Abstract
Very recently, we discovered that women with Sjögren’s syndrome exhibit one of two distinct profiles in the polar lipid fraction of their meibomian gland secretions (Fig. 1). The first pattern is characterized by a single predominant peak eluting early on in the total ion current during HPLC analysis. The second pattern is characterized by multiple peaks spread over time. To begin to explore the mechanism(s) underlying these differences, we sought to determine whether the nutrient intake, and particularly the lipid consumption, of Sjögren’s syndrome patients may vary between those individuals expressing the “single” versus the “multiple” profile.
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Sullivan BD, Evans JE, Dana MR, Sullivan DA. Impact of androgen deficiency on the lipid profiles in human meibomian gland secretions. Adv Exp Med Biol 2001; in press.
Sullivan BD, Evans JE, Sullivan RM, Schaumberg DA, Dana MR, Sullivan DA. Impact of hormone replacement therapy on the lipid profile of meibomian gland secretions in postmenopausal women. Manuscript submitted, 2001.
Willett WC, Reynolds RD, Cottrell-Hoehner S, Sampson L, Browne ML. Validation of a semiquantitative food frequency questionnaire: comparison with a 1-year diet record. J Am Diet Assoc 1987;87:43–47.
London SJ, Sacks FM, Caesar J, Stampfer MJ, Siguel E, Willett WC. Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal US women. Am J Clin Nutr 1991;54:340–345.
Stryker WS, Sampson L, Stampfer MJ, Colditz GA and Willett WC. Contributions of specific foods to absolute intake and between-person variation of nutrient consumption. J Am Diet Assoc 1991;91:172–178.
Hu FB, Rimm E, Smith-Warner SA, et al. Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr 1999;69:243–249.
Chandrasekar B, Fernandes G. Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by ω-3 lipids in murine lupus nephritis. Biochem Biophys Res Comm 1994;200:893–898.
Calder PC. n-3 polyunsaturated fatty acids and cytokine production in health and disease. Ann Nutr Metab 1997;41:203–234.
Shapiro JA, Koepsell TD, Voigt LF, Dugowson CE, Kestin M, Nelson JL. Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology 1996;7:256–263.
Reifen R, Blank M, Afek A, et al. Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus. Lupus 1998;7:192–197.
Alexander JW. Immunonutrition: the role of omega-3 fatty acids. Nutrition 1998;14:627–633.
Venkatraman JT, Chu WC. Effects of dietary omega-3 and omega-6 lipids and vitamin E on serum cytokines, lipid mediators and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr 1999;18:602–613.
Fernandes G, Venkatraman J, Khare A, Horbach GJMJ, Friedrichs W. Modulation of gene expression in autoimmune disease and aging by food restriction and dietary lipids. PSEBM 1990;193:16–22.
James MJ, Cleland LG. Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Sem Arthritis Rheum 1997;27:85–97.
Wilhelmi G. Potential influence of nutrition with supplements on healthy and arthritic joints. II. Nutritional quantity, supplements, contamination]. Z Rheumatol 1993; 52:191–200.
Warady BD, Lindsley CB, Robinson FG, Lukert BP. Effects of nutritional supplementation on bone mineral status of children with rheumatic diseases receiving corticosteroid therapy. J Rheumatol 1994; 21:530–535.
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© 2002 Kluwer Academic/Plenum Publishers
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Sullivan, B.D. et al. (2002). Correlations between Nutrient Intake and the Polar Lipid Profiles of Meibomian Gland Secretions in Women with Sjögren’s Syndrome. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_62
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_62
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