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Sugar in Beverage and the Risk of Incident Dementia, Alzheimer’s disease and Stroke: A Prospective Cohort Study

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Abstract

Background

This study aimed to investigate the association between sugar in beverage and dementia, Alzheimer Disease (AD) dementia and stroke.

Methods

This prospective cohort study were based on the US community-based Framingham Heart Study (FHS). Sugar in beverage was assessed between 1991 and 1995 (5th exam). Surveillance for incident events including dementia and stroke commenced at examination 9 through 2014 and continued for 15–20 years.

Results

At baseline, a total of 1865 (63%) subjects consumed no sugar in beverage, whereas 525 (18%) subjects consumed it in 1–7 servings/week and 593 (29%) in over 7 servings/week. Over an average follow-up of 19 years in 1384 participants, there were 275 dementia events of which 73 were AD dementia. And 103 of 1831 participants occurred stroke during the follow-up nearly 16 years. After multivariate adjustments, individuals with the highest intakes of sugar in beverage had a higher risk of all dementia, AD dementia and stroke relative to individuals with no intakes, with HRs of 2.80(95%CI 2.24–3.50) for all dementia, 2.55(95%CI 1.55–4.18) for AD dementia, and 2.11(95%CI 1.48–3.00) for stroke. And the same results were shown in the subgroup for individuals with median intakes of sugar in beverage.

Conclusion

Higher consumption of sugar in beverage was associated with an increased risk of all dementia, AD dementia and stroke.

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Data Availability

Data described in the manuscript, code book, and analytic code will not be made available because the authors are prohibited from distributing or transferring the data and codebooks on which their research was based to any other individual or entity under the terms of an approved NHLBI Framingham Heart Study Research Proposal and Data and Materials Distribution Agreement through which the authors obtained these data.

References

  1. Gao S, Burney HN, Callahan CM, Purnell CE, Hendrie HC. Incidence of Dementia and Alzheimer Disease Over Time: A Meta-Analysis. J Am Geriatr Soc 2019;67, 1361–1369.

    Article  Google Scholar 

  2. Turana Y, Tengkawan J, Chia YC, Hoshide S, Shin J, Chen CH, Buranakitjaroen P, Nailes J, Park S, Siddique S, Sison J, Ann Soenarta A, Chin Tay J, Sogunuru GP, Zhang Y, Wang JG, Kario K. Hypertension and Dementia: A comprehensive review from the HOPE Asia Network. J Clin Hypertens (Greenwich) 2019;21, 1091–1098.

    Article  Google Scholar 

  3. Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies. J Diabetes Investig 2013;4, 640–650.

    Article  Google Scholar 

  4. Otuyama LJ, Oliveira D, Locatelli D, Machado DA, Noto AR, Galduroz JCF, Prince MJ, Ferri CP. Tobacco smoking and risk for dementia: evidence from the 10/66 population-based longitudinal study. Aging Ment Health, 2019;1–11.

  5. Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T. NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. J Am Heart Assoc 2019;8, e011652.

    Article  Google Scholar 

  6. Matsushita S, Higuchi S. [Alcohol and the Risk of Dementia]. Brain Nerve 2016;68, 819–827.

    PubMed  Google Scholar 

  7. Mozaffarian D. Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Circulation 2016;133, 187–225.

    Article  CAS  Google Scholar 

  8. Huang Y, Pomeranz J, Wilde P, Capewell S, Gaziano T, O’Flaherty M, Kersh R, Whitsel L, Mozaffarian D, Micha R. Adoption and Design of Emerging Dietary Policies to Improve Cardiometabolic Health in the US. Curr Atheroscler Rep 2018;20, 25.

    Article  CAS  Google Scholar 

  9. Walker ME, Xanthakis V, Moore LL, Vasan RS, Jacques PF. Cumulative sugar-sweetened beverage consumption is associated with higher concentrations of circulating ceramides in the Framingham Offspring Cohort. Am J Clin Nutr 2010;111, 420–428.

    Article  Google Scholar 

  10. Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke 2017;48, 1139–1146.

    Article  CAS  Google Scholar 

  11. Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer’s disease in the community. Alzheimers Dement 2017;13, 955–964.

    Article  Google Scholar 

  12. Dawber TR, Meadors GF, Moore FE, Jr. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health Nations Health 1951;41, 279–281.

    Article  CAS  Google Scholar 

  13. Feinleib M, Kannel WB, Garrison RJ, McNamara PM, Castelli WP. The Framingham Offspring Study. Design and preliminary data. Prev Med 1975;4, 518–525.

    Article  CAS  Google Scholar 

  14. American Psychatric Association. Arlington V. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, American Psychiatric Publishing., 2000

  15. Macfarlane GJ, Barnish MS, Jones GT. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and metaanalysis. Ann Rheum Dis 2017;76, 1815–1822.

    Article  Google Scholar 

  16. Weinstein G, Beiser AS, Preis SR, Courchesne P, Chouraki V, Levy D, Seshadri S. Plasma clusterin levels and risk of dementia, Alzheimer’s disease, and stroke. Alzheimers Dement (Amst) 2016;3, 103–109.

    Article  Google Scholar 

  17. Hirahatake KM, Jacobs DR, Shikany JM, Jiang L, Wong ND, Steffen LM, Odegaard AO. Cumulative intake of artificially sweetened and sugar-sweetened beverages and risk of incident type 2 diabetes in young adults: the Coronary Artery Risk Development In Young Adults (CARDIA) Study. Am J Clin Nutr 2019;110, 733–741.

    Article  Google Scholar 

  18. Chun S, Choi Y, Chang Y, Cho J, Zhang Y, Rampal S, Zhao D, Ahn J, Suh BS, Pastor-Barriuso R, Lima JA, Chung EC, Shin H, Guallar E, Ryu S. Sugar-sweetened carbonated beverage consumption and coronary artery calcification in asymptomatic men and women. Am Heart J 2016;177, 17–24.

    Article  CAS  Google Scholar 

  19. Bernstein AM, de Koning L, Flint AJ, Rexrode KM, Willett WC. Soda consumption and the risk of stroke in men and women. Am J Clin Nutr 2012;95, 1190–1199.

    Article  CAS  Google Scholar 

  20. Stephan BC, Wells JC, Brayne C, Albanese E, Siervo M. Increased fructose intake as a risk factor for dementia. J Gerontol A Biol Sci Med Sci 2010;65, 809–814.

    Article  CAS  Google Scholar 

  21. Tey SL, Salleh NB, Henry J, Forde CG. Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake. Int J Obes (Lond) 2017;41, 450–457.

    Article  CAS  Google Scholar 

  22. Orr ME, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer’s disease pathology. Neurobiol Aging 2014;35, 1233–1242.

    Article  CAS  Google Scholar 

  23. Stranahan AM, Norman ED, Lee K, Cutler RG, Telljohann RS, Egan JM, Mattson MP. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008;18, 1085–1088.

    Article  Google Scholar 

  24. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gomez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002;112, 803–814.

    Article  CAS  Google Scholar 

  25. Hao G, Pollock NK, Harris RA, Gutin B, Su S, Wang X. Associations between muscle mass, physical activity and dietary behaviour in adolescents. Pediatr Obes 2019;14, e12471.

    Article  CAS  Google Scholar 

  26. Wolkenstein P, Misery L, Amici JM, Maghia R, Branchoux S, Cazeau C, Voisard JJ, Taieb C. Smoking and dietary factors associated with moderate-to-severe acne in French adolescents and young adults: results of a survey using a representative sample. Dermatology 2015;230, 34–39.

    Article  CAS  Google Scholar 

  27. Stephen R, Hongisto K, Solomon A, Lonnroos E. Physical Activity and Alzheimer’s Disease: A Systematic Review. J Gerontol A Biol Sci Med Sci 2017;72, 733–739.

    PubMed  Google Scholar 

  28. Moon Y, Choi YJ, Kim JO, Han SH. Muscle profile and cognition in patients with Alzheimer’s disease dementia. Neurol Sci 2018;39, 1861–1866.

    Article  Google Scholar 

  29. Arnoldussen IA, Kiliaan AJ, Gustafson DR. Obesity and dementia: adipokines interact with the brain. Eur Neuropsychopharmacol 2014;24, 1982–1999.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank the National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, Chongqing Mental Health Center and Jiangjin Central Hospital of Chongqing.

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Author notes

  1. Hongyun Miao and Ken Chen are co-first author

Authors and Affiliations

  1. Department of Endocrinology, Jiangjin Central Hospital of Chongqing, Chongqing, China

    Hongyun Miao

  2. Out-Patient Department, Jinzi Mountain Hospital of Chongqing Mental Health Center, Chongqing, 401147, China

    Ken Chen

  3. Department of Pediatrics, Jiangjin Central Hospital of Chongqing, No.725 Jiangzhou Street, Jiangjin District, Chongqing, 402260, China

    Xiaoyong Yan

  4. Department of Geriatrics, Chongqing Mental Health Center, Chongqing, China

    Fei Chen

  5. First Psychogeriatric Ward, Jinzi Mountain Hospital of Chongqing Mental Health Center, No 102, Jinzi Mountain, Jiangbei, District, Chongqing, 401147, China

    Fei Chen

Authors
  1. Hongyun Miao
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  2. Ken Chen
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  4. Fei Chen
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Corresponding author

Correspondence to Fei Chen.

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The study procedures followed were in accordance with the ethical standards of the Institutional Review Board and the Principles of the Declaration of Helsinki.

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The authors declare that they have no conflicts of interest.

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None. All authors have read the journal’s authorship agreement and that the manuscript has been reviewed by and approved by all named authors.

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Miao, H., Chen, K., Yan, X. et al. Sugar in Beverage and the Risk of Incident Dementia, Alzheimer’s disease and Stroke: A Prospective Cohort Study. J Prev Alzheimers Dis 8, 188–193 (2021). https://doi.org/10.14283/jpad.2020.62

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  • DOI: https://doi.org/10.14283/jpad.2020.62

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