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Acetic Acid-Mediated Synthesis of Kojic Acid Derivatives

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Abstract

A green acetic acid-mediated synthesis of kojic acid derivatives through a multicomponent reaction (MCR) has been developed. This new protocol is simple and efficient; it involves a one-pot reaction of equimolar amounts of kojic acid, aromatic aldehydes, and several active methylene compounds at 90°C in 3 h and results in the formation of a wide range of kojic acid derivatives with high yields. Furthermore, the formation of acyclic product when only kojic acid reacted with benzaldehyde under similar reaction conditions has been explored.

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Funding

Y.B. Kiran is thankful to the University Grants Commission (UGC) for a minor project (MRP-4595/14 SERO/UGC) funding, and L.C.A. Barbosa thanks the National Council for Scientific and Technological Development (CNPq) and the Minas Gerais State Agency for Research and Development (FAPEMIG, Brazil) for financial support.

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Authors and Affiliations

  1. Department of Chemistry, Sree Vidyanikethan Engineering College, 517102, Tirupati, Andhra Pradesh, India

    Y. B. Kiran & G. Rambabu

  2. Centre for Organic and Medicinal Chemistry, VIT University, 632014, Vellore, Tamil Nadu, India

    V. Vijayakumar

  3. Department of Chemistry, ICEx, Universidade Federal de Minas Gerais, MG 31270-901, Belo Horizonte, Brazil

    L. C. A. Barbosa

Authors
  1. Y. B. Kiran
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  2. G. Rambabu
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  3. V. Vijayakumar
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  4. L. C. A. Barbosa
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Correspondence to Y. B. Kiran.

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Kiran, Y.B., Rambabu, G., Vijayakumar, V. et al. Acetic Acid-Mediated Synthesis of Kojic Acid Derivatives. Russ J Org Chem 57, 1158–1166 (2021). https://doi.org/10.1134/S1070428021070162

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