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Synthesis and Antimicrobial Activity of Methyl (2Z)-4-Aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates and Their Silver Salts

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Abstract

A series of new methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)-sulfamoyl]phenylamino}-4-oxobut-2-enoates was synthesized by the reaction of methyl esters of aroylpyruvic acids with 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in a mixture of acetic acid–ethanol (1 : 1). The obtained 4-oxobut-2-enoates reacted with silver nitrate in ethanol–DMF (2 : 1) to form their silver salts. The antimicrobial activity of the compounds was studied.

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REFERENCES

  1. Mashkovaskii, M.D., Lekarstvennye sredstva (Drugs), Moscow: Novaya Volna, 2012.

  2. Gein, V.L., Bobrovskaya, O.V., and Sitnikova, A.A., Russ. J. Gen. Chem., 2014, vol. 84, no. 4, p. 629. https://doi.org/10.1134/S1070363214040045

    Article  CAS  Google Scholar 

  3. Gein, V.L., Bobrovskaya, O.V., Kovtonogova, I.V., and Novikova, V.V., Russ. J. Gen. Chem., 2015, vol. 85, no. 4, p. 833. https://doi.org/10.1134/S1070363215040106

    Article  CAS  Google Scholar 

  4. Gein, V.L., Bobrovskaya, O.V., Kovtonogova, I.V., Belonogova, V.D., Danilov, Yu.L., Nasakin, O.E., and Kazantseva, M.I., Russ. J. Org. Chem., 2016, vol. 52, no. 12, p. 1764. https://doi.org/10.1134/S1070428016120083

    Article  CAS  Google Scholar 

  5. Gein, V.L., Bobrovskaya, O.V., Kovtonogova, I.V., Seliverstov, G.V., Russkih, A.A., Belonogova, V.D., Anisimova, A.G., and Yagontseva, T.A.,Butlerov. Commun., 2016, vol. 48, no. 12, p. 26.

    Google Scholar 

  6. Gein, V.L., Bobrovskaya, O.V., and Dmitriev, M.V., Russ. J. Org. Chem., 2017, vol. 53, no. 6, p. 898. https://doi.org/10.1134/S1070428017060148

    Article  CAS  Google Scholar 

  7. Gein, V.L., Bobrovskaya, O.V., and Gein, L.F., Russ. J. Org. Chem., 2014, vol. 50, no. 11, p. 1692. https://doi.org/10.1134/S1070428014110268

    Article  CAS  Google Scholar 

  8. Gein, V.L., Bobrovskaya, O.V., Dmitriev, M.V., Makhmudov, R.R., and Belonogova, V.D., Russ. J. Gen. Chem., 2018, vol. 88, no. 6, p. 1095. https://doi.org/10.1134/S1070363218060087

    Article  CAS  Google Scholar 

  9. Gein, V.L., Bobrovskaya, O.V., Russkikh, A.A., Dmitriev, M.V., and Yankin, A.N., Russ. J. Org. Chem., 2019, vol. 55, no. 5, p. 602. https://doi.org/10.1134/S107042801905004X

    Article  CAS  Google Scholar 

  10. Bobrovskaya, O.V., Gein, V.L., Seliverstov, G.V., Chashchina, S.V., and Dmitriev, M.V., Russ. J. Gen. Chem., 2017, vol. 87, no. 12, p. 2776. https://doi.org/10.1134/S1070363217120040

    Article  CAS  Google Scholar 

  11. Gein, V.L., Bobrovskaya, O.V., Russkikh, A.A., Novikova, V.V., Gein, O.N., Karpenko, Yu.N., Chashchina, S.V., Dmitriev, M.V., and Yankin, A.N.,Russ. J. Gen. Chem., 2019, vol. 89, no. 4, p. 680. https://doi.org/10.1134/S1070363219040078

    Article  CAS  Google Scholar 

  12. Gein, V.L., Bobrovskaya, O.V., Seliverstov, G.V., Novikova, V.V., and Makhmudov, R.R., RF Patent 2698328, 2019.

  13. Cordeiro, R.A., Teixeira, C.E.C., Brilhante, R.S.N., CasteloBranco, D.S.C.M., Paiva, M.A.N., Leite, J.J.G., Lima, D.T., Monteiro, A.J., Sidrim, J.J.C., and Rocha, M.F.G., Med. Mycology, 2013, vol. 51, no. 1, p. 53. https://doi.org/10.3109/13693786.2012.692489

    Article  CAS  Google Scholar 

  14. Rukovodstvo po provedeniyu doklinicheskikh issledovanii lekarstvennykh sredstv (Preclinical Drug Research Guide), Mironov, A.N., Buntyan, N.D., Vasil’ev, A.N., Verstakova, O.L., Zhuravleva, M.V., Lepakhin, V.K., Korobov, I.V., Merkulov, V.A., Orekhov, S.N., Sakaeva, I.V., Uteshev, D.B., and Yavorskii, A.N., Eds., Moscow: Grif i K, 2012.

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Funding

This work was supported by St. Petersburg State University (application for the development of the material and technical base of St. Petersburg State University no. 33402376) using the equipment of Centers for Collective Use “Chemistry Educational Center,” “Chemical Analysis and Materials Research Center,” “Center for Optical and Laser Materials Research,” and “Magnetic Resonance Research Center” of the St. Petersburg State University.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, O. V. Bobrovskaya, E. A Mashkina, V. V. Novikova, E. A. Hvolis, V. D. Belonogova & D. K. Gulyaev

  2. Perm State National Research University, 614990, Perm, Russia

    R. R. Makhmudov

  3. National Research University ITMO, 197101, St. Petersburg, Russia

    A. N. Yankin

  4. St. Petersburg State University, 199034, St. Petersburg, Russia

    S. E. Danilov

Authors
  1. V. L. Gein
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  2. O. V. Bobrovskaya
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  3. E. A Mashkina
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  4. V. V. Novikova
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  5. R. R. Makhmudov
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  6. A. N. Yankin
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  7. S. E. Danilov
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  8. E. A. Hvolis
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  9. V. D. Belonogova
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  10. D. K. Gulyaev
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Corresponding author

Correspondence to V. L. Gein.

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Gein, V.L., Bobrovskaya, O.V., Mashkina, E.A. et al. Synthesis and Antimicrobial Activity of Methyl (2Z)-4-Aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates and Their Silver Salts. Russ J Gen Chem 90, 822–826 (2020). https://doi.org/10.1134/S1070363220050102

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