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Synthesis of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids

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Abstract

Basing on natural amino acid L-cysteine, commercially available aliphatic aldehydes, 2-acetylsulfanylbenzoyl chloride and 2,2′-disulfandiyldibenzoyl dichloride a synthesis was developed of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids, potential antihypertensive compounds, inhibitors of angiotensin transforming enzyme.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, V.O., Bol’shoi pr. 31, St. Petersburg, 199004, Russia

    А. Yu. Ershov, D. G. Nasledov, M. Yu. Vasil’eva & A. V. Yakimanskii

  2. R&D Test Center (of Medico-Biological Protection), State R&D Institute of Military Medicine, Russian Ministry of Defense, St. Petersburg, Russia

    I. V. Lagoda & L. V. Pavlova

  3. Ryazan Medical University, Ryazan, Russia

    L. Yu. Kuleshova

  4. St. Petersburg State University, St. Petersburg, Russia

    A. V. Yakimanskii

Authors
  1. А. Yu. Ershov
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  2. I. V. Lagoda
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  3. D. G. Nasledov
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  4. M. Yu. Vasil’eva
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  5. L. Yu. Kuleshova
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  6. L. V. Pavlova
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  7. A. V. Yakimanskii
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Corresponding author

Correspondence to А. Yu. Ershov.

Additional information

Original Russian Text © A.Yu. Ershov, I.V. Lagoda, D.G. Nasledov, M.Yu. Vasil’eva, L.Yu. Kuleshova, L.V. Pavlova, A.V. Yakimanskii, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 11, pp. 1646–1650.

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Ershov, А.Y., Lagoda, I.V., Nasledov, D.G. et al. Synthesis of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids. Russ J Org Chem 53, 1682–1686 (2017). https://doi.org/10.1134/S1070428017110124

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  • DOI: https://doi.org/10.1134/S1070428017110124

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