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Polymer gels as artificial soft tissue

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Abstract

Soft tissue consists a main body of biological systems. It is made of hydrogels mainly composed of extra cellular matrix (ECM), which is the three-dimensional highly organized and inter-woven network of proteins and polysaccharides. ECM has three symbolic roles. They are pertinent and excellent mechanical performance, extremely low friction, and effective and selective transportation of solute molecules for cell viability. One of the important goals for gel science would be to design and create hydrogels with critical parameters, which natural tissues possess and eventually to replace them with artificial one.

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References

  1. Y. Osada and K. Kajiwara, Gels Handbook (Academic Press, New York, 2001).

    Google Scholar 

  2. Y. Tanaka, I. Nishio, S. T. Sun, and S. V. Nishio, Science 218, 467 (1973).

    Article  Google Scholar 

  3. Y. Osada, H. Okuzaki, and H. Hori, Nature 355, 242 (1992).

    Article  CAS  Google Scholar 

  4. Y. Osada and S. Ross-Murphy, Sci. Am. 268, 82 (1993).

    Article  CAS  Google Scholar 

  5. Y. Osada and J. P. Gong, Adv. Mater. 10, 827 (1998).

    Article  CAS  Google Scholar 

  6. O. Wichterle, “Hydrogels”, in Encyclopedia of Polymer Science and Technology, Vol. 15, Ed. by H. F. Mark, N. G. Gaylord and N. Bikanes (Interscience, New York, 1971), p. 273.

    Google Scholar 

  7. P. J. Flory, Principles of Polymer Chemistry (Cornell Univ. Press, Ithaca, 1953), Chap. 11.

    Google Scholar 

  8. Y. Okumura and K. Ito, Adv. Mater. 13, 485 (2001).

    Article  CAS  Google Scholar 

  9. K. Haraguchi and T. Takehisa, Adv. Mater. 14, 1120 (2002).

    Article  CAS  Google Scholar 

  10. J. P. Gong, Y. Katsuyama, T. Kurokawa, and Y. Osada, Adv. Mater. 15, 1155 (2003).

    Article  CAS  Google Scholar 

  11. A. Nakayama, A. Kakugo, J. P. Gong, Y. Osada, M. Takai. T. Erata, and S. Kawano, Adv. Funct. Mater. 14, 1124 (2004).

    Article  CAS  Google Scholar 

  12. R. Kishi, K. Hiroki, T. Tominaga, K.I. Sano, H. Okuzaki, J. G. Martinez, T. F. Otero, and Y. Osada, J. Polym. Sci., Part B: Polym. Phys. 50, 790 (2012).

    Article  CAS  Google Scholar 

  13. R. Kishi, K. Kubota, T. Miura, T. Yamaguchi, H. Okuzaki, and Y. Osada, J. Mater. Chem. C 2014(2), 736 (2014).

    Article  Google Scholar 

  14. J. P. Gong, M. Higa, Y. Iwasaki, Y. Katsuyama, and Y. Osada, J. Phys. Chem. B 101, 5487 (1997).

    Article  CAS  Google Scholar 

  15. J. P. Gong, T. Kurokawa, T. Narita, G. Kagata, Y. Osada, G. Nishimura, and M. Kinjo, J. Am. Chem. Soc. 123, 5582 (2001).

    Article  CAS  Google Scholar 

  16. D. Kaneko, T. Tada, T. Kurokawa, J. P. Gong, and Y. Osada, Adv. Mater. 17, 535 (2005).

    Article  CAS  Google Scholar 

  17. W. A. Hodge, R. S. Fijian, K. L. Carlson, R. G. Burgess, W. H. Harris, and R. W. Mann, Proc. Natl. Acad. Sci. U. S. A. 83, 2879 (1986)

    Article  CAS  Google Scholar 

  18. C. W. McCutchen, Lubrication of Joints, the Joints and Synovial Fluid (Academic Press, New York, 1978).

    Google Scholar 

  19. B. N. J. Presson, Sliding Friction: Physical Principles and Applications (Springer, Berlin, 1998), 2nd ed.

    Book  Google Scholar 

  20. Y. Ohsedo, R. Takashina, J. P. Gong, and Y. Osada, Langmiur 20, 6549 (2004).

    Article  CAS  Google Scholar 

  21. J. P. Gong, Y. Iwasaki, Y. Osada, K. Kurihara, and Y. Hamai, J. Phys. Chem. B 103, 6001 (1999).

  22. J. P. Gong, G. Kagata, and Y. Osada, J. Phys. Chem. B 103, 6007 (1999).

    Article  CAS  Google Scholar 

  23. J. P. Gong and Y. Osada, J. Chem. Phys. 109, 8062 (1998).

    Article  CAS  Google Scholar 

  24. A. Kii, J. Xu, J.P. Gong, Y. Osada, and X. M. Zhang, J. Phys. Chem. B 105, 4565 (2001).

    Article  CAS  Google Scholar 

  25. T. Narita, A. Hirai, J. Xu, J. P. Gong, and Y. Osada, Biomacromolecules 1, 162 (2000).

    Article  CAS  Google Scholar 

  26. J. P. Gong, T. Kurokawa, T. Narita, G. Kagata, Y. Osada, G. Nishimura, and M. Kinjo, J. Am. Chem. Soc. 123, 5582 (2001).

    Article  CAS  Google Scholar 

  27. M. R. Wattenbarger, V. A. Bloomfield, Z. Bu, and P. S. Russo, Macromolecules 25, 5263 (1992).

    Article  CAS  Google Scholar 

  28. K. A. Johnson, G. B. Westermann-Clark, and D. O. Shah, Langmuir 5, 932 (1989).

    Article  CAS  Google Scholar 

  29. N. P. Lin and W. M. Deen, J. Colloid Interface Sci. 153, 483 (1992).

    Article  CAS  Google Scholar 

  30. E. M. Johnson, D. A. Berk, R. K. Jain, and W. M. Deen, Biophys. J. 68, 1561 (1995).

    Article  CAS  Google Scholar 

  31. X. Zhang, N. Hirota, T. Narita, J. P. Gong, and Y. Osada, J. Phys. Chem. B 103, 6069 (1999).

    Article  CAS  Google Scholar 

  32. N. Hirota, Y. Kumaki, T. Narita, J. P. Gong, and Y. Osada, J. Phys. Chem. B 104, 9898 (2000).

    Article  CAS  Google Scholar 

  33. D. S. Clague and R. J. Phillips, Phys. Fluids 8, 1720 (1996).

    Article  CAS  Google Scholar 

  34. D. S. Tsai and W. Strieder, Chem. Eng. Commun. 40, 207 (1985).

    Article  Google Scholar 

  35. J. P. Gong, N. Hirota, A. Kakugo, T. Narita, and Y. Osada, J. Phys. Chem. B 104, 9904 (2000)

    Article  CAS  Google Scholar 

  36. P. G. de Gennes, Scaling Concepts in Polymers Physics (Cornell Univ. Press, Ithaca, 1979).

    Google Scholar 

  37. M. Doi and S. F. Edwards, The Theory of Polymer Dynamics (Oxford Univ. Press, Oxford, 1986).

    Google Scholar 

  38. N. Shimamoto, K. Ijiro, K. Sasaki, and Y. Osada, Adv. Mater. 24, 5243 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. RIKEN, Advanced Science Institute, Wako, Saitama, 351-0198, Japan

    Yoshihito Osada

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  1. Yoshihito Osada
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Osada, Y. Polymer gels as artificial soft tissue. Polym. Sci. Ser. C 59, 3–10 (2017). https://doi.org/10.1134/S1811238217010106

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  • DOI: https://doi.org/10.1134/S1811238217010106

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