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Antidepressants

  • Book
  • © 2001

Overview

Editors:
  1. Brian E. Leonard

    1. Pharmacology Department, University College Galway, Galway, Ireland

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Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-X
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  2. Clinical issues

    1. Front Matter

      Pages 1-1
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    2. Long-term course, comorbidity and long-term outcome in depressive disorders

      • Kerstin Bingefors, Lisa Ekselius, Lars von Knorring
      Pages 3-19

    3. Do antidepressants really take several weeks to show effect?

      • Jules Angst, Hans H. Stassen
      Pages 21-30

    4. Commentary on the limitation of antidepressants in current use

      • Stephen M. Stahl
      Pages 31-43

  3. Mechanisms of action

    1. Front Matter

      Pages 45-45
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    2. Mechanisms underlying the speed of onset of antidepressant response

      • Caroline McGrath, Trevor R. Norman
      Pages 47-61

    3. Calcium signaling cascades, antidepressants and major depressive disorders

      • Ian A. Paul
      Pages 63-79

  4. Markers of depression

    1. Front Matter

      Pages 81-81
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    2. The hypothalamic-pituitary-adrenal axis and antidepressant action

      • Timothy G. Dinan
      Pages 83-94

    3. Neuroendocrine markers of depression and antidepressant drug action

      • Philip J. Cowen
      Pages 95-107

    4. Brain cytokines and the psychopathology of depression

      • Brian E. Leonard
      Pages 109-120

  5. The future of antidepressants

    1. Front Matter

      Pages 121-121
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    2. Chemistry and pharmacology of novel antidepressants

      • John S. Andrews, Roger M. Pinder
      Pages 123-145

  6. Back Matter

    Pages 147-150
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Keywords

About this book

Important clinical issues as the outcome of long term treatment with antidepressants, the time of onset of the antidepressant response and the limitations of the antidepressants currently available are covered in this monograph. Leading researchers in the area of clinical and experimental psychopharmacology critically assess the progress in their specialist fields. The mechanisms of action of antidepressants are considered, followed by clinical research into the role of the hypothalamic-pituitary-adrenal axis and the immune system in the biology of depression and in response to treatment. The final chapter deals with the important chemical entities now undergoing development as antidepressants. The purpose of this monograph is not only to inform but also to stimulate research into the biology of depression and the mechanisms behind the action of effective antidepressants. This monograph is of interest to psychiatrists, psychologists, pharmacologists, neuroscientists and endocrinologists.

Editors and Affiliations

  • Pharmacology Department, University College Galway, Galway, Ireland

    Brian E. Leonard

Bibliographic Information

  • Book Title: Antidepressants

  • Editors: Brian E. Leonard

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-8344-3

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2001

  • Hardcover ISBN: 978-3-7643-5933-1Published: 01 December 2000

  • Softcover ISBN: 978-3-0348-9526-2Published: 23 October 2012

  • eBook ISBN: 978-3-0348-8344-3Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: X, 150

  • Topics: Psychopharmacology, Neurosciences

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