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Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Breast cancer is the most common malignancy diagnosed in women of childbearing age. A breast cancer diagnosis in this young patient population can be uniquely complex to navigate when considering the potential impact of fertility loss associated with specific gonadotoxic therapies. Another unique challenge for young breast cancer patients is pregnancy-associated breast cancer (PABC), which occurs in approximately 1 of every 3000 pregnancies. Pregnancy adds a layer of complexity to breast cancer treatment planning as many therapies can affect the developing fetus. These two clinical challenges require nuanced multidisciplinary approaches to facilitate optimal treatment outcomes. We sought to review and summarize the management strategy options for both fertility preservation and PABC.

Methods

A guideline and literature review was performed for fertility preservation, young patients with breast cancer, and pregnancy-associated breast cancer.

Results

Fertility preservation options, both established and experimental, are detailed. Suggested clinical practice guidelines for PABC are also presented, which delineate breast cancer treatment recommendations based on pregnancy trimester.

Conclusion

A multidisciplinary approach to patient care, including oncologists and early referral to reproductive specialists, can provide young breast cancer patients with options for fertility preservation. Under the guidance of a multidisciplinary treatment team, PABC can also be diagnosed and treated to permit the best possible outcomes for the mother and the developing fetus.

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Acknowledgment

The authors thank Zachary Pascoe for helpful discussions regarding manuscript preparation. The authors acknowledge financial support from the NIH R01CA214384 (to J. S. Jeruss), A Sister’s Hope Foundation, (J. S. Jeruss), and NIH T32CA009672 (J. S. Jeruss and P. Kandagatla).

Author information

Author notes

  1. Nikita M. Shah and Dana M. Scott have contributed equally to this manuscript.

Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, University of Michigan, Ann Arbor, MI, USA

    Nikita M. Shah MD, Pridvi Kandagatla MD & Jacqueline S. Jeruss MD, Ph.D.

  2. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    Dana M. Scott MD

  3. Department of Surgery, Henry Ford Health System/Wayne State University, Detroit, MI, USA

    Pridvi Kandagatla MD

  4. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    Molly B. Moravek MD

  5. Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Erin F. Cobain MD & Monika L. Burness MD

  6. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

    Jacqueline S. Jeruss MD, Ph.D.

  7. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

    Jacqueline S. Jeruss MD, Ph.D.

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  1. Nikita M. Shah MD
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Shah, N.M., Scott, D.M., Kandagatla, P. et al. Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer. Ann Surg Oncol 26, 1214–1224 (2019). https://doi.org/10.1245/s10434-019-07156-7

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