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Genetic Instability and Tumorigenesis

  • Book
  • © 1997

Overview

Editors:
  1. Michael B. Kastan

    1. Johns Hopkins Hospital, Ross 345, Baltimore, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 221)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-vii
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  2. Genetic Instability and Tumorigenesis: Introduction

    • M. B. Kastan
    Pages 1-4

  3. Genomic Stability and Instability: A Working Paradigm

    • K. C. Cheng, L. A. Loeb
    Pages 5-18

  4. Surveillance and Genome Stability in Budding Yeast: Implications for Mammalian Carcinogenesis

    • F. Spencer
    Pages 19-35

  5. Genomic Instability and Its Role in Neoplasia

    • T. D. Tlsty
    Pages 37-46

  6. Role of DNA Excision Repair Gene Defects in the Etiology of Cancer

    • J. M. Ford, P. C. Hanawalt
    Pages 47-70

  7. Chromosome Instability Syndromes: Lessons for Carcinogenesis

    • M. S. Meyn
    Pages 71-148

  8. Genetic Alterations in Human Tumors

    • K. R. Cho, L. Hedrick
    Pages 149-176

  9. Back Matter

    Pages 177-183
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Keywords

About this book

M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe­ notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is "how do these genetic changes occur in somatic cells?". Epidemiologic data suggest that exposure to environmental carcinogens con­ tributes to the genesis of at least 80% of all human cancers (DOLL and PETO 1981). Thus, it is natural to suspect that the genetic changes in somatic cells which con­ tribute to the transformed phenotype arise from DNA damage caused by such exposures. Therefore, understanding how cells respond to DNA-damaging agents is likely to be an important component of our understanding of the genesis of human tumors.

Editors and Affiliations

  • Johns Hopkins Hospital, Ross 345, Baltimore, USA

    Michael B. Kastan

Bibliographic Information

  • Book Title: Genetic Instability and Tumorigenesis

  • Editors: Michael B. Kastan

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-60505-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1997

  • Softcover ISBN: 978-3-642-64434-4Published: 28 September 2011

  • eBook ISBN: 978-3-642-60505-5Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 180

  • Topics: Cancer Research, Cell Biology, Biochemistry, general, Environmental Health

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