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Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action

  • Animal and Human Physiology
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Abstract

The effects of the adrenocorticotropic hormone (ACTH(4–10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the back-ground of cholecystokinin-tetrapeptide (CCK-4) action. Semax was injected intranasally in doses of 50 and 500 μg/kg 15 min before the testing. CCK-4 was administered intraperitoneally in a dose of 400 μg/kg 40 min before the testing. The level of anxiety was estimated in the elevated plus-maze test, and the degree of depression, in the forced swimming test. Semax administration did not influence the emotional state of animals in the normal state. The CCK-4 injection led to an increase in anxiety and depression in rats. Semax normalized the animal behavior disturbed by the CCK-4 administration, which attests to its anxiolytic and antidepressant effects at elevated levels of anxiety and depression.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    N. G. Levitskaya, E. A. Sebentsova, L. A. Andreeva & N. F. Myasoedov

  2. Faculty of Biology, Moscow State University, Moscow, Russia

    D. A. Vilenskii & A. A. Kamensky

Authors
  1. N. G. Levitskaya
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  2. D. A. Vilenskii
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  3. E. A. Sebentsova
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  4. L. A. Andreeva
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  5. A. A. Kamensky
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  6. N. F. Myasoedov
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Correspondence to N. G. Levitskaya.

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Original Russian Text © N.G. Levitskaya, D.A. Vilenskii, E.A. Sebentsova, L.A. Andreeva, A.A. Kamensky, N.F. Myasoedov, 2010, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2010, No. 2, pp. 231–237.

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Levitskaya, N.G., Vilenskii, D.A., Sebentsova, E.A. et al. Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action. Biol Bull Russ Acad Sci 37, 186–192 (2010). https://doi.org/10.1134/S1062359010020147

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  • DOI: https://doi.org/10.1134/S1062359010020147

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