Abstract
The rheological properties of mucus secretions from various sites in the body are related to their particular physiological function. Although in normal circumstances the body produces secretions with optimal rheological properties to fulfil such functions, during disease the mucus produced may be too thick or too thin and in both cases may behave sub-optimally. In such situations it becomes attractive to administer chemical agents or drugs, either locally or systemically, which modify the rheological properties in an attempt to correct function. Furthermore, in certain cases it may be desirable to artificially manipulate the consistency of the mucus in order to produce a specific effect.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brown, D.T., 1980, Ph.D. Thesis, University of Nottingham.
Chodosh, S., 1980, Acetylcysteine in chronic bronchitis, Eur. J. Respir. Dis., 61(S111): 90.
Crowther, R.S. and Marriott, C., 1979, Cation induced changes in the biophysical properties of mucins, J. Pharm. Pharmac., 31: 89P.
Davis, S.S. and Deverell, L.C., 1977, Rheological factors in mucociliary clearance, Mod. Probl. Paediat., 19: 207.
Forstner, J.F. and Forstner, G.G., 1975, Calcium binding to intestinal goblet cell mucin, Biochim. Biophys. Acta, 386: 283.
Gelman, R.A. and Meyer, F.A., 1979, Mucociliary transference rate and mucus viscoelasticity dependence on dynamic storage and loss modulus, Am. Rev. resp. Dis., 120: 553.
Hirsch, S.R., Zastrow, J.E. and Kory, R.C., 1969, Sputum liquefying agents: a comparative in vitro evaluation, J. Lab. Clin. Med., 74: 346.
Khan, M.A., Wolf, D.P. and Litt, M., 1976, Effect of mucolytic agents on the rheological properties of tracheal mucus, Biochim. Biophys. Acta, 444: 369.
King, M., Engel, L.A. and Macklem, P.T., 1979, Effect of pentobarbital anesthesia on rheology and transport of canine tracheal mucus, J. Appl. Physiol., 46: 504.
Kosasky, H.J., Kopito, E.L., Somers, H.S. and Shwachman, H., 1973, Changes in water and electrolytes in human cervical mucus during treatment with chlormadinone acetate, Fertil. Steril., 24: 507.
Lieberman, J., 1968, Measurement of sputum viscosity in a coneplate viscometer, Amer. Rev. resp. Dis., 97: 662.
Lightowler, J.E. and Lightowler, N.M., 1971, Comparative mucolytic studies on dithiothreitol, N-acetylcysteine and L-cysteine on human respiratory mucus in vitro and their effects on the role of flow of mucus in the exposed trachea of the rat on topical application, Arch. int. Pharmacodyn., 189: 53.
Martin, R., Litt, M. and Marriott, C., 1980, The effect of mucolytic agents on the rheologic and transport properties of canine tracheal mucus, Amer. Rev. resp. Dis., 121: 495.
Martin, G., Marriott, C. and Kellaway, I.W., 1981, The interaction of progesterone with mucus glycoproteins, Pharm. Acta Helv., 56: 5.
Marriott, C., Beeson, M.F. and Brown, D.T., 1981a, Biopolymer induced changes in mucus viscoelasticity, this conference.
Marriott, C., Brown, D.T. and Beeson, M.F., 1981b, Evaluation of mucolytic activity using a purified mucus glycoprotein gel, this conference.
Marriott, C. and Kellaway, I.W., 1975, The effect of tetracyclines on the viscoelastic properties of bronchial mucus, Biorheology, 12: 391.
Marriott, C. and Richards, J.H., 1974, The effects of storage and of potassium iodide, urea, N-acetylcysteine and Triton X-100 on the viscosity of bronchial mucus, Brit. J. Dis. Chest, 68: 171.
Marriott, C., Shih, C.K. and Litt, M., 1979, Changes in the gel properties of tracheal mucus induced by divalent cations, Biorheology, 16: 331.
McNiff, E., Clemente, E. and Fung, H.L., 1975, In vitro comparison of the mucolytic activity of sodium metabisulfite, N-acetylcysteine and dithiothreitol, Drug Dev.Comm., 1: 507.
Shih, C.K., Litt, M., Khan, M.A. and Wolf, D.P., 1977, Effect of non-dialysable solids concentration and viscoelasticity on ciliary transport of tracheal mucus., Am. Rev. resp. Dis., 115: 989.
Tabachnik, N.F., Peterson, C.M. and Cerami, A., 1980, Studies on the reduction of sputum viscosity in cystic fibrosis using an orally absorbed protected thiol, J. Pharmacol. Exp. Ther., 214: 246.
Verstraeten, J -M., 1980, Mucolytic treatment in chronic airways obstruction. Double-blind clinical trial with acetylcysteine, bromhexine and placebo., Eur. J. Respir. Dis., 61(S111): 77.
Ziment, I., 1978, Respiratory Pharmacology and Therapeutics, W.B. Saunders, Philadelphia.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Marriott, C. (1982). Modification of the Rheological Properties of Mucus by Drugs. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9254-9_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9256-3
Online ISBN: 978-1-4615-9254-9
eBook Packages: Springer Book Archive