Abstract
The morphologic changes of age which concern the neuropathologist must be not only those he can correlate with clinical signs and symptoms, but also those he can relate to fundamental biology. It is the purpose of this paper to provide as much of this structural correlation as is currently possible in regard to Alzheimer’s disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams, R.D., and Sidman, R.L. 1968. Introduction to Neuropathology. New York: The Blakiston Division, McGraw-Hill Book Company, p. 511.
Bensch, K.G.; Marantz, R.; Wisniewski, H. and Shelanski, M. 1969. Induction in vitro of microtubular crystals by vinca alkaloids. Science 165:495.
Braunmiihl, A.v. 1957. Alterserkrankungen des Zentralnervensystems. Senile Involution. Senile Demenz. Alzheimersche Krankheit. In Handbuch der Speziellen Pathologischen Anatomie und Histologie, XIII. Part 1. A. Erkrankungen des zentralen Nervensystems 1:337. O. Lubarsch, F. Henke, and R. Rössle (eds.). Berlin: Springer Verlag.
Feldman, R.G.; Chandler, K.A.; Levy, L.L.; and Glaser, G.H. 1963. Familial Alzheimer’s disease. Neurology 13:811.
Glenner, G.G.; Terry, W.; Harada, M.; Isersky, C.; and Page, D. 1971. Amyloid fibril proteins: Proof of homology with immunoglobulin light chains by sequence analyses. Science 172:1150.
Gonatas, N.K., and Robbins, E. 1964. The homology of spindle tubules and neuro-tubules in the chick embryo retina. Protoplasma 59:25.
Gonatas, N.K.; Terry, R.D.; and Weiss, M. 1965. Electron microscopic study in two cases of Jakob-Creutzfeldt disease. J. Neuropath. Exp. Neurol. 24:575.
Hallgren, B., and Sourander, P. 1960. The non-haemin iron in the cerebral cortex in Alzheimer’s disease. J. Neurochem. 5:307.
Hirano, A. 1970. Neurofibrillary changes in conditions related to Alzheimer’s disease. In Ciba Foundation Symposium on Alzheimer’s Disease and Related Conditions. G.E.W. Wolstenholme and M. O’Connor (eds.). London: J. & A. Churchill, p. 185.
Hirano, A.; Dembitzer, H.M.; Kurland, L.T.; and Zimmerman, H.M. 1968. The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and “rod-like” structures as seen in Guam amyotrophic lateral sclerosis and Parkinsonism-Dementia complex. J. Neuropath. Exp. Neurol. 27:167.
Karlsson, J.-O.; Hansson, H.-A.; and Sjöstrand, J. 1971. Effect of colchicine on axonal transport and morphology of retinal ganglion cells. Z. Zellforsch. 115:265.
Kidd, M. 1963. Paired helical filaments in electron microscopy of Alzheimer’s disease. Nature 197:192.
Klatzo, I.; Wisniewski, H.; and Streicher, E. 1965. Experimental production of neurofibrillary degeneration. I. Light microscopic observations. J. Neuropath. Exp. Neurol. 24:187.
Krücke, W. 1961. Chronic sclerosing “leucoencephalitis and polyneuritis with intranuclear inclusion bodies”. In Encephalitides. Proceedings of a Symposium on the Neuropathology, Electroencephalography and Biochemistry of Encephalitides, Antwerp 1959. L. Van Bogaert, J. Radermecker, H. Hozay, and A. Lowenthal (eds.). Amsterdam: Elsevier Publishing Company, p. 560.
Marantz, R.; Ventilla, M.; and Shelanski, M. 1969. Vinblastine-induced precipitation of microtubule protein. Science 165:498.
Matsuyama, H.; Namiki, H.; and Watanabe, I. 1966. Senile changes in the brain in the Japanese. Incidence of Alzheimer’s neurofibrillary change and senile plaques. In Proceedings of the 5th International Congress of Neuropathology. F. Luthy and A. Bischoff (eds.). Excerpta Medica Series No. 100, p. 979.
Olson, M.I., and Shaw, C.-M. 1969. Presenile dementia and Alzheimer’s disease in mongolism. Brain 92:147.
Peterson, E., and Murray, M. 1966. Serial observations in tissue cultures on neurotoxic effects of colchicine. Anat. Rec. 154:401 (abstr.).
Porter, K.R. 1966. Cytoplasmic microtubules and their functions. In Ciba Foundation Symposium on Principles of Biomolecular Organization. G.E.W. Wolstenholme and M. O’Connor (eds.). Boston: Little, Brown, p. 308.
Roth, M.; Tomlinson, B.E.; and Blessed, G. 1966. Correlation between scores for dementia and counts of “senile plaques” in cerebral grey matter of elderly subjects. Nature 209:109.
Schochet, S.S., Jr.; Lampert, P.W.; and Earle, K.M. 1968. Neuronal changes induced by intrathecal vincristine sulfate. J. Neuropath. Exp. Neurol. 27:645.
Shelanski, M.L.; Liwnicz, B.H.; and Slusarek, W. 1971. Biochemical studies on Guam Parkinsonism Dementia. Trans. Amer. Assoc. Neuropath. San Juan, P.R., June 1971. P. 36.
Shelanski, M.L., and Wisniewski, H. 1969. Neurofibrillary degeneration induced by vincristine therapy. Arch. Neurol 20:199.
Suzuki, K., and Terry, R.D. 1967. Fine structural localization of acid phosphatase in senile plaques in Alzheimer’s presenile dementia. Acta Neuropath. 8:276.
Terry, R.D. 1963. The fine structure of neurofibrillary tangles in Alzheimer’s disease. J. Neuropath. Exp. Neurol. 22:629.
Terry, R.D. 1971. Presidential address. Neuronal fibrous protein in human pathology. J. Neuropath. Exp. Neurol. 30:8.
Terry, R.D., Gonatas, N.K.; and Weiss, M. 1964. Ultrastructural studies in Alzheimer’s presenile dementia. Amer. J. Path. 44:269.
Terry, R.D., and Peña, C. 1965. Experimental production of neurofibrillary degeneration. 2. Electron microscopy, phosphatase histochemistry and electron probe analysis. J. Neuropath. Exp. Neurol. 24:200.
Terry, R.D., and Wisniewski, H.M. 1970. The ultrastructure of the neurofibrillary tangle and the senile plaque. In Ciba Foundation Symposium on Alzheimer’s Disease and Related Conditions. G.E.W. Wolstenholme and M. O’Connor (eds.). London: J. & A. Churchill, p. 145.
Wisniewski, H.M.; Coblentz, J.M.; and Terry, R.D. 1971. Pick’s disease. A clinical and ultrastructural study. Arch Neurol (in press).
Wisniewski, H.; Johnson, A.B.; Raine, C.S.; Kay, W.J.; and Terry, R.D. 1970. Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study. Lab. Invest. 23:287.
Wisniewski, H.; Shelanski, M.L.; and Terry, R.D. 1968. Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells. J. Cell Biol. 38:224.
Wisniewski, H.; and Terry, R.D. 1970. An experimental approach to the morphogenesis of neurofibrillary degeneration and the argyrophilic plaque. In Ciba Foundation Symposium on Alzheimer’s Disease and Related Conditions. G.E.W. Wolstenholme and M.O’Connor (eds.). London: J. & A. Churchill, p. 223.
Wisniewski, H.M.; and Terry, R.D. 1972. Reexamination of the pathogenesis of the senile plaque. In Progress in Neuropathology, vol. 2. H.M. Zimmerman (ed.). New York: Grune & Stratton (in press).
Wisniewski, H.; Terry, R.D.; and Hirano, A. 1970. Neurofibrillary pathology. J. Neuropath. Exp. Neurol. 29:163.
Zucker-Franklin, D., and Franklin, E.C. 1970. Intracellular localization of human amyloid by fluorescence and electron microscopy. Amer. J. Path. 59:23.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1972 Plenum Press, New York
About this chapter
Cite this chapter
Terry, R.D., Wiśniewski, H.M. (1972). Ultrastructure of Senile Dementia and of Experimental Analogs. In: Gaitz, C.M. (eds) Aging and the Brain. Advances in Behavioral Biology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8503-5_7
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8503-5_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8505-9
Online ISBN: 978-1-4684-8503-5
eBook Packages: Springer Book Archive