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Azobenzene functionalized mesoporous AlMCM-41-type support for drug release applications

  • Research Article
  • RICCCE 18
  • Published:
Central European Journal of Chemistry

Abstract

A light-responsive material, aminoazobenzene functionalized AlMCM-41, was synthesized and characterized in order to be used as carrier for drug delivery devices. The light-induced hydrophobic-hydrophilic switching effect of azobenzene functionalized aluminosilicate was exploited in the release of irinotecan, a cytostatic drug. To obtain the functionalized mesoporous support, an azobenzene-silane precursor was synthesized by coupling 4-(4′-aminophenylazo) benzoic acid with 3-aminopropyl triethoxysilane and further grafted on AlMCM-41. The azobenzene functionalized mesoporous aluminosilicate exhibited no significant toxicity towards murine fibroblast healthy cells and a reduced toxicity towards murine melanocyte cells. The hybrid materials obtained by loading irinotecan on AlMCM-41 (wt. 35.4%) and aminoazobenzene modified AlMCM-41 (wt. 22%), respectively were characterized by FTIR, small and wide angle XRD, N2 adsorption-desorption isotherms and DSC analyses. A two-fold increase in the drug release rate from azobenzene functionalized aluminosilicate in phosphate buffer solution under UV irradiation was noticed, as compared with dark conditions. Moreover, the azobenzene functionalization of AlMCM-41 significantly increased the irinotecan delivery rate and total cumulative release in comparison with the pristine AlMCM-41 in similar conditions.

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Authors and Affiliations

  1. Faculty of Applied Chemistry and Materials Science, University “Politehnica” of Bucharest, Bucharest, 011061, Romania

    Raul-Augustin Mitran, Daniela Berger, Laura Băjenaru, Silviu Năstase & Cristian Matei

  2. SARA Pharm Solutions, Bucharest, 050912, Romania

    Raul-Augustin Mitran

  3. “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy of Sciences, Bucharest, 060021, Romania

    Cristian Andronescu

Authors
  1. Raul-Augustin Mitran
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  2. Daniela Berger
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  3. Laura Băjenaru
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  4. Silviu Năstase
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  5. Cristian Andronescu
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  6. Cristian Matei
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Corresponding author

Correspondence to Cristian Matei.

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Mitran, RA., Berger, D., Băjenaru, L. et al. Azobenzene functionalized mesoporous AlMCM-41-type support for drug release applications. cent.eur.j.chem. 12, 788–795 (2014). https://doi.org/10.2478/s11532-014-0534-2

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  • DOI: https://doi.org/10.2478/s11532-014-0534-2

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