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Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections

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Abstract

An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5–8 min with reasonable purity in 80–90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.

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Authors and Affiliations

  1. Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur, India

    Gajanand Sharma & Preeti Bansal

  2. Department of Biotechnology and Food Science, Jayoti Vidyapeeth Women’s University, Jaipur, India

    Richa Sharma

  3. Department of Botany, University of Rajasthan, Jaipur, India

    Meenakshi Sharma

  4. Anshu Dandia, Centre of Advanced Studies, Department of Chemistry, University of Rajasthan, Rajasthan, India

    Anshu Dandia

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  1. Gajanand Sharma
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  2. Richa Sharma
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  3. Meenakshi Sharma
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  4. Anshu Dandia
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  5. Preeti Bansal
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Correspondence to Gajanand Sharma.

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Sharma, G., Sharma, R., Sharma, M. et al. Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections. Russ J Bioorg Chem 39, 318–328 (2013). https://doi.org/10.1134/S106816201303014X

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  • DOI: https://doi.org/10.1134/S106816201303014X

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