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Current Approaches to the Search of Anxiolytic Drugs

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Abstract—

This article presents a review of studies of new pharmacological substances in the aspect of their anxiolytic activity. These substances are derivatives of various chemical classes. The variety of synthesized substances described in this article is a combination of the most interesting and promising projects at the moment. According to the current trend, a further detailed preclinical study of chemical compounds with a multitarget mode of action is an extremely relevant issue for researchers in the areas of pharmacology and medicine.

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Funding

The study was carried out with the financial support of the Russian Foundation for Basic Research (project No. 20-015-00164).

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Authors and Affiliations

  1. Volgograd State Medical University, Department of Pharmacology and Bioinformatics, 400131, Volgograd, Russia

    D. V. Maltsev, A. A. Spasov, M. V. Miroshnikov & M. O. Skripka

  2. Volgograd Medical Scientific Center, Laboratory of Experimental Pharmacology, 400131, Volgograd, Russia

    D. V. Maltsev & A. A. Spasov

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  1. D. V. Maltsev
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  2. A. A. Spasov
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  3. M. V. Miroshnikov
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Correspondence to D. V. Maltsev.

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Translated by M. Novikova

Abbreviations: GABA, γ-aminobutiric acid; MAO, monoamine oxidase; NAM, negative allosteric modulator; PAM, positive allosteric modulator; PTSD, post-traumatic stress disorder; GAT, γ-aminobutiric acid transporter; GPCR, G-protein-coupled receptor; 5-HT, 5-hydroxytryptamine; mGluRs, metabotropic glutamate receptors; TRPC, transient receptor potential cation channels; TSPO, translocator protein.

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Maltsev, D.V., Spasov, A.A., Miroshnikov, M.V. et al. Current Approaches to the Search of Anxiolytic Drugs. Russ J Bioorg Chem 47, 622–652 (2021). https://doi.org/10.1134/S1068162021030122

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