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Hepatitis C Virus II

Infection and Disease

  • Book
  • © 2016

Overview

Editors:
  1. Tatsuo Miyamura

    1. National Institute of Infectious Disease , Tokyo, Japan

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  2. Stanley M. Lemon

    1. Departments of Medicine and Microbiology, The Univ of N Carolina at Chapel Hill Departments of Medicine and Microbiology, Chapel Hill, USA

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  3. Christopher M. Walker

    1. Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital , Ohio, USA

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  4. Takaji Wakita

    1. National Institute of Infectious Disease, Tokyo, Japan

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  • Written by top researchers who have lead this field since the discovery of hepatitis C virus

  • Provide a concise and current review of the state of this rapidly advancing field

  • Strong focus on rapid advances in treating and managing hepatitis C infection

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-ix
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  2. Chronic Hepatitis C

    1. Front Matter

      Pages 1-1
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    2. Natural History of Chronic Hepatitis C

      • Marc G. Ghany, T. Jake Liang
      Pages 3-55

    3. The Multifaceted Features of HCV Infection Beyond the Liver

      • Kazuhiko Koike
      Pages 57-78

    4. Hepatic Fibrosis in Hepatitis C

      • Melissa A. Sheiko, Hugo R. Rosen
      Pages 79-108

    5. Hepatocellular Carcinoma and Hepatitis C Virus

      • Sheng-Han Wang, Shiou-Hwei Yeh, Pei-Jer Chen
      Pages 109-136

    6. HCV, Alcohol, and the Liver

      • Terence N. Bukong, Banishree Saha, Gyongyi Szabo
      Pages 137-163

    7. Extrahepatic Replication of HCV

      • Wen-Chi Su, Keigo Machida, Michael M. C. Lai
      Pages 165-184

  3. HCV Infections in Special Populations

    1. Front Matter

      Pages 185-185
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    2. Hepatitis C Virus Infection in Pregnancy and Childhood

      • Jessica Wen, Samantha Ohmer, Jonathan Honegger
      Pages 187-222

  4. Approaches to Therapy

    1. Front Matter

      Pages 223-223
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    2. Host Genetics and Responses to Antiviral Therapy in Chronic Hepatitis C

      • Yasuhito Tanaka, Masashi Mizokami
      Pages 225-241

    3. Viral Variation and Response to Therapy

      • Shinya Maekawa, Nobuyuki Enomoto
      Pages 243-256

    4. HCV NS3/4A Protease Inhibitors and the Road to Effective Direct-Acting Antiviral Therapies

      • Nicolas Tremblay, Alex Young Park, Daniel Lamarre
      Pages 257-285

    5. Mechanism of Action of Direct-Acting Antivirals: New Insights into the HCV Life Cycle

      • Sara E. Williford, David R. McGivern
      Pages 287-301

    6. Modeling HCV Dynamics in Clinical Practice to Personalize Antiviral Therapy

      • Piero Colombatto, Ferruccio Bonino, Luigi Civitano, Filippo Oliveri, Gabriele Ricco, Sergio Iannazzo et al.
      Pages 303-321

  5. Prevention and Control of HCV Infection

    1. Front Matter

      Pages 323-323
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    2. Prophylactic Vaccines for the Hepatitis C Virus

      • Andrea L. Cox
      Pages 325-346

    3. Global Control of Hepatitis C Virus Infection

      • Tatsuo Miyamura
      Pages 347-368

  6. Back Matter

    Pages 369-372
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Keywords

About this book

This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.

Reviews

“This multiauthored book covers a wide array of aspects of infection with hepatitis C, from its natural history to the mechanisms of pathogenicity and the mechanisms of antiviral therapy. … The book is written for a broad audience of scientists, clinicians, and others. Scientists and researchers, as well as trainees with a special interest in hepatitis C, will be best served by this book. … This book does a very nice job of explaining the natural history of hepatitis C.” (Cezarina Mindru, Doody's Book Reviews, February, 2017)

Editors and Affiliations

  • National Institute of Infectious Disease , Tokyo, Japan

    Tatsuo Miyamura

  • Departments of Medicine and Microbiology, The Univ of N Carolina at Chapel Hill Departments of Medicine and Microbiology, Chapel Hill, USA

    Stanley M. Lemon

  • Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital , Ohio, USA

    Christopher M. Walker

  • National Institute of Infectious Disease, Tokyo, Japan

    Takaji Wakita

About the editors

Tatsuo Miyamura M.D. PhD. (Jikei University, Japan)

Stanley M.Lemon M.D. PhD.(The University of North Carolina, USA) 

Christopher M. Walker PhD. (The Research Institute at Nationwide Children’s Hospital, USA)

Takaji Wakita M.D. PhD. (National Institute of Infectious Diseases, Japan)

Bibliographic Information

  • Book Title: Hepatitis C Virus II

  • Book Subtitle: Infection and Disease

  • Editors: Tatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita

  • DOI: https://doi.org/10.1007/978-4-431-56101-9

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2016

  • Hardcover ISBN: 978-4-431-56099-9Published: 08 November 2016

  • Softcover ISBN: 978-4-431-56776-9Published: 29 June 2018

  • eBook ISBN: 978-4-431-56101-9Published: 28 October 2016

  • Edition Number: 1

  • Number of Pages: IX, 372

  • Number of Illustrations: 2 b/w illustrations, 23 illustrations in colour

  • Topics: Hepatology, Virology, Infectious Diseases, Public Health

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