Overview
- Describes homology modeling steps from first principles
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 857)
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Table of contents (18 protocols)
Keywords
About this book
Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
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Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.
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Editors and Affiliations
Bibliographic Information
Book Title: Homology Modeling
Book Subtitle: Methods and Protocols
Editors: Andrew J. W. Orry, Ruben Abagyan
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-61779-588-6
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media,LLC 2012
Hardcover ISBN: 978-1-61779-587-9Published: 10 February 2012
Softcover ISBN: 978-1-4939-5880-1Published: 23 August 2016
eBook ISBN: 978-1-61779-588-6Published: 10 February 2012
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XI, 419
Number of Illustrations: 34 b/w illustrations, 55 illustrations in colour
Topics: Protein Science, Protein Structure