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Pyrazine Derivatives—Versatile Scaffold

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Abstract

Pyrazines are important class of pharmacophores because of their versatility in pharmacological activity. Pyrazines are among the most widely known heterocyclic compounds those can be isolated from natural sources or produced synthetically. Many substituted pyrazines are produced naturally and are widely distributed in plants, animals, including marine organisms. These heterocyclic analogs have been proven important scaffold in perfumeries, food industries and pharmaceuticals. Due to diverse biological activities of pyrazine-based drugs, a rise in investigations of pyrazine containing candidates has been observed. In recent past numerous advancement has been taken place to explore their synthetic pathways and biological activities. This review focuses on biosynthesis of different pyrazine derivatives and their various biological activities.

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ACKNOWLEDGMENTS

We are grateful to Dr. P.A. Inamdar, the President of MCE Society, Pune for providing the lab facilities.

Funding

We are thankful to the Department of Science and Technology, Govt. of India for providing financial assistance under DST-FIST (0 Level) to Abeda Inamdar Senior College, Pune vide letter number SR/FST/COLLEGE-277/2018 dated 20th December 2018.

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Authors and Affiliations

  1. MCE Society’s Abeda Inamdar Senior College, Azam Campus, Pune, 411001, India

    N. Tambat, S. K. Mulani, S. B. Shaikh & K. Ahmed

  2. Advanced Scientific Research Laboratory, Department of Chemistry, Abeda Inamdar Senior College, Azam Campus, Pune, 411001, India

    N. Tambat, S. K. Mulani, S. B. Shaikh & K. Ahmed

  3. Interim Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar

    A. Ahmad

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Tambat, N., Mulani, S.K., Ahmad, A. et al. Pyrazine Derivatives—Versatile Scaffold. Russ J Bioorg Chem 48, 865–895 (2022). https://doi.org/10.1134/S1068162022050259

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