Skip to main content
SpringerLink
Log in
Birkhäuser

Tetracyclines in Biology, Chemistry and Medicine

  • Book
  • © 2001

Overview

Editors:
  1. Mark Nelson

    1. Paratek Pharmaceuticals, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Wolfgang Hillen

    1. Lehrstuhl für Mikrobiologie, Friedrich-Alexander Universität, Erlangen, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Robert A. Greenwald

    1. Division of Rheumatology, Long Island Jewish Medical Center, New Hyde Park, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Chemistry, biology and microbiologic action of tetracyclines

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. The chemistry and cellular biology of the tetracyclines

      • Mark L. Nelson
      Pages 3-63

    3. Proton and metal ion binding of tetracyclines

      • Siegfried Schneider
      Pages 65-104

  3. Tetracycline-dependent gene regulation: A versatile tool for all organisms

    1. Front Matter

      Pages 105-105
      Download chapter PDF

    2. Gene regulation by the tetracycline-inducible Tet repressor-operator system — molecular mechanisms at atomic resolution

      • Winfried Hinrichs, Christiane Fenske
      Pages 107-123

    3. Regulation of gene expression in yeast and plants by tetracycline-dependent regulatory systems

      • Elisabeth Pook
      Pages 125-137

    4. Tetracyclines in the control of gene expression in eukaryotes

      • Manfred Gossen, Hermann Bujard
      Pages 139-157

    5. Tetracycline-regulated gene expression to study oncogenes in vivo

      • Jeffrey E. Kudlow
      Pages 159-175

    6. Interactions of tetracyclines with RNA

      • Christian Berens
      Pages 177-196

  4. Use of tetracyclines as non-antimicrobial medicinal agents

    1. Front Matter

      Pages 197-197
      Download chapter PDF

    2. Biological, non-antibiotic properties of semi-synthetic and chemically modified tetracyclines — a structured, annotated bibliography

      • Robert A. Greenwald, Lome M. Golub
      Pages 199-217

    3. Tetracycline consumption in prehistory

      • George J. Armelagos, Kristi Kolbacher, Kristy Collins, Jennifer Cook, Maria Krafeld-Daugherty
      Pages 219-236

    4. Tetracycline treatment of periodontal disease: antimicrobial and non-antimicrobial mechanisms

      • Maria Emanuel Ryan, Danielle M. Baker
      Pages 237-265

    5. Inhibition of matrix metalloproteinases (MMPs) by tetracyclines

      • Roeland Hanemaaijer, Natascha van Lent, Timo Sorsa, Tuula Salo, YrjŐ, T. Konttinen et al.
      Pages 267-281

    6. Structure/function studies of doxycycline effects on matrix metalloproteinase activity and cartilage degeneration

      • N Gerald, Jr Smith, Karen A Hasty
      Pages 283-293

    7. Regulation of inflammatory mediators by tetracyclines

      • Mukundan G. Attur, Mandar N. Dave, Nirupama Mohandas, Indravadan R. Patel, Steven B. Abramson, Ashok R. Amin
      Pages 295-310

    8. Tetracyclines and autoimmunity

      • Helena Marzo-Ortega, Roland M Strauss, Paul Emery
      Pages 311-324

    9. Tetracycline photodynamics

      • Brad R. Zerler
      Pages 325-332

  5. Back Matter

    Pages 333-336
    Download chapter PDF
Back to top

Keywords

About this book

The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century. Initially discovered as an antibiotic in 1947, the four­ ringed molecule has captured the fancy of chemists and biologists over the ensuing decades. Of further interest, as described in the chapter by George Armelagos, tetracyclines were already part of earlier cultures, 1500-1700 years ago, as revealed in traces of drug found in Sudanese Nubian mummies. The diversity of chapters which this book presents to the reader should illus­ trate the many disciplines which have examined and seen benefits from these fascinating natural molecules. From antibacterial to anti-inflammatory to anti­ autoimmunity to gene regulation, tetracyclines have been modified and redesigned for various novel properties. Some have called this molecule a biol­ ogist's dream because of its versatility, but others have seen it as a chemist's nightmare because of the synthetic chemistry challenges and "chameleon-like" properties (see the chapter by S. Schneider).

Editors and Affiliations

  • Paratek Pharmaceuticals, Boston, USA

    Mark Nelson

  • Lehrstuhl für Mikrobiologie, Friedrich-Alexander Universität, Erlangen, Germany

    Wolfgang Hillen

  • Division of Rheumatology, Long Island Jewish Medical Center, New Hyde Park, USA

    Robert A. Greenwald

Bibliographic Information

  • Book Title: Tetracyclines in Biology, Chemistry and Medicine

  • Editors: Mark Nelson, Wolfgang Hillen, Robert A. Greenwald

  • DOI: https://doi.org/10.1007/978-3-0348-8306-1

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2001

  • Hardcover ISBN: 978-3-7643-6282-9Published: 01 October 2001

  • Softcover ISBN: 978-3-0348-9511-8Published: 25 October 2012

  • eBook ISBN: 978-3-0348-8306-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 336

  • Topics: Biochemistry, general, Pharmacology/Toxicology, Medical Biochemistry

Publish with us

Policies and ethics

Back to top

Search

Navigation