Abstract
We herein report the detection of folic acid (FA) via the fluorometric method using water-soluble AgInS2 quantum dots (QDs). The optical analysis showed that the addition of FA to AgInS2 QDs results in significant, blue-shifted photoluminescence emission. A linear plot of the blueshift in the photoluminescence wavelength position against FA concentration was obtained in the range of 0.03–33 µM with the detection limit of 52 nM. Interference study showed the selective detection of FA in the presence of other biomolecules. The as-synthesized AgInS2 QDs can be employed as an optical sensor for the rapid detection of FA in aqueous solutions.
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References
R. Moll and B. Davis: Iron, vitamin B12 and folate. Medicine 45, 198–203 (2017).
R. Green, L.H. Allen, A.-L. Bjørke-Monsen, A. Brito, J.-L. Guéant, J.W. Miller, A.M. Molloy, E. Nexo, S. Stabler, B.-H. Toh, P.M. Ueland, and C. Yajnik: Vitamin B 12 deficiency. Nat. Rev. Dis. Primers 3, 17040 (2017).
S. Liu, J. Hu, and X. Su: Detection of ascorbic acid and folic acid based on water-soluble CuInS2 quantum dots. Analyst 137, 4598–4604 (2012).
S.J. Duthie: Folic acid deficiency and cancer: mechanisms of DNA instability. Br. Med. Bull 55, 578–592 (1999).
S. Chakravarty, P. Dutta, S. Kalita, and N.S. Sarma: PVA-based nanobio-sensor for ultrasensitive detection of folic acid by fluorescence quenching. Sens. Actuators B Chem 232, 243–250 (2016).
R. Póo-Prieto, D.B. Haytowitz, J.M. Holden, G. Rogers, S.F. Choumenkovitch, P.F. Jacques, and J. Selhub: Use of the affinity/HPLC method for quantitative estimation of folic acid in enriched cereal-grain products. J. Nutr. 136, 3079–3083 (2006).
F. Chekin, F. Teodorescu, Y. Coffinier, G.H. Pan, A. Barras, R. Boukherroub, and S. Szunerits: MoS2/reduced graphene oxide as active hybrid material for the electrochemical detection of folic acid in human serum. Biosens. Bioelectron. 85, 807–813 (2016).
J.L. Manzoori, A. Jouyban, M. Amjadi, and J. Soleymani: Spectrofluorimetric determination of folic acid in tablets and urine samples using. Luminescence 1, 106–111 (2011).
F. Yu, M. Cui, F. Chen, Y. Gao, J. Wei, and Y. Ding: Highly sensitive spectrofluori- metric determination of trace amounts of folic acid using a oxytetracycline-terbium (iii) probe. Anal. Lett. 42, 178–189 (2009).
M. Geszke-Moritz, G. Clavier, J. Lulek, and R. Schneider: Copper-or manganese- doped ZnS quantum dots as fluorescent probes for detecting folic acid in aqueous media. J. Lumin. 132, 987–991 (2012).
X. Li and L. Chen: Fluorescence probe based on an amino-functionalized fluorescent magnetic nanocomposite for detection of folic acid in serum. ACS Appl. Mater. Interfaces 8, 31832–31840 (2016).
A.A. Ensafi, P. Nasr-Esfahani, and B. Rezaei: Simultaneous detection of folic acid and methotrexate by an optical sensor based on molecularly imprinted polymers on dual-color CdTe quantum dots. Anal. Chim. Acta 996, 64–73 (2017).
B.M. May, S. Parani, and O.S. Oluwafemi: Detection of ascorbic acid using green synthesized AgInS2 quantum dots. Mater. Lett. 236, 432–435 (2019).
X. Kang, Y. Yang, L. Huang, Y. Tao, L. Wang, and D. Pan: Large-scale synthesis of water-soluble CuInSe2/ZnS and AgInSe2/ZnS core/shell quantum dots. Green Chem. 17, 4482–4488 (2015).
I.A. Mir, V.S. Radhakrishanan, K. Rawat, T. Prasad, and H.B. Bohidar: Bandgap tunable AgInS based quantum dots for high contrast cell imaging with enhanced photodynamic and antifungal applications. Sci. Rep. 8, 9322 (2018).
S. Chen, M. Ahmadiantehrani, J. Zhao, S. Zhu, A.G. Mamalis, and X. Zhu: Heat-up synthesis of Ag–In–S and Ag–In–S/ZnS nanocrystals: effect of indium precursors on their optical properties. J. Alloys. Compd. 665, 137–143 (2016).
X. Kang, L. Huang, Y. Yang, and D. Pan: Scaling up the aqueous synthesis of visible light emitting multinary AgInS2/ZnS core/shell quantum dots. J. Phys. Chem. C 119, 7933–7940 (2015).
A.E. Raevskaya, M.V. Ivanchenko, M.A. Skoryk, and O.L. Stroyuk: Brightly luminescent colloidal Ag–In–S nanoparticles stabilized in aqueous solutions by branched polyethyleneimine. J. Lumin. 178, 29–300 (2016).
S. Hekmatimoghaddam, A. Jebali, and M. Dargahi: Folic acid-functionalized gold and silver nanoparticles: their cytotoxic effect on cancerous myeloid cells with microwave irradiation. Nano Life 3, 1350003 (2013).
K.A. Rawat, R.K. Singhal, and S.K. Kailasa: One-pot synthesis of silver nanoparticles using folic acid as a reagent for colorimetric and fluorimet-ric detections of 6-mercaptopurine at nanomolar concentration. Sens. Actuators B Chem. 249, 30–38 (2017).
D. Su, D.X. Yang, Q. Xia, Q. Zhang, F. Chai, C. Wang, and F. Qu: Folic acid functionalized silver nanoparticles with sensitivity and selectivity colouri-metric and fluorescent detection for Hg2+ and efficient catalysis. Nanotechnology 25, 355702 (2014).
Acknowledgments
The authors would like to thank UJ-Global Excellence Stature, National Research Foundation (N.R.F.) under Scarce Skills and Innovation scholarship, Competitive Programme for Rated Researchers (CPRR), Grant No. 106060, and University of Johannesburg research committee (URC) and Faculty of Science research committee (FRC) for financial support.
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May, B.M.M., Parani, S., Rajendran, J.V. et al. Selective detection of folic acid in the midst of other biomolecules using water-soluble AgInS2 quantum dots. MRS Communications 9, 1306–1310 (2019). https://doi.org/10.1557/mrc.2019.124
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DOI: https://doi.org/10.1557/mrc.2019.124