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The Landmark Series: Preoperative Therapy for Pancreatic Cancer

  • Pancreatic Tumors
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Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

The surgical treatment of pancreas ductal adenocarcinoma (PDAC) is plagued by high rates of distant recurrences despite complete resection, highlighting the importance of systemic therapy. Historically, patients with PDAC have been treated with postoperative therapy, but this sequencing strategy can be associated with the inability to complete therapy due to perioperative complications and prolonged recovery. In addition, a subset of patients progress early, irrespective of whether surgery is performed, highlighting the systemic nature of this disease. Preoperative therapy has increasingly been utilized in clinical practice, but studies examining its benefits are limited. In this Landmark Series, we will review seminal studies for resectable and borderline resectable PDAC.

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Authors and Affiliations

  1. Department of Surgery and the Division of Surgical Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Sameer H. Patel MD, FACS & Syed A. Ahmad MD, FACS

  2. Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Matthew H. G. Katz MD, FACS, FASCO

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  1. Sameer H. Patel MD, FACS
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Patel, S.H., Katz, M.H.G. & Ahmad, S.A. The Landmark Series: Preoperative Therapy for Pancreatic Cancer. Ann Surg Oncol 28, 4104–4129 (2021). https://doi.org/10.1245/s10434-021-10075-1

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