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Gangliosides and Modulation of Neuronal Functions

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Hinrich Rahmann

    1. Zoological Institute, University of Stuttgart-Hohenheim, Stuttgart 70, Germany

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Part of the book series: Nato ASI Subseries H: (ASIH, volume 7)

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Table of contents (61 papers)

  1. Front Matter

    Pages I-XVII
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  2. Fundamentals for Research on Function of Gangliosides

    1. Front Matter

      Pages 1-1
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    2. History of Ganglioside Research

      • T. Yamakawa
      Pages 3-15

    3. Fundamentals of the Biological Properties of Sialic Acids

      • R. Schauer, G. Reuter
      Pages 17-35

    4. Fundamentals of Ganglioside Structures

      • H. Wiegandt
      Pages 37-47

    5. Fundamentals of Structural Analysis of Glycosphingolipids by Proton Nuclear Magnetic Resonance Spectroscopy

      • Robert K. Yu
      Pages 49-70

    6. Fundamentals of the Application of MS and NMR in the Study of Ganglioside Structure

      • H. Egge, J. Peter-Katalinić
      Pages 71-85

    7. Computer Predictions of Glycosphingolipid Conformation

      • C. H. Wynn
      Pages 87-99

    8. Fundamentals of Physico-Chemical Properties of Gangliosides in Solution

      • M. Corti, L. Cantù, S. Sonnino
      Pages 101-118

    9. Fundamentals of Physico-Chemistry of Glycolipids in Membranes

      • C. W. M. Grant
      Pages 119-138

    10. Peculiarities of Ganglioside-CA2+-Interactions

      • W. Probst, H. Rahmann
      Pages 139-154

    11. Isolation and Analysis of Gangliosides with O-Acetylated Sialic Acids

      • G. Reuter, R. Schauer
      Pages 155-165

    12. Up-To-Date Chromatography of Gangliosides

      • S. Ando, H. Waki, K. Kon, Y. Kishimoto
      Pages 167-177

    13. The Use of GM1 Alkaline Hydrolysis Products for the Preparation of Ganglioside Molecular Species and Ganglioside Derivates

      • G. Kirschner, S. Sonnino, D. Acquotti, G. Tettamanti
      Pages 179-180

    14. Pyrene-Labeled Gangliosides: Micellar Properties in Aqueous Solution, Lateral Diffusion and Thermotropic Behaviour in Phosphatidylcholine Bilayer

      • M. Ollmann, G. Schwarzmann, K. Sandhoff, H.-J. Galla
      Pages 181-182

    15. Influence of Ca2+ and Temperature Changes on the Surface Requirement of Gangliosides and Phospholipids in Monolayers

      • H. Beitinger, W. Probst, H. Rahmann, G. Schwarzmann, D. Möbius
      Pages 183-184

    16. Stablility of Ganglioside Monolayers at a Liquid/Liquid Interface. A polarographic study of the Ca2+-effect

      • M. Wörner, H. Rau, W. Probst, H. Rahmann
      Pages 185-186

  3. Back Matter

    Pages 187-188
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  4. Brain Ganglioside Metabolism

    1. Front Matter

      Pages 189-189
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    2. Fundamentals of Brain Ganglioside Biosynthesis

      • G. Tettamanti, R. Ghidoni, M. Trinchera
      Pages 191-204
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Keywords

About this book

The NATO Advanced Research Workshop on "Gangliosides and Modu­ lation of Neuronal Functions" was held at the University of Stutt­ gart-Hohenheim, Federal Republic of Germany, on October 20 - 24, 1986. About 70 participants from 10 countries presented papers on a wide range of topics all concerning the ganglioside theme. The content of the workshop consisted of the following chap­ ters: (1) Fundamentals for research on function of gangliosides; (2) Brain ganglioside metabolism; (3) Cell specific distribution and differentiation-related ex­ pression of brain gangliosides; (4) Gangliosides and neuronal plasticity; (5) Bio-medical potential of exogenous ganglioside application on neuronal function; and (6) Critical assessments on aspects of ganglioside therapy. The aim of the workshop was to sum up and discuss the present knowledge in the respective fields. Despite intensive research on gangliosides ever since Ernst Klenk discovered them in 1936, the biological function of. these amphiphilic, "sphinx-like" glycosphingo­ lipids remains elusive. Over the past few years, several thousands of articles on gangliosides have been published demonstrating very special properties of these glycolipids and their possible in­ volvement in diverse biological phenomena. As far as we know up to the present time, these properties may be due to particular physico-chemical attributes of these compounds, especially in com­ bination with calcium. The results obtained so far have shed light not only on pos­ sible functional roles of gangliosides with regard to cellular induction and organization, but have also unexpectedly opened up VI a whole new field of therapeutic applications for these compounds.

Editors and Affiliations

  • Zoological Institute, University of Stuttgart-Hohenheim, Stuttgart 70, Germany

    Hinrich Rahmann

Bibliographic Information

  • Book Title: Gangliosides and Modulation of Neuronal Functions

  • Editors: Hinrich Rahmann

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-71932-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-642-71934-9Published: 17 November 2011

  • eBook ISBN: 978-3-642-71932-5Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: XVII, 647

  • Topics: Biochemistry, general, Neurosciences

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