, Y.Z., Fan, C.L., Zhang, J.J., Li, X.M., Li, Z.Y., and Jia, G.Q., Anal. Bioanal. Chem., 2003, vol. 376, p.534.

    Article  CAS  Google Scholar 

  44. Galina, A., Benetti, C., Biancotto, G., Baggio, A., Manzinello, C., Dainese, N., and Muntinelli, F., Apiacta, 2005, vol. 40, p.45.

    Google Scholar 

  45. Bernal, J., Nozal, M.J., Jiménez, J.J., Martín, M.T., and Sanz, E., J. Chromatogr. A, 2009, vol. 1216, no. 43, p. 7275.

    Article  CAS  Google Scholar 

  46. Bonta, V. Al., Marghitas, L., Dezmirean, D., and Bobis, O., Bull. Univ. Agric. Sci. Vet. Med., Anim. Sci. Biotechnol., 2009, vol. 66, nos. 1–2, p.237.

    CAS  Google Scholar 

  47. Posyniak, A., Sniegocki, T., and Zmudzki, J., Bull. Vet. Inst. Pulawy, 2002, vol. 46, p.111.

    Google Scholar 

  48. Posyniak, A., Jazdzewski, K., Pietruszka, K., Mitrowska, K., and Gajda, A., Bull. Vet. Inst. Pulawy, 2008, vol. 52, p.87.

    Google Scholar 

  49. Zotou, A. and Vasiliadou, C., Chromatographia, 2006, vol. 64, p.307.

    Article  CAS  Google Scholar 

  50. Tsai, W.H., Chuang, H.Y., Chen, H.H., Wu, Y.W., Cheng, S.H., and Huang, T.C., J. Chromatogr. A, 2010, vol. 1217, p. 7812.

    Article  CAS  Google Scholar 

  51. Shen, H. and Jiang, H., Anal. Chim. Acta, 2005, vol. 535, p.33.

    Article  CAS  Google Scholar 

  52. Pan, C., Zhang, H., Chen, S., Xu, Y., and Jiang, S., Acta Chromatogr., 2006, vol. 17, p.320.

    CAS  Google Scholar 

  53. Klementz, D. and Pestemer, W., Nachrichtenbl. Dtsch. Pflanzenschutzdienstes (Braunschweig, Ger.), 1996, vol. 48, p.280.

    CAS  Google Scholar 

  54. Edder, P., Cominoli, A., and Corvi, C., Mitt. Geb. Lebensmittelunters. Hyg., 1998, vol. 89, p.369.

    CAS  Google Scholar 

  55. Edder, P., Cominoli, A., and Corvi, C., J. Chromatogr. A, 1999, vol. 830, p.345.

    Article  CAS  Google Scholar 

  56. Viñas, P., Balsalobre, N., and Hernández-Córdoba, M., Talanta, 2007, vol. 72, p.808.

    Article  Google Scholar 

  57. Draiaia, R., Chefrour, A., Dainese, N., Borin, A., Manzinello, C., Gallina, A., and Mutinelli, F., Afr. J. Biotechnol., 2015, vol. 14, no. 14, p. 1242.

    Article  CAS  Google Scholar 

  58. Zimmermann, S., Gierschner, K.H., and Vorwohl, G., Dtsch. Lebensm.-Rundsch., 1993, vol. 89, p.341.

    CAS  Google Scholar 

  59. European Commission, Commission Decision 2002/657/EC implementing Council Directive 96/23/EC, Off. J. Eur. Commun., 2002, L221.

  60. Nakazawa, H., Ino, S., Kato, K., Watanabe, T., Ito, Y., and Oka, H., J. Chromatogr. B: Biomed. Sci. Appl., 1999, vol. 732, no. 1, p.55.

    Article  CAS  Google Scholar 

  61. Debayle, D., Dessalces, G., and Grenier-Loustalot, M.F., Anal. Bioanal. Chem., 2008, vol. 391, p. 1011.

    Article  CAS  Google Scholar 

  62. Hammel, Y.A., Mohamed, R., Gremaud, E., LeBreton, M.H., and Guy, P.A., J. Chromatogr. A, 2008, vol. 1177, p.58.

    Article  CAS  Google Scholar 

  63. De Brabander, H.F., Noppe, H., Verheyden, K., Bussche, J.V., Wille, K., Okerman, L., Vanhaecke, L., Reybroeck, W., Ooghe, S., and Croubels, S., J. Chromatogr. A, 2009, vol. 1216, no. 46, p. 7964.

    Article  Google Scholar 

  64. Lehotay, S.J., Mastovska, K., Amirav, A., Fialkov, A.B., Alon, T., Martos, P.A., de Kok, A., and Fernandez-Alba, A.R., TrAC, Trends Anal. Chem., 2008, vol. 27, no. 11, p. 1070.

    Article  CAS  Google Scholar 

  65. Kujawski, M.W. and Namiesnik, J., TrAC, Trends Anal. Chem., 2008, vol. 27, p.785.

    Article  CAS  Google Scholar 

  66. Martínez-Vidal, J.L., Aguilera-Luiz, M.M., Romero-González, R., and Garrido-Frenich, A., J. Agric. Food Chem., 2009, vol. 57, p. 1760.

    Article  Google Scholar 

  67. Bie, M., Li, R., Chai, T., Dai, S., Zhao, H., Yang, S., and Qiu, J., Adv. Appl. Sci. Res., 2012, vol. 3, no. 1, p.462.

    CAS  Google Scholar 

  68. Krivohlavek, A., Žuntar, I., Ivešic, M., Mandic Andacic, I., and Šikic, S., Psychiatr. Danubina, 2014, vol. 26, no. 3, p.537.

    CAS  Google Scholar 

  69. Mokh, S., Jaber, F., Kouzayha, A., Budzinski, H., and Al Iskandarani, M., Am. J. Anal. Chem., 2014, vol. 5, p.982.

    Article  Google Scholar 

  70. Dubreil-Chéneau, E., Pirotais, Y., Verdon, E., and Hurtaud-Pessel, D., J. Chromatogr. A, 2014, vol. 1339, p.128.

    Article  Google Scholar 

  71. Preu, M., Guyot, D., and Petz, M., J. Chromatogr. A, 1998, vol. 818, p. 95.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Scientific Veterinary Institute “Novi Sad,”, Novi Sad, 21000, Serbia

    S. M. Jakšić, R. D. Ratajac, N. B. Prica, J. B. Apić, D. B. Ljubojević, M. Z. Žekić Stošić & M. M. Živkov Baloš

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  1. S. M. Jakšić
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  2. R. D. Ratajac
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  3. N. B. Prica
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  4. J. B. Apić
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Jakšić, S.M., Ratajac, R.D., Prica, N.B. et al. Methods of Determination of Antibiotic Residues in Honey. J Anal Chem 73, 317–324 (2018). https://doi.org/10.1134/S1061934818040044

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